hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12192.1
Complex Portal: CPX-24410
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | 5 | UniProt NCBI |
| PON3 | Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) | 5 | UniProt NCBI |
| GRIN1 | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) | 5 | UniProt NCBI |
| HGSNAT | Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) | 5 | UniProt NCBI |
| TMEM158 | Transmembrane protein 158 (40 kDa BINP-binding protein) (p40BBP) (Ras-induced senescence protein 1) | 3 | UniProt NCBI |
| GABRQ | Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta) | 5 | UniProt NCBI |
| FUT10 | Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10) | 5 | UniProt NCBI |
| SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) | 5 | UniProt NCBI |
| ASIC4 | Acid-sensing ion channel 4 (ASIC4) (Amiloride-sensitive cation channel 4) (Amiloride-sensitive cation channel 4, pituitary) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05033 | 0.0046708432359 | 0.222222222222 | GABRQ GRIN1 | Nicotine addiction |
| HP:0025097 | 0.0064253619375 | 0.222222222222 | SLC6A1 GRIN1 | Eyelid myoclonus |
| WP:WP4159 | 0.00842967875969 | 0.222222222222 | GABRQ SLC6A1 | GABA receptor signaling |
| KEGG:04727 | 0.0369068821541 | 0.222222222222 | GABRQ SLC6A1 | GABAergic synapse |
| WP:WP5420 | 0.0398484415758 | 0.333333333333 | GABRQ GRIN1 SLC6A1 | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-112315 | 0.0494149485675 | 0.333333333333 | GABRQ GRIN1 SLC6A1 | Transmission across Chemical Synapses |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ASIC4 | FUT10 | 0.999 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ERN1 | ASIC4 | 0.999 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ASIC4 | PON3 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GABRQ | ASIC4 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GRIN1 | ASIC4 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TMEM158 | ASIC4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HGSNAT | ASIC4 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TMEM158 | FUT10 | 0.904 | bioplex3_WMM WMM_only | ||
| TMEM158 | GRIN1 | 0.902 | bioplex3_WMM WMM_only | ||
| GABRQ | GRIN1 | 0.869 | bioplex3_WMM WMM_only | ||
| ERN1 | SLC6A1 | 0.818 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GRIN1 | FUT10 | 0.768 | bioplex3_WMM WMM_only | ||
| GRIN1 | PON3 | 0.768 | bioplex3_WMM WMM_only | ||
| TMEM158 | PON3 | 0.703 | bioplex3_WMM WMM_only | ||
| TMEM158 | GABRQ | 0.698 | bioplex3_WMM WMM_only | ||
| ERN1 | GRIN1 | 0.675 | bioplex3_WMM WMM_only | ||
| GABRQ | FUT10 | 0.633 | bioplex3_WMM WMM_only | ||
| GABRQ | PON3 | 0.633 | bioplex3_WMM WMM_only | ||
| ERN1 | TMEM158 | 0.427 | bioplex3_WMM WMM_only | ||
| PON3 | FUT10 | 0.405 | bioplex3_WMM WMM_only | ||
| ERN1 | FUT10 | 0.364 | bioplex3_WMM WMM_only | ||
| ERN1 | PON3 | 0.356 | bioplex3_WMM WMM_only | ||
| ERN1 | GABRQ | 0.356 | bioplex3_WMM WMM_only | ||
| TMEM158 | HGSNAT | 0.214 | bioplex3_WMM WMM_only | ||
| GRIN1 | HGSNAT | 0.108 | bioplex3_WMM WMM_only | ||
| GABRQ | HGSNAT | 0.108 | bioplex3_WMM WMM_only | ||
| HGSNAT | PON3 | 0.055 | bioplex3_WMM WMM_only | ||
| HGSNAT | FUT10 | 0.055 | bioplex3_WMM WMM_only | ||
| ERN1 | HGSNAT | 0.042 | 0.062 | bioplex3_WMM WMM_only |
Related Complexes