hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12199.1
Complex Portal: CPX-14823
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EMC6 | ER membrane protein complex subunit 6 (Transmembrane protein 93) | 5 | UniProt NCBI |
| EMC4 | ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85) | 5 | UniProt NCBI |
| EMC7 | Endoplasmic reticulum membrane protein complex subunit 7 (ER membrane protein complex subunit 7) | 5 | UniProt NCBI |
| EMC9 | ER membrane protein complex subunit 9 (Protein FAM158A) | 4 | UniProt NCBI |
| EMC8 | ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B) | 5 | UniProt NCBI |
| EMC2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) | 5 | UniProt NCBI |
| EMC10 | ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1) | 5 | UniProt NCBI |
| EMC3 | ER membrane protein complex subunit 3 (Transmembrane protein 111) | 5 | UniProt NCBI |
| NADSYN1 | Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0072546 | 3.92947304954e-22 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | EMC complex |
| GO:0045050 | 1.44071909585e-21 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | protein insertion into ER membrane by stop-transfer membrane-anchor sequence |
| GO:0032977 | 1.12341890771e-19 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | membrane insertase activity |
| GO:0071816 | 2.12188429723e-19 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | tail-anchored membrane protein insertion into ER membrane |
| GO:0045048 | 3.74363668751e-17 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | protein insertion into ER membrane |
| GO:0140597 | 5.10464806656e-17 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | protein carrier chaperone |
| GO:0051205 | 4.2630551964e-16 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | protein insertion into membrane |
| GO:0007029 | 2.26854817883e-13 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | endoplasmic reticulum organization |
| GO:0140104 | 2.52045503378e-13 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | molecular carrier activity |
| GO:0140534 | 2.42061469838e-12 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | endoplasmic reticulum protein-containing complex |
| GO:0090150 | 6.80123682923e-10 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | establishment of protein localization to membrane |
| GO:0010256 | 2.63044979846e-07 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | endomembrane system organization |
| GO:0072657 | 3.15498215751e-07 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | protein localization to membrane |
| GO:0051668 | 1.25705502396e-06 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | localization within membrane |
| GO:0061024 | 2.06750902349e-06 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | membrane organization |
| GO:0005789 | 1.18896696569e-05 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | endoplasmic reticulum membrane |
| GO:0098827 | 1.34610089158e-05 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | endoplasmic reticulum subcompartment |
| GO:0042175 | 1.43922631988e-05 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | nuclear outer membrane-endoplasmic reticulum membrane network |
| GO:0033365 | 1.67870755226e-05 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | protein localization to organelle |
| GO:0098796 | 0.000104514348172 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | membrane protein complex |
| GO:0031984 | 0.000120878386511 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | organelle subcompartment |
| GO:0045184 | 0.000201062761255 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | establishment of protein localization |
| GO:0005783 | 0.00258810849346 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | endoplasmic reticulum |
| GO:0008104 | 0.0106312413975 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | protein localization |
| GO:0070727 | 0.0108364404347 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | cellular macromolecule localization |
| GO:0033036 | 0.0387294083726 | 0.888888888889 | EMC4 EMC2 EMC3 EMC7 EMC10 EMC9 EMC8 EMC6 | macromolecule localization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EMC7 | EMC3 | 1.0 | 0.956 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| EMC4 | EMC3 | 1.0 | 0.8 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| EMC10 | EMC3 | 1.0 | 0.838 |
structurally_consistent (Q8N766)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC6 | EMC2 | 1.0 | 0.43 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC9 | EMC10 | 1.0 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EMC2 | EMC10 | 1.0 | 0.73 |
structurally_consistent (Q8N766)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC8 | EMC2 | 1.0 | 0.894 |
structurally_consistent (Q5UCC4)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC9 | EMC2 | 1.0 | 0.214 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC2 | EMC3 | 1.0 | 0.936 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC7 | EMC8 | 1.0 | 0.77 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EMC7 | EMC9 | 1.0 | 0.328 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EMC4 | EMC9 | 1.0 | 0.222 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EMC4 | EMC7 | 1.0 | 0.532 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EMC8 | EMC3 | 1.0 | 0.706 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| EMC7 | EMC10 | 1.0 | 0.888 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EMC4 | EMC2 | 1.0 | 0.668 |
structurally_consistent (Q8N766)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC4 | EMC8 | 1.0 | 0.324 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EMC6 | EMC9 | 1.0 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EMC6 | EMC10 | 1.0 | 0.206 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| EMC9 | EMC3 | 1.0 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EMC7 | EMC2 | 1.0 | 0.854 |
structurally_consistent (Q8N766)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC6 | EMC4 | 0.999 | 0.172 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| EMC6 | EMC7 | 0.999 | 0.32 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| EMC6 | EMC8 | 0.999 | 0.338 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| EMC6 | EMC3 | 0.999 | 0.364 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| EMC8 | EMC10 | 0.999 | 0.546 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EMC4 | EMC10 | 0.998 | 0.56 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EMC6 | NADSYN1 | 0.996 | 0.03 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EMC9 | EMC8 | 0.971 | 0.288 |
mutually_exclusive (Q15006)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EMC2 | NADSYN1 | 0.971 | 0.04 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EMC3 | NADSYN1 | 0.745 | 0.03 | bioplex_WMM bioplex3_WMM WMM_only | |
| EMC4 | NADSYN1 | 0.725 | 0.014 | bioplex_WMM bioplex3_WMM WMM_only | |
| EMC8 | NADSYN1 | 0.716 | 0.016 |
structurally_consistent (Q15006)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EMC7 | NADSYN1 | 0.685 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only | |
| EMC9 | NADSYN1 | 0.6 | 0.03 |
structurally_consistent (Q15006)
|
bioplex3_WMM WMM_only |
| EMC10 | NADSYN1 | 0.58 | 0.012 |
structurally_consistent (Q15006)
|
bioplex3_WMM WMM_only |
Related Complexes