hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12203.1
Complex Portal: CPX-25179
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RFESD | Rieske domain-containing protein | 2 | UniProt NCBI |
| PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) | 5 | UniProt NCBI |
| PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) | 5 | UniProt NCBI |
| DCLRE1C | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | 5 | UniProt NCBI |
| PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | 5 | UniProt NCBI |
| PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | 5 | UniProt NCBI |
| PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | 5 | UniProt NCBI |
| JAKMIP1 | Janus kinase and microtubule-interacting protein 1 (GABA-B receptor-binding protein) (Multiple alpha-helices and RNA-linker protein 1) (Marlin-1) | 5 | UniProt NCBI |
| PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | 5 | UniProt NCBI |
| PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4905 | 7.11894614088e-17 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | 1q21 1 copy number variation syndrome |
| WP:WP3965 | 2.74385173496e-16 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Lipid metabolism pathway |
| REAC:R-HSA-2151209 | 3.14903714729e-16 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG3 PRKAG2 PRKAG1 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| REAC:R-HSA-9613354 | 3.14903714729e-16 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG3 PRKAG2 PRKAG1 | Lipophagy |
| KEGG:04710 | 4.34113989491e-16 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Circadian rhythm |
| REAC:R-HSA-9619483 | 4.92166885632e-16 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Activation of AMPK downstream of NMDARs |
| WP:WP4923 | 4.93715625956e-16 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Autophagy |
| GO:0031588 | 1.36627528034e-15 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | nucleotide-activated protein kinase complex |
| REAC:R-HSA-380972 | 1.59686209997e-15 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Energy dependent regulation of mTOR by LKB1-AMPK |
| WP:WP1471 | 2.24074712477e-15 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Target of rapamycin signaling |
| WP:WP4539 | 1.59327814977e-14 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Synaptic signaling pathways associated with autism spectrum disorder |
| WP:WP1541 | 1.59327814977e-14 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Energy metabolism |
| REAC:R-HSA-165159 | 2.29520475049e-14 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | MTOR signalling |
| KEGG:04213 | 3.76020651516e-14 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Longevity regulating pathway - multiple species |
| KEGG:04920 | 1.1728025348e-13 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Adipocytokine signaling pathway |
| WP:WP1403 | 1.80836253408e-13 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | AMP activated protein kinase signaling |
| WP:WP1982 | 4.01332111768e-13 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Sterol regulatory element binding proteins SREBP signaling |
| KEGG:05410 | 4.62334972164e-13 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Hypertrophic cardiomyopathy |
| KEGG:04211 | 7.34697990974e-13 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Longevity regulating pathway |
| REAC:R-HSA-438064 | 9.84911655933e-13 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Post NMDA receptor activation events |
| WP:WP4963 | 1.43613209653e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | p53 transcriptional gene network |
| WP:WP4540 | 1.56988772271e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Hippo signaling regulation pathways |
| KEGG:04922 | 1.84733731944e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Glucagon signaling pathway |
| KEGG:04931 | 2.91410162761e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Insulin resistance |
| REAC:R-HSA-5628897 | 2.93916579209e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-442755 | 3.22042237946e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Activation of NMDA receptors and postsynaptic events |
| WP:WP4321 | 3.33688522111e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Thermogenesis |
| REAC:R-HSA-6804756 | 6.97372726225e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Regulation of TP53 Activity through Phosphorylation |
| KEGG:04371 | 7.13736507362e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Apelin signaling pathway |
| KEGG:04152 | 8.11301287986e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | AMPK signaling pathway |
| KEGG:04068 | 8.11301287986e-12 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | FoxO signaling pathway |
| KEGG:04921 | 1.10654306562e-11 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Oxytocin signaling pathway |
| KEGG:04936 | 1.57817124683e-11 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Alcoholic liver disease |
| WP:WP3915 | 1.68931346843e-11 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Angiopoietin like protein 8 regulatory pathway |
| KEGG:04910 | 1.76949177848e-11 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Insulin signaling pathway |
| KEGG:04530 | 3.56727249483e-11 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Tight junction |
| KEGG:04932 | 3.56727249483e-11 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Non-alcoholic fatty liver disease |
| WP:WP4396 | 6.28825938835e-11 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Nonalcoholic fatty liver disease |
| REAC:R-HSA-1632852 | 8.48843157502e-11 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Macroautophagy |
| REAC:R-HSA-9612973 | 1.89473550222e-10 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Autophagy |
| REAC:R-HSA-5633007 | 3.23503347085e-10 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Regulation of TP53 Activity |
| REAC:R-HSA-112314 | 4.26034978912e-10 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-1445148 | 4.43107346479e-10 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG3 PRKAG2 PRKAG1 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| KEGG:04714 | 5.62344564439e-10 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Thermogenesis |
| REAC:R-HSA-9663891 | 7.43241205385e-10 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG3 PRKAG2 PRKAG1 | Selective autophagy |
| REAC:R-HSA-1592230 | 1.7309032713e-09 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG3 PRKAG2 PRKAG1 | Mitochondrial biogenesis |
| REAC:R-HSA-112315 | 2.51702012185e-09 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Transmission across Chemical Synapses |
| GO:0004679 | 5.52565251192e-09 | 0.4 | PRKAG3 PRKAB2 PRKAA2 PRKAA1 | AMP-activated protein kinase activity |
| CORUM:6154 | 1.68385473419e-08 | 0.3 | PRKAB2 PRKAG1 PRKAA1 | PRKAA1-PRKAB2-PRKAG1 complex |
| CORUM:6155 | 1.68385473419e-08 | 0.3 | PRKAB2 PRKAG1 PRKAA2 | PRKAA2-PRKAB2-PRKAG1 complex |
| CORUM:6153 | 1.68385473419e-08 | 0.3 | PRKAB2 PRKAA2 PRKAG3 | PRKAA2-PRKAB2-PRKAG3 complex |
| REAC:R-HSA-112316 | 3.75830877198e-08 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Neuronal System |
| GO:1902911 | 4.33624008845e-08 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | protein kinase complex |
| WP:WP5087 | 7.23881444573e-08 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Pleural mesothelioma |
| REAC:R-HSA-3700989 | 9.08633088804e-08 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Transcriptional Regulation by TP53 |
| GO:0031669 | 1.00801413132e-07 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | cellular response to nutrient levels |
| GO:0031668 | 1.48319732706e-07 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | cellular response to extracellular stimulus |
| GO:0071496 | 5.39438611834e-07 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | cellular response to external stimulus |
| GO:0031667 | 8.90392170914e-07 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | response to nutrient levels |
| GO:0009991 | 1.25813989658e-06 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | response to extracellular stimulus |
| REAC:R-HSA-1852241 | 2.00168126322e-06 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG3 PRKAG2 PRKAG1 | Organelle biogenesis and maintenance |
| WP:WP3934 | 2.71781665291e-06 | 0.3 | PRKAB1 PRKAG1 PRKAA1 | Leptin and adiponectin |
| REAC:R-HSA-163680 | 3.11481667251e-06 | 0.3 | PRKAB2 PRKAA2 PRKAG2 | AMPK inhibits chREBP transcriptional activation activity |
| GO:0061695 | 4.54026119978e-06 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | transferase complex, transferring phosphorus-containing groups |
| CORUM:6888 | 6.10504685098e-06 | 0.3 | PRKAB1 PRKAG1 PRKAA1 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| REAC:R-HSA-200425 | 1.58792502117e-05 | 0.3 | PRKAB2 PRKAA2 PRKAG2 | Carnitine metabolism |
| WP:WP4206 | 2.57266083477e-05 | 0.3 | PRKAB1 PRKAG1 PRKAA1 | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| REAC:R-HSA-199991 | 0.000156920308014 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG3 PRKAG2 PRKAG1 | Membrane Trafficking |
| REAC:R-HSA-212436 | 0.000196550905286 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Generic Transcription Pathway |
| GO:0140535 | 0.000198990526838 | 0.8 | PRKAB1 PRKAB2 PRKAA2 PRKAG1 DCLRE1C PRKAG3 PRKAG2 PRKAA1 | intracellular protein-containing complex |
| REAC:R-HSA-5653656 | 0.00021603253711 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG3 PRKAG2 PRKAG1 | Vesicle-mediated transport |
| GO:0030811 | 0.000322081911533 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of nucleotide catabolic process |
| GO:0033121 | 0.000322081911533 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of purine nucleotide catabolic process |
| GO:0006110 | 0.000322081911533 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of glycolytic process |
| REAC:R-HSA-73857 | 0.000415350299084 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | RNA Polymerase II Transcription |
| GO:0043470 | 0.000610805882605 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of carbohydrate catabolic process |
| REAC:R-HSA-74160 | 0.000973001799799 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Gene expression (Transcription) |
| GO:1903578 | 0.00105973484827 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of ATP metabolic process |
| GO:0016208 | 0.0018977127037 | 0.3 | PRKAG2 PRKAG1 PRKAG3 | AMP binding |
| GO:1900542 | 0.00246977648377 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of purine nucleotide metabolic process |
| GO:0006140 | 0.0026453176903 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of nucleotide metabolic process |
| GO:0046032 | 0.00366675599097 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | ADP catabolic process |
| GO:0006096 | 0.00366675599097 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | glycolytic process |
| GO:0046031 | 0.00390203518198 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | ADP metabolic process |
| GO:0009137 | 0.00414841649454 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | purine nucleoside diphosphate catabolic process |
| GO:0009181 | 0.00414841649454 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | purine ribonucleoside diphosphate catabolic process |
| GO:0009179 | 0.00440624055344 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | purine ribonucleoside diphosphate metabolic process |
| GO:0019364 | 0.00440624055344 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | pyridine nucleotide catabolic process |
| GO:0009135 | 0.00467585293512 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | purine nucleoside diphosphate metabolic process |
| GO:0009191 | 0.00495760415907 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | ribonucleoside diphosphate catabolic process |
| GO:0072526 | 0.0052518496793 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | pyridine-containing compound catabolic process |
| GO:0009134 | 0.00555894987576 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | nucleoside diphosphate catabolic process |
| GO:1990234 | 0.00609373273501 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | transferase complex |
| REAC:R-HSA-163685 | 0.00655835959712 | 0.3 | PRKAB2 PRKAA2 PRKAG2 | Integration of energy metabolism |
| GO:0004672 | 0.00682206377487 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG1 PRKAA1 PRKAG3 | protein kinase activity |
| GO:0009185 | 0.00692327695124 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | ribonucleoside diphosphate metabolic process |
| WP:WP1981 | 0.00704825789595 | 0.2 | PRKAA2 PRKAA1 | Thyroxine thyroid hormone production |
| GO:0009132 | 0.00852338417127 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | nucleoside diphosphate metabolic process |
| WP:WP5381 | 0.0096733368737 | 0.3 | PRKAG2 PRKAA1 PRKAB1 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| GO:0006090 | 0.0125338195416 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | pyruvate metabolic process |
| GO:0009154 | 0.0149986773182 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | purine ribonucleotide catabolic process |
| GO:0009261 | 0.0163585481162 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | ribonucleotide catabolic process |
| GO:0043467 | 0.0185681816185 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of generation of precursor metabolites and energy |
| REAC:R-HSA-162582 | 0.0190896791054 | 0.7 | PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG3 PRKAG2 PRKAG1 | Signal Transduction |
| GO:0006195 | 0.0193519317401 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | purine nucleotide catabolic process |
| GO:1903943 | 0.0210690324038 | 0.2 | PRKAA2 PRKAA1 | regulation of hepatocyte apoptotic process |
| GO:0140823 | 0.0210690324038 | 0.2 | PRKAA2 PRKAA1 | histone H2BS36 kinase activity |
| GO:1903944 | 0.0210690324038 | 0.2 | PRKAA2 PRKAA1 | negative regulation of hepatocyte apoptotic process |
| GO:0140998 | 0.0210690324038 | 0.2 | PRKAA2 PRKAA1 | histone H2B kinase activity |
| GO:0016773 | 0.0216782921932 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG1 PRKAA1 PRKAG3 | phosphotransferase activity, alcohol group as acceptor |
| GO:0072523 | 0.0227360626478 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | purine-containing compound catabolic process |
| GO:0016052 | 0.0245846488989 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | carbohydrate catabolic process |
| GO:1902494 | 0.0260248958425 | 0.8 | PRKAB1 PRKAB2 PRKAA2 PRKAG1 DCLRE1C PRKAG3 PRKAG2 PRKAA1 | catalytic complex |
| REAC:R-HSA-8978868 | 0.0268899937774 | 0.3 | PRKAB2 PRKAA2 PRKAG2 | Fatty acid metabolism |
| GO:0006109 | 0.0319473224786 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | regulation of carbohydrate metabolic process |
| GO:0016301 | 0.0328176777322 | 0.6 | PRKAB1 PRKAB2 PRKAA2 PRKAG1 PRKAA1 PRKAG3 | kinase activity |
| WP:WP3878 | 0.0335282776025 | 0.2 | DCLRE1C PRKAA1 | ATM signaling in development and disease |
| GO:0009166 | 0.0368293644996 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | nucleotide catabolic process |
| GO:0019362 | 0.0422468474482 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | pyridine nucleotide metabolic process |
| GO:0046496 | 0.0422468474482 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | nicotinamide nucleotide metabolic process |
| GO:1901292 | 0.0436892060701 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | nucleoside phosphate catabolic process |
| GO:0072524 | 0.0482368973245 | 0.4 | PRKAG2 PRKAG1 PRKAA1 PRKAA2 | pyridine-containing compound metabolic process |
| CORUM:771 | 0.0499436884912 | 0.1 | PRKAA1 | NDPKA-AMPKalpha1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PRKAB2 | PRKAA1 | 1.0 | 0.352 |
mutually_exclusive (Q9Y478)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction |
| PRKAB1 | PRKAA1 | 1.0 | 0.266 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| PRKAA2 | PRKAB1 | 1.0 | 0.104 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| PRKAG1 | PRKAB1 | 1.0 | 0.414 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| PRKAB2 | PRKAA2 | 1.0 | 0.254 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRKAG1 | PRKAA1 | 1.0 | 0.568 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| PRKAG2 | PRKAB1 | 1.0 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| PRKAG1 | PRKAB2 | 1.0 | 0.384 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRKAG2 | PRKAA2 | 1.0 | 0.146 |
mutually_exclusive (Q9Y478)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PRKAB2 | PRKAG2 | 1.0 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRKAG2 | PRKAA1 | 1.0 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| PRKAB2 | PRKAG3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PRKAB1 | PRKAG3 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRKAA2 | PRKAG3 | 0.999 |
mutually_exclusive (Q9Y478)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRKAG1 | PRKAA2 | 0.999 | 0.146 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| PRKAB2 | PRKAB1 | 0.998 | 0.274 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PRKAA1 | PRKAG3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PRKAA2 | PRKAA1 | 0.989 | 0.136 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| JAKMIP1 | DCLRE1C | 0.958 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PRKAG1 | PRKAG2 | 0.952 | 0.12 |
mutually_exclusive (Q9Y478)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PRKAA2 | DCLRE1C | 0.952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PRKAA1 | DCLRE1C | 0.927 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PRKAG1 | DCLRE1C | 0.921 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RFESD | PRKAG1 | 0.84 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RFESD | PRKAA1 | 0.832 |
mutually_exclusive (P54619)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PRKAB1 | DCLRE1C | 0.755 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PRKAB2 | DCLRE1C | 0.362 | bioplex () bioplex_WMM | ||
| PRKAG2 | DCLRE1C | 0.319 | bioplex () bioplex_WMM | ||
| PRKAG1 | JAKMIP1 | 0.102 | bioplex3_WMM WMM_only | ||
| PRKAA2 | JAKMIP1 | 0.078 | bioplex3_WMM WMM_only | ||
| PRKAB1 | JAKMIP1 | 0.078 | bioplex3_WMM WMM_only | ||
| PRKAA1 | JAKMIP1 | 0.076 | bioplex3_WMM WMM_only | ||
| RFESD | PRKAB1 | 0.041 | bioplex3_HEK293 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RFESD | huMAP3_00171.1 huMAP3_12203.1 huMAP3_15104.1 |
| PRKAG1 | huMAP3_01652.1 huMAP3_12203.1 |
| PRKAB2 | huMAP3_01652.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_12203.1 |
| DCLRE1C | huMAP3_04659.1 huMAP3_05190.1 huMAP3_10618.1 huMAP3_12203.1 huMAP3_14755.1 |
| PRKAA2 | huMAP3_01652.1 huMAP3_12203.1 |
| PRKAG2 | huMAP3_01652.1 huMAP3_12203.1 |
| PRKAA1 | huMAP3_01652.1 huMAP3_12203.1 |
| JAKMIP1 | huMAP3_04380.1 huMAP3_05190.1 huMAP3_10618.1 huMAP3_12203.1 huMAP3_14755.1 |
| PRKAB1 | huMAP3_01652.1 huMAP3_12203.1 |
| PRKAG3 | huMAP3_01652.1 huMAP3_12203.1 |