hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12214.1
Complex Portal: CPX-19608
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| AFF3 | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | 5 | UniProt NCBI |
| MEX3C | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | 5 | UniProt NCBI |
| PNISR | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | 5 | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | 5 | UniProt NCBI |
| GRM3 | Metabotropic glutamate receptor 3 (mGluR3) | 5 | UniProt NCBI |
| BRD2 | Bromodomain-containing protein 2 (O27.1.1) | 5 | UniProt NCBI |
| RTF1 | RNA polymerase-associated protein RTF1 homolog | 5 | UniProt NCBI |
| NSD3 | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 3.28565687076e-07 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | Synthesis of PIPs in the nucleus |
| WP:WP5411 | 1.99966829504e-06 | 0.363636363636 | PIP4K2A PIP4K2C PLCD3 PIP4K2B | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 1.99966829504e-06 | 0.363636363636 | PIP4K2A PIP4K2C PLCD3 PIP4K2B | Phosphoinositides metabolism |
| KEGG:00562 | 5.85403646388e-06 | 0.363636363636 | PIP4K2A PIP4K2C PLCD3 PIP4K2B | Inositol phosphate metabolism |
| REAC:R-HSA-6811555 | 6.88572370608e-06 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | PI5P Regulates TP53 Acetylation |
| GO:0016309 | 1.58598067776e-05 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902633 | 1.58598067776e-05 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 1.58598067776e-05 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| KEGG:04070 | 1.73732336667e-05 | 0.363636363636 | PIP4K2A PIP4K2C PLCD3 PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-6804758 | 0.000329950651236 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | Regulation of TP53 Activity through Acetylation |
| GO:0016308 | 0.000886327111509 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-1660499 | 0.00130859353099 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | Synthesis of PIPs at the plasma membrane |
| REAC:R-HSA-1483255 | 0.00476386518789 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | PI Metabolism |
| REAC:R-HSA-6811558 | 0.00517368811151 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.00678991252121 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | Negative regulation of the PI3K/AKT network |
| GO:2000786 | 0.0107228250299 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | positive regulation of autophagosome assembly |
| WP:WP51 | 0.010736478227 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | Regulation of actin cytoskeleton |
| KEGG:04810 | 0.0181775804342 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | Regulation of actin cytoskeleton |
| GO:0044090 | 0.0242342063386 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | positive regulation of vacuole organization |
| GO:0052742 | 0.0278578876014 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | phosphatidylinositol kinase activity |
| GO:0046627 | 0.0361493524666 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | negative regulation of insulin receptor signaling pathway |
| GO:1900077 | 0.0408476954791 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | negative regulation of cellular response to insulin stimulus |
| REAC:R-HSA-5633007 | 0.0443476855597 | 0.272727272727 | PIP4K2A PIP4K2C PIP4K2B | Regulation of TP53 Activity |
| CORUM:6371 | 0.049976851631 | 0.0909090909091 | GRM3 | mGluR3-mGluR8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | |
| PIP4K2A | PIP4K2C | 1.0 | 0.0883043478261 | |
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | |
| PIP4K2A | PLCD3 | 0.999 | 0.068 |
structurally_consistent (dimer)
|
| PLCD3 | PIP4K2C | 0.994 | 0.15 |
structurally_consistent (O43865)
structurally_consistent (dimer) |
| PIP4K2A | PNISR | 0.99 | 0.024 | |
| PIP4K2A | GRM3 | 0.983 | ||
| PIP4K2A | BRD2 | 0.975 | 0.012 | |
| PIP4K2A | RTF1 | 0.973 | 0.114 | |
| PIP4K2A | AFF3 | 0.963 | ||
| PIP4K2A | MEX3C | 0.96 | 0.106 | |
| NSD3 | BRD2 | 0.956 | 0.274 | |
| PIP4K2B | PLCD3 | 0.95 | 0.068 |
structurally_consistent (O43865)
structurally_consistent (dimer) |
| PLCD3 | BRD2 | 0.934 | 0.074 | |
| PLCD3 | PNISR | 0.902 | 0.066 | |
| PLCD3 | RTF1 | 0.83 | 0.064 |
structurally_consistent (dimer)
|
| RTF1 | BRD2 | 0.812 | 0.134 | |
| PIP4K2C | RTF1 | 0.809 | 0.024 | |
| PNISR | BRD2 | 0.798 | 0.194 | |
| GRM3 | AFF3 | 0.572 | ||
| GRM3 | MEX3C | 0.572 | ||
| PNISR | GRM3 | 0.502 | ||
| PIP4K2B | GRM3 | 0.333 | ||
| AFF3 | MEX3C | 0.303 | ||
| RTF1 | GRM3 | 0.303 | ||
| GRM3 | BRD2 | 0.303 | ||
| RTF1 | AFF3 | 0.262 | ||
| PIP4K2C | BRD2 | 0.256 | 0.032 | |
| PIP4K2C | MEX3C | 0.244 | 0.08 | |
| PIP4K2B | AFF3 | 0.213 | ||
| PIP4K2B | MEX3C | 0.213 | 0.098 | |
| PIP4K2B | BRD2 | 0.199 | 0.03 | |
| PLCD3 | AFF3 | 0.193 | ||
| PLCD3 | MEX3C | 0.193 | 0.072 | |
| PNISR | AFF3 | 0.172 | ||
| PNISR | MEX3C | 0.172 | 0.076 | |
| AFF3 | BRD2 | 0.165 | ||
| MEX3C | BRD2 | 0.165 | 0.112 | |
| RTF1 | MEX3C | 0.164 | 0.138 | |
| PIP4K2C | GRM3 | 0.143 | ||
| PLCD3 | GRM3 | 0.142 | ||
| PIP4K2C | AFF3 | 0.134 | ||
| RTF1 | PNISR | 0.107 | 0.254 | |
| PIP4K2B | PNISR | 0.082 | 0.022 | |
| PIP4K2C | PNISR | 0.075 | 0.054 | |
| PIP4K2B | RTF1 | 0.05 | 0.03 | |
| PIP4K2B | NSD3 | 0.022 | 0.03 | |
| PIP4K2C | NSD3 | 0.011 | 0.048 | |
| PNISR | NSD3 | 0.01 | 0.156 | |
| RTF1 | NSD3 | 0.009 | 0.11 | |
| PIP4K2A | NSD3 | 0.006 | 0.056 |
Related Complexes