hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12239.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LIX1L | LIX1-like protein | 2 | UniProt NCBI |
| CAPNS2 | Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) | 5 | UniProt NCBI |
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | 4 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| WNT8B | Protein Wnt-8b | 5 | UniProt NCBI |
| CAST | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | 5 | UniProt NCBI |
| THAP10 | THAP domain-containing protein 10 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1474228 | 1.67817647229e-05 | 0.571428571429 | CAPNS2 CAST CAPN8 CAPNS1 | Degradation of the extracellular matrix |
| REAC:R-HSA-8862803 | 1.72785870928e-05 | 0.428571428571 | CAPNS2 CAST CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 1.72785870928e-05 | 0.428571428571 | CAPNS2 CAST CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-9734009 | 2.62784267685e-05 | 0.428571428571 | CAPNS2 CAST CAPNS1 | Defective Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-1474244 | 0.000377209111577 | 0.571428571429 | CAPNS2 CAST CAPN8 CAPNS1 | Extracellular matrix organization |
| GO:0004198 | 0.000554182028596 | 0.428571428571 | CAPNS2 CAPN8 CAPNS1 | calcium-dependent cysteine-type endopeptidase activity |
| REAC:R-HSA-9645723 | 0.00155569177621 | 0.428571428571 | CAPNS2 CAST CAPNS1 | Diseases of programmed cell death |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LIX1L | CAPNS2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAST | CAPN8 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAST | CAPNS1 | 0.997 | 0.186 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CAST | CAPNS2 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| THAP10 | CAPNS2 | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAPN8 | CAPNS1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAST | LIX1L | 0.959 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
| CAPNS1 | CAPNS2 | 0.888 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAPNS2 | WNT8B | 0.885 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| LIX1L | CAPNS1 | 0.641 | 0.038 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CAPNS1 | THAP10 | 0.004 | bioplex3_HCT116 WMM_only |
Related Complexes