hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12248.1

Complex Portal: CPX-25485

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
PDHA2	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)	5	UniProt NCBI
FOXD4L1	Forkhead box protein D4-like 1 (FOXD4-like 1)	5	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	5	UniProt NCBI
SLX4IP	Protein SLX4IP (SLX4-interacting protein)	3	UniProt NCBI
PPM1K	Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial)	5	UniProt NCBI
BCKDHA	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)	5	UniProt NCBI
KGD4	Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4)	3	UniProt NCBI
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	5	UniProt NCBI
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	5	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	5	UniProt NCBI
BCKDHB	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)	5	UniProt NCBI
DBT	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)	5	UniProt NCBI
STAT5A	Signal transducer and activator of transcription 5A	5	UniProt NCBI
PDK4	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)	5	UniProt NCBI
HDAC6	Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)	5	UniProt NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	5	UniProt NCBI
CA5A	Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)	5	UniProt NCBI
DLD	Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)	5	UniProt NCBI
STAT5B	Signal transducer and activator of transcription 5B	5	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	5	UniProt NCBI
FOXD4	Forkhead box protein D4 (Forkhead-related protein FKHL9) (Forkhead-related transcription factor 5) (FREAC-5) (Myeloid factor-alpha)	4	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0006086	1.90841748077e-18	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-204174	3.3568955831e-18	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	Regulation of pyruvate dehydrogenase (PDH) complex
GO:0006085	1.02658468376e-15	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	acetyl-CoA biosynthetic process
REAC:R-HSA-70268	1.51365968075e-15	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	Pyruvate metabolism
REAC:R-HSA-5362517	9.94213740702e-15	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	Signaling by Retinoic Acid
GO:0006084	6.56124649302e-14	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	acetyl-CoA metabolic process
REAC:R-HSA-71406	1.92024907528e-13	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0035384	2.03888315848e-12	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	thioester biosynthetic process
GO:0071616	2.03888315848e-12	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	acyl-CoA biosynthetic process
GO:0033866	1.56367713703e-11	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	nucleoside bisphosphate biosynthetic process
GO:0034033	1.56367713703e-11	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	purine nucleoside bisphosphate biosynthetic process
GO:0034030	1.56367713703e-11	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	ribonucleoside bisphosphate biosynthetic process
GO:0005759	1.31422137408e-10	0.666666666667	PDK4 PDK2 PDK3 PPM1K PDHA1 PDHX PDHA2 CA5A BCKDHB PDK1 DLD KGD4	mitochondrial matrix
GO:0035383	8.56650026168e-10	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	thioester metabolic process
GO:0006637	8.56650026168e-10	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	acyl-CoA metabolic process
GO:0005967	1.61774021211e-09	0.277777777778	PDHA2 PDK2 DLD PDHA1 PDHX	mitochondrial pyruvate dehydrogenase complex
GO:0045254	1.61774021211e-09	0.277777777778	PDHA2 PDK2 DLD PDHA1 PDHX	pyruvate dehydrogenase complex
GO:0006790	2.50707538695e-09	0.555555555556	PDK4 STAT5A PDK3 PDHA1 DLD PDHA2 PDK2 PDK1 PDHX STAT5B	sulfur compound metabolic process
GO:0006090	2.59926327677e-09	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	pyruvate metabolic process
REAC:R-HSA-1428517	3.31327622434e-09	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	The citric acid (TCA) cycle and respiratory electron transport
GO:0034032	5.81210847858e-09	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	purine nucleoside bisphosphate metabolic process
GO:0033875	5.81210847858e-09	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	ribonucleoside bisphosphate metabolic process
GO:0033865	5.81210847858e-09	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	nucleoside bisphosphate metabolic process
REAC:R-HSA-389661	2.49294856598e-08	0.277777777778	PDHA2 DLD PDHA1 BCKDHB PDHX	Glyoxylate metabolism and glycine degradation
GO:0006082	2.52194573387e-08	0.666666666667	STAT5A PDK4 PDK3 PDK2 PDHA1 KGD4 PDHA2 BCKDHB PDK1 DLD PDHX STAT5B	organic acid metabolic process
GO:0044272	6.81341853098e-08	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	sulfur compound biosynthetic process
REAC:R-HSA-9006931	6.93745419783e-08	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	Signaling by Nuclear Receptors
GO:0010510	8.0516650888e-08	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0050812	8.0516650888e-08	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of acyl-CoA biosynthetic process
GO:0016903	2.5725700867e-07	0.333333333333	KGD4 PDHA1 PDHX PDHA2 BCKDHB DLD	oxidoreductase activity, acting on the aldehyde or oxo group of donors
KEGG:00785	2.86764221021e-07	0.222222222222	PDHA2 DLD PDHA1 BCKDHB	Lipoic acid metabolism
GO:0009152	2.9607423132e-07	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	purine ribonucleotide biosynthetic process
GO:0004740	4.02274655956e-07	0.222222222222	PDK3 PDK4 PDK2 PDK1	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0009260	4.64518625986e-07	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	ribonucleotide biosynthetic process
GO:0046390	6.18585294603e-07	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	ribose phosphate biosynthetic process
GO:0004738	1.20589885889e-06	0.222222222222	PDHA2 DLD PDHA1 PDHX	pyruvate dehydrogenase activity
GO:0006164	1.21265408703e-06	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	purine nucleotide biosynthetic process
GO:0072522	1.49905844128e-06	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	purine-containing compound biosynthetic process
GO:1990204	1.90588251036e-06	0.388888888889	DLD PDK2 PDHA1 KGD4 PDHA2 BCKDHB PDHX	oxidoreductase complex
KEGG:01210	2.54469059831e-06	0.222222222222	PDHA2 DLD PDHA1 BCKDHB	2-Oxocarboxylic acid metabolism
GO:0009165	2.84864876693e-06	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	nucleotide biosynthetic process
GO:0044281	2.96149060646e-06	0.722222222222	STAT5A PDK4 PDK3 PDK2 PDHA1 KGD4 PDHA2 CA5A BCKDHB PDK1 DLD PDHX STAT5B	small molecule metabolic process
GO:1901293	3.31802847252e-06	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	nucleoside phosphate biosynthetic process
GO:0016624	5.61890325943e-06	0.222222222222	PDHA2 KGD4 BCKDHB PDHA1	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0042762	1.68308738937e-05	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of sulfur metabolic process
HP:0003112	1.99496580402e-05	0.333333333333	PPM1K PDHA1 PDHX CA5A BCKDHB DLD	Abnormal circulating amino acid concentration
GO:0019752	2.37354500958e-05	0.555555555556	PDK4 PDK3 PDK2 PDHA1 KGD4 PDHA2 BCKDHB PDK1 DLD PDHX	carboxylic acid metabolic process
GO:0043436	3.0094426096e-05	0.555555555556	PDK4 PDK3 PDK2 PDHA1 KGD4 PDHA2 BCKDHB PDK1 DLD PDHX	oxoacid metabolic process
GO:0009150	7.53876048527e-05	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	purine ribonucleotide metabolic process
GO:0009259	9.65491935061e-05	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	ribonucleotide metabolic process
GO:1900371	0.000108981935792	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of purine nucleotide biosynthetic process
GO:0030808	0.000108981935792	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of nucleotide biosynthetic process
GO:0005739	0.00011029207196	0.666666666667	PDK4 PDK2 PDK3 PPM1K PDHA1 PDHX PDHA2 CA5A BCKDHB PDK1 DLD KGD4	mitochondrion
KEGG:05415	0.000125262610256	0.277777777778	PDHA2 PDK4 PDK2 PDHA1 PDK3	Diabetic cardiomyopathy
GO:0019693	0.000128598436128	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	ribose phosphate metabolic process
WP:WP4206	0.000208632500506	0.166666666667	PDHA2 PDHA1 PDK1	Hereditary leiomyomatosis and renal cell carcinoma pathway
WP:WP581	0.000281403048196	0.166666666667	PDK1 STAT5B STAT5A	EPO receptor signaling
HP:0010892	0.000313709863123	0.166666666667	PPM1K DLD BCKDHB	Abnormal circulating branched chain amino acid concentration
WP:WP3925	0.000329204544849	0.222222222222	PDK4 DLD PDHA1 PDHX	Amino acid metabolism
GO:0006163	0.000345248763175	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	purine nucleotide metabolic process
REAC:R-HSA-1430728	0.000351152549395	0.611111111111	PDK4 PDK3 PPM1K PDHA1 PDK2 PDHA2 CA5A BCKDHB PDK1 DLD PDHX	Metabolism
KEGG:00020	0.000366926746633	0.166666666667	PDHA2 PDHA1 DLD	Citrate cycle (TCA cycle)
GO:0072521	0.000476476370934	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	purine-containing compound metabolic process
REAC:R-HSA-71291	0.000500287687906	0.333333333333	PPM1K PDHA1 PDHX PDHA2 BCKDHB DLD	Metabolism of amino acids and derivatives
REAC:R-HSA-70895	0.000635067062134	0.166666666667	PPM1K DLD BCKDHB	Branched-chain amino acid catabolism
GO:0032787	0.000661304415722	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	monocarboxylic acid metabolic process
GO:0009117	0.000712873270986	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	nucleotide metabolic process
HP:0004354	0.000770205514946	0.333333333333	PPM1K PDHA1 PDHX CA5A BCKDHB DLD	Abnormal circulating carboxylic acid concentration
GO:0006753	0.0007967525041	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	nucleoside phosphate metabolic process
GO:0090407	0.000905300830196	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	organophosphate biosynthetic process
HP:0500184	0.00106061974405	0.166666666667	DLD PDHA1 PDHX	Abnormal CSF amino acid concentration
KEGG:00620	0.00110421784374	0.166666666667	PDHA2 PDHA1 DLD	Pyruvate metabolism
HP:0500183	0.00128690379114	0.166666666667	DLD PDHA1 PDHX	Abnormal CSF carboxylic acid concentration
GO:0098798	0.00131913759766	0.388888888889	DLD PDK2 PDHA1 KGD4 PDHA2 BCKDHB PDHX	mitochondrial protein-containing complex
REAC:R-HSA-162582	0.0013433819089	0.611111111111	PDK4 STAT5A HDAC6 PDK3 PDHA1 DLD PDHA2 PDK2 PDK1 PDHX STAT5B	Signal Transduction
GO:0005947	0.00156505859778	0.166666666667	BCKDHB KGD4 DLD	mitochondrial alpha-ketoglutarate dehydrogenase complex
WP:WP5220	0.00164823750801	0.166666666667	DLD PDHA1 PDHX	Metabolic reprogramming in pancreatic cancer
WP:WP528	0.00168978635957	0.111111111111	PDHA2 PDHA1	Acetylcholine synthesis
HP:0033108	0.00181248059898	0.222222222222	BCKDHB CA5A PDHA1 PDHX	Abnormal circulating proteinogenic amino acid derivative concentration
GO:0055086	0.0020252247098	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	nucleobase-containing small molecule metabolic process
HP:0003128	0.0022641309488	0.277777777778	BCKDHB DLD CA5A PDHA1 PDHX	Lactic acidosis
GO:1901137	0.00241610116415	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	carbohydrate derivative biosynthetic process
REAC:R-HSA-9645135	0.0026492656232	0.111111111111	STAT5A STAT5B	STAT5 Activation
KEGG:00010	0.00333479801514	0.166666666667	PDHA2 PDHA1 DLD	Glycolysis / Gluconeogenesis
KEGG:05230	0.00420780948361	0.166666666667	PDHA2 PDHA1 PDK1	Central carbon metabolism in cancer
REAC:R-HSA-9027283	0.00441221993888	0.111111111111	STAT5A STAT5B	Erythropoietin activates STAT5
HP:0033107	0.0044920391131	0.222222222222	PPM1K DLD CA5A BCKDHB	Abnormal circulating proteinogenic amino acid concentration
WP:WP5050	0.00757633204899	0.111111111111	PDK1 PDHA1	TCA cycle in senescence
WP:WP4255	0.00845540912781	0.166666666667	PDK1 STAT5B STAT5A	Non small cell lung cancer
REAC:R-HSA-9020958	0.00925214188057	0.111111111111	STAT5A STAT5B	Interleukin-21 signaling
HP:0010912	0.0104678300234	0.111111111111	PPM1K DLD	Abnormal circulating isoleucine concentration
HP:0010913	0.0104678300234	0.111111111111	PPM1K DLD	Hyperisoleucinemia
HP:0008344	0.0104678300234	0.111111111111	BCKDHB DLD	Elevated circulating branched chain amino acid concentration
WP:WP5063	0.0110957429196	0.111111111111	STAT5A STAT5B	FOXP3 in COVID 19
REAC:R-HSA-8985947	0.0123271862547	0.111111111111	STAT5A STAT5B	Interleukin-9 signaling
REAC:R-HSA-9702518	0.0123271862547	0.111111111111	STAT5A STAT5B	STAT5 activation downstream of FLT3 ITD mutants
GO:0030062	0.012862104388	0.166666666667	BCKDHB KGD4 DLD	mitochondrial tricarboxylic acid cycle enzyme complex
GO:0045240	0.012862104388	0.166666666667	BCKDHB KGD4 DLD	dihydrolipoyl dehydrogenase complex
KEGG:04066	0.0134415922974	0.166666666667	PDHA2 PDHA1 PDK1	HIF-1 signaling pathway
WP:WP22	0.0152763590598	0.111111111111	STAT5A STAT5B	IL 9 signaling pathway
KEGG:01200	0.0155458881013	0.166666666667	PDHA2 PDHA1 DLD	Carbon metabolism
REAC:R-HSA-2586552	0.0158376732004	0.111111111111	STAT5A STAT5B	Signaling by Leptin
REAC:R-HSA-9020558	0.0158376732004	0.111111111111	STAT5A STAT5B	Interleukin-2 signaling
WP:WP2453	0.020115265883	0.111111111111	PDHA1 DLD	TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc
WP:WP205	0.0227806699533	0.111111111111	STAT5A STAT5B	IL 7 signaling pathway
GO:0043604	0.0239802570819	0.444444444444	PDK4 PDK3 PDK2 PDHA1 DLD PDHA2 PDK1 PDHX	amide biosynthetic process
HP:0500231	0.0261313881914	0.111111111111	PDHA1 PDHX	Abnormal CSF pyruvate family amino acid concentration
HP:0001942	0.0271184514598	0.222222222222	DLD CA5A PDHA1 PDHX	Metabolic acidosis
GO:0010906	0.0284162007118	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of glucose metabolic process
REAC:R-HSA-1170546	0.0289722176234	0.111111111111	STAT5A STAT5B	Prolactin receptor signaling
HP:0001423	0.0319604177977	0.166666666667	PDK3 PDHA1 HDAC6	X-linked dominant inheritance
GO:0019217	0.0327742146261	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of fatty acid metabolic process
REAC:R-HSA-9703648	0.0342149103932	0.111111111111	STAT5A STAT5B	Signaling by FLT3 ITD and TKD mutants
REAC:R-HSA-8983432	0.0342149103932	0.111111111111	STAT5A STAT5B	Interleukin-15 signaling
GO:1900542	0.0351308076483	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of purine nucleotide metabolic process
GO:0006140	0.037611258724	0.222222222222	PDK3 PDK4 PDK2 PDK1	regulation of nucleotide metabolic process
KEGG:00640	0.0383677260883	0.111111111111	BCKDHB DLD	Propanoate metabolism
HP:0004366	0.0407118524707	0.166666666667	DLD PDHA1 PDHX	Abnormality of glycolysis
HP:0003542	0.0407118524707	0.166666666667	DLD PDHA1 PDHX	Increased serum pyruvate
WP:WP4686	0.0421936103681	0.111111111111	BCKDHB DLD	Leucine isoleucine and valine metabolism
CORUM:2013	0.0496617483143	0.0555555555556	STAT5B	STAT5B homodimer complex
CORUM:2023	0.0496617483143	0.0555555555556	STAT5A	STAT5A homodimer complex
WP:WP4149	0.0499589979606	0.111111111111	STAT5A STAT5B	White fat cell differentiation

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PDHA1	PDHB	1.0	0.958	structurally_consistent (dimer)
STAT5A	PDHA1	1.0	0.158
STAT5A	DLAT	1.0	0.086
DLAT	DLD	1.0	0.514
PDK3	STAT5A	1.0	0.03
PDK3	FOXD4	1.0		structurally_consistent (Q15119) structurally_consistent (dimer)
PDHA1	DLAT	1.0	0.718
PDHB	DLAT	1.0	0.694
PDK3	DLAT	0.999	0.118	structurally_consistent (dimer)
BCKDHA	BCKDHB	0.999	0.724	structurally_consistent (dimer)
STAT5A	PDHB	0.999	0.124
PDK1	PDK2	0.999	0.058	structurally_consistent (dimer)
PDHB	DLD	0.999	0.66
PDK3	PDK1	0.999	0.278	structurally_consistent (dimer)
PDHX	DLD	0.999	0.436	structurally_consistent (dimer)
STAT5A	PDHX	0.999	0.04
PDK3	PDHB	0.999	0.124	structurally_consistent (dimer)
STAT5A	STAT5B	0.999	0.768	structurally_consistent (dimer)
PDHA1	DLD	0.998	0.766
DLD	KGD4	0.998	0.346	structurally_consistent (dimer)
PDHX	PDHA1	0.998	0.684
PDK3	PDHX	0.998	0.06	structurally_consistent (dimer)
PDHX	DLAT	0.997	0.652
PDK3	PDHA1	0.997	0.18	structurally_consistent (dimer)
FOXD4	FOXD4L1	0.997
PDHA1	PDK2	0.996	0.204
PDK3	PDK2	0.996	0.088	structurally_consistent (dimer)
FOXD4	PDHA1	0.996
PDK1	PDHA1	0.996	0.29
PDK2	DLAT	0.994	0.236	structurally_consistent (dimer)
PDHX	PDK2	0.994	0.07
FOXD4	PDK2	0.994		structurally_consistent (P11177) structurally_consistent (dimer)
STAT5B	PDHX	0.993	0.078
PDHB	KGD4	0.991	0.272
PDHX	PDHB	0.991	0.568
DLAT	KGD4	0.989	0.22
STAT5B	PDHA1	0.989	0.11
PDHA1	KGD4	0.988	0.29
PDK4	PDK3	0.987		structurally_consistent (dimer)
PDK3	PDHA2	0.986		structurally_consistent (dimer)
FOXD4	PDHX	0.986		mutually_exclusive (Q15120)
FOXD4	PDHB	0.984		structurally_consistent (Q15119) structurally_consistent (dimer)
PDK1	PDHX	0.984	0.218
FOXD4	DLAT	0.982		structurally_consistent (Q15119)
STAT5B	PDHB	0.981	0.086
DBT	KGD4	0.979	0.152
FOXD4	PDK1	0.977		structurally_consistent (Q15119)
DLD	BCKDHA	0.971	0.386
PDHX	HDAC6	0.967	0.078
DBT	PDK2	0.966	0.09
DBT	DLD	0.965	0.302
PDK1	PDHB	0.964	0.429538461538
PDHB	PDK2	0.957	0.354	structurally_consistent (dimer)
BCKDHA	HDAC6	0.952	0.1
DBT	DLAT	0.947	0.37
PDHA1	CA5A	0.947
PDK3	DLD	0.947	0.12	structurally_consistent (dimer)
PDHX	KGD4	0.946	0.144	mutually_exclusive (P09622)
DBT	BCKDHB	0.946	0.416	structurally_consistent (P12694)
BCKDHB	HDAC6	0.942	0.072
DBT	PDHX	0.938	0.316
PDHX	BCKDHB	0.938	0.35
PDK4	PDK2	0.927		mutually_exclusive (Q15120)
PDK2	DLD	0.927	0.191076923077	structurally_consistent (Q15120)
PDK1	DLAT	0.924	0.3708
PDHB	BCKDHA	0.913	0.544	mutually_exclusive (P21953) structurally_consistent (dimer)
DBT	HDAC6	0.892	0.102
DLD	SLX4IP	0.892	0.206
BCKDHA	KGD4	0.884	0.078
PDK2	BCKDHA	0.881	0.114	structurally_consistent (P11177)
STAT5B	DLAT	0.88	0.092
DLAT	BCKDHA	0.867	0.386
BCKDHA	PPM1K	0.852		structurally_consistent (dimer)
PDHA1	BCKDHA	0.852	0.644	mutually_exclusive (P21953) structurally_consistent (dimer)
BCKDHB	PPM1K	0.844		structurally_consistent (P12694)
PDHA2	PDHB	0.844		structurally_consistent (dimer)
DLAT	BCKDHB	0.831	0.536
DLAT	CA5A	0.816
DBT	PPM1K	0.801		mutually_exclusive (P12694)
PDK3	STAT5B	0.789	0.024
DBT	BCKDHA	0.783	0.296	structurally_consistent (dimer)
PDHX	BCKDHA	0.77	0.364
KGD4	CA5A	0.738
PDHA1	HDAC6	0.724	0.216
PDK4	PDK1	0.713
DBT	PDHB	0.7	0.458
PDHB	CA5A	0.647
PDHA2	DLAT	0.587		structurally_consistent (Q15120)
FOXD4L1	DLAT	0.508
PDHA2	PDHX	0.505
DLAT	HDAC6	0.482	0.312
PDHX	CA5A	0.469
PDHA1	BCKDHB	0.446	0.53	mutually_exclusive (P11177) structurally_consistent (dimer)
STAT5B	DLD	0.435	0.044
DBT	PDHA1	0.407	0.582
PDHA2	DLD	0.403
FOXD4L1	PDHA1	0.384
PDHA2	PDHA1	0.313		mutually_exclusive (P11177)
FOXD4L1	PDHX	0.31
FOXD4L1	PDHB	0.294
DLAT	SLX4IP	0.29	0.076
PDK2	HDAC6	0.256	0.128
PDK3	FOXD4L1	0.252
PDK2	BCKDHB	0.248	0.148
BCKDHB	KGD4	0.242	0.054
STAT5A	PDK2	0.239	0.110288
PDK2	KGD4	0.234	0.096
PDK1	DLD	0.23	0.533217391304
DLD	BCKDHB	0.228	0.266
DLD	HDAC6	0.217	0.36
PDHA1	SLX4IP	0.214	0.106
FOXD4L1	PDK1	0.213
PDK3	DBT	0.173	0.114
FOXD4L1	PDK2	0.172
PDHA2	PDK1	0.168		structurally_consistent (Q15120)
PDHA2	PDK2	0.143		structurally_consistent (Q15120)
STAT5B	PDK2	0.143	0.06
PDK3	KGD4	0.125	0.06
PDHB	HDAC6	0.114	0.192
PDHB	BCKDHB	0.114	0.568	structurally_consistent (dimer)
PDK1	BCKDHA	0.107	0.206
DBT	PDK1	0.104	0.134
DLD	PPM1K	0.091
PDHB	SLX4IP	0.082	0.068
PDK3	BCKDHA	0.075	0.052
DBT	STAT5B	0.074	0.066
HDAC6	KGD4	0.071	0.082
PDHX	SLX4IP	0.07	0.102
PDK3	SLX4IP	0.064	0.038
BCKDHA	CA5A	0.06
DBT	SLX4IP	0.05	0.076
STAT5A	DLD	0.049	0.052
DLAT	PPM1K	0.046
FOXD4	DLD	0.037
PDK1	BCKDHB	0.037	0.106
DLD	CA5A	0.033
KGD4	SLX4IP	0.031	0.074
FOXD4	BCKDHA	0.03
FOXD4L1	DLD	0.029
PDK1	KGD4	0.029	0.216
BCKDHA	SLX4IP	0.028	0.074
PDHA2	BCKDHA	0.015
PDK3	BCKDHB	0.013	0.064	structurally_consistent (P08559)
PDK4	PDHA1	0.007		structurally_consistent (dimer)
PDK3	HDAC6	0.007	0.032
PDK4	DLAT	0.005
PDK4	DLD	0.004		structurally_consistent (Q15120)

Related Complexes

Genename	Complexes
PDHA2	huMAP3_02577.1 huMAP3_11877.1 huMAP3_12045.1 huMAP3_12248.1 huMAP3_13797.1 huMAP3_13948.1 huMAP3_14339.1 huMAP3_14864.1
FOXD4L1	huMAP3_01427.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_11665.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_13510.1
PDK3	huMAP3_00016.1 huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
SLX4IP	huMAP3_11548.1 huMAP3_12248.1 huMAP3_14356.1 huMAP3_14760.1 huMAP3_14776.1
PPM1K	huMAP3_12248.1 huMAP3_12775.1 huMAP3_14495.1
BCKDHA	huMAP3_05959.1 huMAP3_06461.1 huMAP3_10105.1 huMAP3_12248.1
KGD4	huMAP3_07213.1 huMAP3_10702.1 huMAP3_11548.1 huMAP3_11871.1 huMAP3_12248.1 huMAP3_13605.1
PDHA1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHX	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
BCKDHB	huMAP3_05959.1 huMAP3_10105.1 huMAP3_12248.1 huMAP3_14495.1
DBT	huMAP3_03551.1 huMAP3_07213.1 huMAP3_10244.1 huMAP3_10702.1 huMAP3_12248.1 huMAP3_12775.1
STAT5A	huMAP3_03752.1 huMAP3_05442.1 huMAP3_07514.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK4	huMAP3_00016.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
HDAC6	huMAP3_06461.1 huMAP3_09251.1 huMAP3_10381.1 huMAP3_12248.1 huMAP3_14401.1
PDK2	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
CA5A	huMAP3_11377.1 huMAP3_11473.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_12936.1 huMAP3_14339.1 huMAP3_14864.1 huMAP3_15110.1
DLD	huMAP3_04997.1 huMAP3_07213.1 huMAP3_10702.1 huMAP3_11548.1 huMAP3_11871.1 huMAP3_12248.1 huMAP3_14864.1
STAT5B	huMAP3_03752.1 huMAP3_04704.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHB	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
FOXD4	huMAP3_01427.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1
DLAT	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12248.1

Complex Portal: CPX-25485