hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12259.1
Complex Portal: CPX-16019
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OPRL1 | Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) | 5 | UniProt NCBI |
| AIG1 | Androgen-induced gene 1 protein (AIG-1) (Fatty acid esters of hydroxy fatty acids hydrolase AIG1) (FAHFA hydrolase AIG1) (EC 3.1.-.-) | 5 | UniProt NCBI |
| GIPR | Gastric inhibitory polypeptide receptor (GIP-R) (Glucose-dependent insulinotropic polypeptide receptor) | 5 | UniProt NCBI |
| GCGR | Glucagon receptor (GL-R) | 5 | UniProt NCBI |
| SLC25A35 | Solute carrier family 25 member 35 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP334 | 0.0003876755558 | 0.4 | GIPR GCGR | GPCRs class B secretin like |
| KEGG:04080 | 0.000982001084064 | 0.6 | OPRL1 GCGR GIPR | Neuroactive ligand-receptor interaction |
| REAC:R-HSA-420092 | 0.00383489202506 | 0.4 | GIPR GCGR | Glucagon-type ligand receptors |
| REAC:R-HSA-500792 | 0.00602250685023 | 0.6 | OPRL1 GCGR GIPR | GPCR ligand binding |
| GO:0008528 | 0.018748745536 | 0.6 | OPRL1 GCGR GIPR | G protein-coupled peptide receptor activity |
| GO:0001653 | 0.0224016609185 | 0.6 | OPRL1 GCGR GIPR | peptide receptor activity |
| REAC:R-HSA-388396 | 0.024557290195 | 0.6 | OPRL1 GCGR GIPR | GPCR downstream signalling |
| REAC:R-HSA-373080 | 0.0343168520054 | 0.4 | GIPR GCGR | Class B/2 (Secretin family receptors) |
| REAC:R-HSA-372790 | 0.0361267714165 | 0.6 | OPRL1 GCGR GIPR | Signaling by GPCR |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GCGR | GIPR | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| OPRL1 | AIG1 | 0.979 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| AIG1 | GCGR | 0.977 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SLC25A35 | GCGR | 0.967 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SLC25A35 | GIPR | 0.415 | bioplex3_WMM WMM_only | ||
| AIG1 | GIPR | 0.25 | bioplex3_WMM WMM_only | ||
| SLC25A35 | AIG1 | 0.135 | 0.074 | bioplex3_WMM WMM_only |
Related Complexes