hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12267.1
Complex Portal: CPX-22382
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRRC14 | Leucine-rich repeat-containing protein 14 | 4 | UniProt NCBI |
| CUL2 | Cullin-2 (CUL-2) | 5 | UniProt NCBI |
| FEM1C | Protein fem-1 homolog C (FEM1c) (FEM1-gamma) | 5 | UniProt NCBI |
| FEM1B | Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) | 5 | UniProt NCBI |
| WAC | WW domain-containing adapter protein with coiled-coil | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140627 | 0.000158467845213 | 0.6 | CUL2 FEM1B FEM1C | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
| GO:0031462 | 0.00127603542925 | 0.6 | CUL2 FEM1B FEM1C | Cul2-RING ubiquitin ligase complex |
| REAC:R-HSA-8951664 | 0.00571342832938 | 0.6 | CUL2 FEM1B FEM1C | Neddylation |
| REAC:R-HSA-597592 | 0.0380600523345 | 0.8 | CUL2 WAC FEM1B FEM1C | Post-translational protein modification |
| CORUM:6736 | 0.0498708842806 | 0.2 | CUL2 | PRAME-Cullin2 ubiquitin ligase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CUL2 | FEM1B | 0.999 | 0.114 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| FEM1C | CUL2 | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| WAC | CUL2 | 0.957 | hein_WMM bioplex3_WMM WMM_only | ||
| CUL2 | LRRC14 | 0.945 | 0.136 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| FEM1C | FEM1B | 0.884 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FEM1B | LRRC14 | 0.439 | 0.154 | bioplex3_WMM WMM_only | |
| FEM1C | LRRC14 | 0.25 | bioplex3_WMM WMM_only | ||
| WAC | FEM1B | 0.081 | bioplex3_WMM WMM_only |
Related Complexes