hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12277.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDCA8 | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | 5 | UniProt NCBI |
| AURKC | Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) | 5 | UniProt NCBI |
| INCENP | Inner centromere protein | 5 | UniProt NCBI |
| BIRC5 | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | 5 | UniProt NCBI |
| LILRA5 | Leukocyte immunoglobulin-like receptor subfamily A member 5 (CD85 antigen-like family member F) (Immunoglobulin-like transcript 11) (ILT-11) (Leukocyte immunoglobulin-like receptor 9) (LIR-9) (CD antigen CD85f) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0032133 | 1.97323122031e-09 | 0.8 | INCENP CDCA8 BIRC5 AURKC | chromosome passenger complex |
| CORUM:1120 | 2.80233355908e-09 | 0.6 | CDCA8 BIRC5 INCENP | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| CORUM:1119 | 1.12081835382e-08 | 0.6 | CDCA8 BIRC5 INCENP | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1118 | 1.12081835382e-08 | 0.6 | CDCA8 BIRC5 INCENP | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| GO:0051256 | 4.33992010508e-08 | 0.8 | INCENP CDCA8 BIRC5 AURKC | mitotic spindle midzone assembly |
| GO:0000022 | 6.50952358374e-08 | 0.8 | INCENP CDCA8 BIRC5 AURKC | mitotic spindle elongation |
| GO:0051255 | 6.50952358374e-08 | 0.8 | INCENP CDCA8 BIRC5 AURKC | spindle midzone assembly |
| GO:0051231 | 9.40213012535e-08 | 0.8 | INCENP CDCA8 BIRC5 AURKC | spindle elongation |
| GO:0032467 | 6.09135077526e-06 | 0.8 | INCENP CDCA8 BIRC5 AURKC | positive regulation of cytokinesis |
| GO:0051781 | 1.19998568947e-05 | 0.8 | INCENP CDCA8 BIRC5 AURKC | positive regulation of cell division |
| GO:0008608 | 3.02226820342e-05 | 0.8 | INCENP CDCA8 BIRC5 AURKC | attachment of spindle microtubules to kinetochore |
| GO:1903490 | 3.362820138e-05 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of mitotic cytokinesis |
| REAC:R-HSA-4615885 | 3.5683276241e-05 | 0.6 | CDCA8 BIRC5 INCENP | SUMOylation of DNA replication proteins |
| CORUM:2579 | 4.09448956317e-05 | 0.4 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) |
| CORUM:2582 | 4.09448956317e-05 | 0.4 | CDCA8 BIRC5 | Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) |
| GO:1902423 | 5.37995977657e-05 | 0.6 | CDCA8 BIRC5 INCENP | regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:1902412 | 5.37995977657e-05 | 0.6 | CDCA8 BIRC5 INCENP | regulation of mitotic cytokinesis |
| GO:1902425 | 5.37995977657e-05 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:0090307 | 6.84426164966e-05 | 0.8 | INCENP CDCA8 BIRC5 AURKC | mitotic spindle assembly |
| CORUM:1087 | 8.18785830799e-05 | 0.4 | INCENP BIRC5 | BIRC5-AURKB-INCENP-EVI5 complex |
| GO:0032465 | 0.000142656289013 | 0.8 | INCENP CDCA8 BIRC5 AURKC | regulation of cytokinesis |
| GO:0051987 | 0.000158467845213 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of attachment of spindle microtubules to kinetochore |
| GO:0090235 | 0.000211268761872 | 0.6 | CDCA8 BIRC5 INCENP | regulation of metaphase plate congression |
| GO:0090267 | 0.000211268761872 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| GO:0090232 | 0.000274621184043 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of spindle checkpoint |
| GO:0051310 | 0.000349949920328 | 0.8 | INCENP CDCA8 BIRC5 AURKC | metaphase chromosome alignment |
| REAC:R-HSA-141444 | 0.000388335652279 | 0.6 | CDCA8 BIRC5 INCENP | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.000388335652279 | 0.6 | CDCA8 BIRC5 INCENP | Amplification of signal from the kinetochores |
| GO:0051303 | 0.000399224932149 | 0.8 | INCENP CDCA8 BIRC5 AURKC | establishment of chromosome localization |
| GO:0050000 | 0.000492677093958 | 0.8 | INCENP CDCA8 BIRC5 AURKC | chromosome localization |
| GO:0051225 | 0.000556087531591 | 0.8 | INCENP CDCA8 BIRC5 AURKC | spindle assembly |
| REAC:R-HSA-69618 | 0.000630278165562 | 0.6 | CDCA8 BIRC5 INCENP | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.000722460713996 | 0.6 | CDCA8 BIRC5 INCENP | EML4 and NUDC in mitotic spindle formation |
| GO:0051302 | 0.000727710984203 | 0.8 | INCENP CDCA8 BIRC5 AURKC | regulation of cell division |
| GO:1901978 | 0.000783132248318 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of cell cycle checkpoint |
| GO:1901970 | 0.000783132248318 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of mitotic sister chromatid separation |
| GO:0007052 | 0.000842045360476 | 0.8 | INCENP CDCA8 BIRC5 AURKC | mitotic spindle organization |
| REAC:R-HSA-2500257 | 0.000887870732144 | 0.6 | CDCA8 BIRC5 INCENP | Resolution of Sister Chromatid Cohesion |
| GO:0090266 | 0.000929874009882 | 0.6 | CDCA8 BIRC5 INCENP | regulation of mitotic cell cycle spindle assembly checkpoint |
| GO:1903504 | 0.000929874009882 | 0.6 | CDCA8 BIRC5 INCENP | regulation of mitotic spindle checkpoint |
| GO:0051988 | 0.00109385703544 | 0.6 | CDCA8 BIRC5 INCENP | regulation of attachment of spindle microtubules to kinetochore |
| GO:0090231 | 0.00109385703544 | 0.6 | CDCA8 BIRC5 INCENP | regulation of spindle checkpoint |
| REAC:R-HSA-5663220 | 0.00115380230305 | 0.6 | CDCA8 BIRC5 INCENP | RHO GTPases Activate Formins |
| GO:0005875 | 0.00118663084114 | 0.8 | INCENP CDCA8 BIRC5 AURKC | microtubule associated complex |
| GO:0051315 | 0.00194127795747 | 0.6 | CDCA8 BIRC5 INCENP | attachment of mitotic spindle microtubules to kinetochore |
| REAC:R-HSA-3108232 | 0.0019808748776 | 0.6 | CDCA8 BIRC5 INCENP | SUMO E3 ligases SUMOylate target proteins |
| GO:1902850 | 0.00200179443266 | 0.8 | INCENP CDCA8 BIRC5 AURKC | microtubule cytoskeleton organization involved in mitosis |
| REAC:R-HSA-2990846 | 0.00217510180244 | 0.6 | CDCA8 BIRC5 INCENP | SUMOylation |
| GO:0030496 | 0.00264419770945 | 0.8 | INCENP CDCA8 BIRC5 AURKC | midbody |
| REAC:R-HSA-2467813 | 0.0031285811726 | 0.6 | CDCA8 BIRC5 INCENP | Separation of Sister Chromatids |
| GO:0051984 | 0.00314081658857 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of chromosome segregation |
| GO:1905820 | 0.00314081658857 | 0.6 | CDCA8 BIRC5 INCENP | positive regulation of chromosome separation |
| GO:0000910 | 0.00326030759216 | 0.8 | INCENP CDCA8 BIRC5 AURKC | cytokinesis |
| GO:0000070 | 0.0035170104576 | 0.8 | INCENP CDCA8 BIRC5 AURKC | mitotic sister chromatid segregation |
| GO:0007051 | 0.00360584954209 | 0.8 | INCENP CDCA8 BIRC5 AURKC | spindle organization |
| REAC:R-HSA-68877 | 0.00372311058954 | 0.6 | CDCA8 BIRC5 INCENP | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.00556290465695 | 0.6 | CDCA8 BIRC5 INCENP | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00563783422619 | 0.6 | CDCA8 BIRC5 INCENP | Mitotic Metaphase and Anaphase |
| GO:0051233 | 0.00573353417253 | 0.6 | INCENP CDCA8 AURKC | spindle midzone |
| GO:0090068 | 0.00628821134931 | 0.8 | INCENP CDCA8 BIRC5 AURKC | positive regulation of cell cycle process |
| GO:0000775 | 0.00776216760564 | 0.8 | INCENP CDCA8 BIRC5 AURKC | chromosome, centromeric region |
| GO:0000819 | 0.00841882816967 | 0.8 | INCENP CDCA8 BIRC5 AURKC | sister chromatid segregation |
| GO:0071173 | 0.0102064666638 | 0.6 | CDCA8 BIRC5 INCENP | spindle assembly checkpoint signaling |
| GO:0071174 | 0.0102064666638 | 0.6 | CDCA8 BIRC5 INCENP | mitotic spindle checkpoint signaling |
| GO:1901976 | 0.0102064666638 | 0.6 | CDCA8 BIRC5 INCENP | regulation of cell cycle checkpoint |
| GO:0007094 | 0.0102064666638 | 0.6 | CDCA8 BIRC5 INCENP | mitotic spindle assembly checkpoint signaling |
| REAC:R-HSA-69620 | 0.0108605941756 | 0.6 | CDCA8 BIRC5 INCENP | Cell Cycle Checkpoints |
| GO:0045841 | 0.0109904490822 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of mitotic metaphase/anaphase transition |
| GO:0033048 | 0.0109904490822 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of mitotic sister chromatid segregation |
| GO:2000816 | 0.0109904490822 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of mitotic sister chromatid separation |
| GO:0033046 | 0.0109904490822 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of sister chromatid segregation |
| GO:0031577 | 0.0109904490822 | 0.6 | CDCA8 BIRC5 INCENP | spindle checkpoint signaling |
| GO:0051985 | 0.0126766174236 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of chromosome segregation |
| GO:1902100 | 0.0126766174236 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of metaphase/anaphase transition of cell cycle |
| GO:1905819 | 0.0126766174236 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of chromosome separation |
| REAC:R-HSA-195258 | 0.0129544055333 | 0.6 | CDCA8 BIRC5 INCENP | RHO GTPase Effectors |
| GO:0140014 | 0.0137548412893 | 0.8 | INCENP CDCA8 BIRC5 AURKC | mitotic nuclear division |
| GO:0051301 | 0.0163652485476 | 0.8 | INCENP CDCA8 BIRC5 AURKC | cell division |
| GO:0033047 | 0.016548216138 | 0.6 | CDCA8 BIRC5 INCENP | regulation of mitotic sister chromatid segregation |
| GO:0045839 | 0.0176256341648 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of mitotic nuclear division |
| GO:0098813 | 0.0180995584082 | 0.8 | INCENP CDCA8 BIRC5 AURKC | nuclear chromosome segregation |
| GO:0045787 | 0.0184014589883 | 0.8 | INCENP CDCA8 BIRC5 AURKC | positive regulation of cell cycle |
| GO:0051784 | 0.0211358171848 | 0.6 | CDCA8 BIRC5 INCENP | negative regulation of nuclear division |
| GO:0010965 | 0.0211358171848 | 0.6 | CDCA8 BIRC5 INCENP | regulation of mitotic sister chromatid separation |
| GO:0051306 | 0.0237169649094 | 0.6 | CDCA8 BIRC5 INCENP | mitotic sister chromatid separation |
| GO:0007080 | 0.0279690439474 | 0.6 | CDCA8 BIRC5 INCENP | mitotic metaphase chromosome alignment |
| REAC:R-HSA-68886 | 0.0287469323532 | 0.6 | CDCA8 BIRC5 INCENP | M Phase |
| GO:0006468 | 0.0389285508109 | 1.0 | INCENP LILRA5 CDCA8 BIRC5 AURKC | protein phosphorylation |
| GO:1905818 | 0.0437005530348 | 0.6 | CDCA8 BIRC5 INCENP | regulation of chromosome separation |
| GO:0140694 | 0.0488196060798 | 0.8 | INCENP CDCA8 BIRC5 AURKC | non-membrane-bounded organelle assembly |
| CORUM:2580 | 0.0498708842806 | 0.2 | BIRC5 | Survivin homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| INCENP | AURKC | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BIRC5 | CDCA8 | 0.999 | 0.59 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CDCA8 | INCENP | 0.998 | 0.606 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| BIRC5 | INCENP | 0.994 | 0.758 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CDCA8 | LILRA5 | 0.939 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC5 | LILRA5 | 0.478 | bioplex3_WMM WMM_only |
Related Complexes