hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12283.1
Complex Portal: CPX-12731
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM175 | Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175) (hTMEM175) | 5 | UniProt NCBI |
| SLC29A4 | Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (PMAT) (Solute carrier family 29 member 4) | 5 | UniProt NCBI |
| PLPP3 | Phospholipid phosphatase 3 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) | 5 | UniProt NCBI |
| PTPRJ | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) | 5 | UniProt NCBI |
| CD164L2 | CD164 sialomucin-like 2 protein | 3 | UniProt NCBI |
| SLC26A6 | Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1) | 5 | UniProt NCBI |
| SCAMP1 | Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) | 5 | UniProt NCBI |
| CSF3 | Granulocyte colony-stimulating factor (G-CSF) (Pluripoietin) (Filgrastim) (Lenograstim) | 5 | UniProt NCBI |
| SLC46A1 | Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) | 5 | UniProt NCBI |
| SPATA31D3 | Spermatogenesis-associated protein 31D3 (Protein FAM75D3) | 2 | UniProt NCBI |
| SLC29A2 | Equilibrative nucleoside transporter 2 (hENT2) (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2) | 5 | UniProt NCBI |
| SLC41A1 | Solute carrier family 41 member 1 | 5 | UniProt NCBI |
| TMEM184C | Transmembrane protein 184C (Transmembrane protein 34) | 3 | UniProt NCBI |
| STEAP2 | Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) | 5 | UniProt NCBI |
| TNFRSF10C | Tumor necrosis factor receptor superfamily member 10C (Antagonist decoy receptor for TRAIL/Apo-2L) (Decoy TRAIL receptor without death domain) (Decoy receptor 1) (DcR1) (Lymphocyte inhibitor of TRAIL) (TNF-related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (TRAIL receptor without an intracellular domain) (CD antigen CD263) | 5 | UniProt NCBI |
| PLPP2 | Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) | 5 | UniProt NCBI |
| PLPP1 | Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) | 5 | UniProt NCBI |
| SLC19A1 | Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016323 | 7.55666024409e-06 | 0.388888888889 | SLC41A1 PLPP3 SLC19A1 SLC29A4 SLC26A6 SLC29A2 SLC46A1 | basolateral plasma membrane |
| GO:0009925 | 1.90054208909e-05 | 0.388888888889 | SLC41A1 PLPP3 SLC19A1 SLC29A4 SLC26A6 SLC29A2 SLC46A1 | basal plasma membrane |
| GO:0045178 | 2.59272161632e-05 | 0.388888888889 | SLC41A1 PLPP3 SLC19A1 SLC29A4 SLC26A6 SLC29A2 SLC46A1 | basal part of cell |
| GO:0106235 | 7.84339535184e-05 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | ceramide-1-phosphate phosphatase activity |
| WP:WP325 | 0.000281403048196 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Triacylglyceride synthesis |
| WP:WP4726 | 0.000323364335236 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Sphingolipid metabolism integrated pathway |
| KEGG:04975 | 0.000366926746633 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Fat digestion and absorption |
| GO:0098590 | 0.000470320121905 | 0.5 | SLC41A1 PLPP3 SLC19A1 SLC29A4 PLPP2 SLC26A6 SLC29A2 PLPP1 SLC46A1 | plasma membrane region |
| KEGG:00565 | 0.000698445694946 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Ether lipid metabolism |
| KEGG:04978 | 0.00144638263255 | 0.166666666667 | SLC26A6 STEAP2 SLC46A1 | Mineral absorption |
| KEGG:00600 | 0.00144638263255 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Sphingolipid metabolism |
| GO:0042392 | 0.00156505859778 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | sphingosine-1-phosphate phosphatase activity |
| HP:0004851 | 0.00174718805299 | 0.111111111111 | SLC46A1 SLC19A1 | Folate-responsive megaloblastic anemia |
| KEGG:00561 | 0.00207997020079 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Glycerolipid metabolism |
| REAC:R-HSA-1660661 | 0.00282885520127 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Sphingolipid de novo biosynthesis |
| GO:0016324 | 0.00300451295016 | 0.333333333333 | SLC19A1 SLC29A4 SLC26A6 SLC29A2 SLC46A1 PLPP1 | apical plasma membrane |
| KEGG:00564 | 0.00688211028544 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Glycerophospholipid metabolism |
| GO:0045177 | 0.00716322931821 | 0.333333333333 | SLC19A1 SLC29A4 SLC26A6 SLC29A2 SLC46A1 PLPP1 | apical part of cell |
| KEGG:05231 | 0.00797164397956 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Choline metabolism in cancer |
| REAC:R-HSA-382551 | 0.00901069798332 | 0.333333333333 | SLC41A1 STEAP2 SLC29A4 SLC26A6 SLC29A2 SLC46A1 | Transport of small molecules |
| KEGG:04666 | 0.0101378090487 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Fc gamma R-mediated phagocytosis |
| REAC:R-HSA-425407 | 0.0115925952965 | 0.222222222222 | SLC26A6 SLC41A1 SLC29A4 SLC29A2 | SLC-mediated transmembrane transport |
| WP:WP4259 | 0.0152763590598 | 0.111111111111 | SLC46A1 SLC19A1 | Disorders of folate metabolism and transport |
| KEGG:04977 | 0.0158034483025 | 0.111111111111 | SLC46A1 SLC19A1 | Vitamin digestion and absorption |
| REAC:R-HSA-83936 | 0.0158376732004 | 0.111111111111 | SLC29A4 SLC29A2 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
| GO:0008195 | 0.0171362685288 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | phosphatidate phosphatase activity |
| KEGG:04072 | 0.0214383045914 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Phospholipase D signaling pathway |
| KEGG:01523 | 0.026914135528 | 0.111111111111 | SLC46A1 SLC19A1 | Antifolate resistance |
| GO:0006670 | 0.0283090922407 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | sphingosine metabolic process |
| REAC:R-HSA-428157 | 0.0285321317481 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | Sphingolipid metabolism |
| GO:0046519 | 0.035359119817 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | sphingoid metabolic process |
| GO:0042577 | 0.0434854095061 | 0.166666666667 | PLPP1 PLPP3 PLPP2 | lipid phosphatase activity |
| REAC:R-HSA-196757 | 0.0459913485254 | 0.111111111111 | SLC46A1 SLC19A1 | Metabolism of folate and pterines |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| TNFRSF10C | SLC41A1 | 0.999 | ||
| SLC19A1 | TNFRSF10C | 0.999 | ||
| PLPP2 | PLPP3 | 0.999 | 0.116 |
structurally_consistent (dimer)
|
| TNFRSF10C | PLPP3 | 0.999 | ||
| TNFRSF10C | SLC26A6 | 0.998 | ||
| SLC29A4 | TNFRSF10C | 0.998 | ||
| TMEM184C | TNFRSF10C | 0.998 | ||
| STEAP2 | TNFRSF10C | 0.996 | ||
| TNFRSF10C | SCAMP1 | 0.995 | ||
| TNFRSF10C | PTPRJ | 0.995 | ||
| CD164L2 | SLC19A1 | 0.99 | ||
| PTPRJ | CSF3 | 0.985 | ||
| PLPP1 | PLPP2 | 0.984 | 0.114 |
structurally_consistent (dimer)
|
| TNFRSF10C | SLC29A2 | 0.972 | ||
| TMEM175 | TNFRSF10C | 0.972 | ||
| TMEM184C | SLC26A6 | 0.939 | ||
| SLC26A6 | PLPP3 | 0.938 | ||
| SCAMP1 | SLC41A1 | 0.932 | ||
| TMEM184C | PLPP3 | 0.931 | 0.104 | |
| SLC26A6 | SLC41A1 | 0.926 | ||
| SPATA31D3 | STEAP2 | 0.904 | ||
| PLPP1 | PLPP3 | 0.904 | 0.15 |
mutually_exclusive (O43688)
|
| SLC29A4 | STEAP2 | 0.904 | ||
| SLC29A4 | TMEM184C | 0.902 | ||
| SLC29A4 | SLC26A6 | 0.902 | ||
| SPATA31D3 | SLC19A1 | 0.902 | ||
| SLC29A4 | SLC41A1 | 0.902 | ||
| SLC19A1 | SLC29A4 | 0.902 | ||
| SLC29A4 | PLPP3 | 0.902 | ||
| SLC26A6 | SLC46A1 | 0.896 | ||
| SLC29A4 | PTPRJ | 0.893 | ||
| SLC26A6 | SCAMP1 | 0.874 | ||
| SLC19A1 | SLC26A6 | 0.854 | ||
| SLC26A6 | PTPRJ | 0.848 | ||
| SLC19A1 | TMEM184C | 0.826 | 0.044 | |
| TMEM184C | SLC41A1 | 0.826 | ||
| STEAP2 | SCAMP1 | 0.814 | ||
| STEAP2 | SLC26A6 | 0.796 | ||
| SLC19A1 | SCAMP1 | 0.736 | 0.148 | |
| TMEM184C | STEAP2 | 0.73 | ||
| SLC19A1 | SLC41A1 | 0.72 | ||
| TMEM184C | PTPRJ | 0.711 | 0.034 | |
| STEAP2 | PLPP3 | 0.64 | ||
| SLC19A1 | STEAP2 | 0.612 | ||
| PLPP3 | SLC41A1 | 0.521 | ||
| SLC29A4 | SCAMP1 | 0.455 | ||
| SPATA31D3 | SCAMP1 | 0.455 | ||
| SLC29A2 | SLC46A1 | 0.428 | 0.108 | |
| PTPRJ | PLPP3 | 0.401 | 0.076 | |
| TMEM184C | SCAMP1 | 0.397 | 0.124 | |
| SLC26A6 | SLC29A2 | 0.385 | ||
| TMEM175 | SLC26A6 | 0.385 | ||
| STEAP2 | SLC41A1 | 0.364 | ||
| SLC19A1 | PLPP3 | 0.358 | 0.128 | |
| PTPRJ | SLC41A1 | 0.356 | ||
| SLC19A1 | PTPRJ | 0.356 | 0.08 | |
| STEAP2 | PTPRJ | 0.356 | ||
| PLPP3 | SCAMP1 | 0.332 | 0.066 | |
| TNFRSF10C | SLC46A1 | 0.33 | ||
| TMEM184C | SLC29A2 | 0.274 | 0.08 | |
| TMEM175 | TMEM184C | 0.274 | ||
| PTPRJ | PLPP2 | 0.248 | 0.102 | |
| TMEM175 | SLC29A4 | 0.214 | ||
| SLC29A4 | SLC29A2 | 0.214 | ||
| SLC29A2 | PLPP3 | 0.21 | 0.1 | |
| TMEM175 | PLPP3 | 0.21 | ||
| TMEM175 | SLC29A2 | 0.21 | ||
| PTPRJ | SCAMP1 | 0.16 | 0.058 | |
| STEAP2 | SLC46A1 | 0.123 | ||
| TMEM184C | SLC46A1 | 0.102 | 0.11 | |
| TMEM175 | SCAMP1 | 0.102 | ||
| SLC29A2 | SCAMP1 | 0.102 | 0.096 | |
| SLC29A2 | SLC41A1 | 0.095 | ||
| TMEM175 | SLC41A1 | 0.095 | ||
| TMEM175 | SLC19A1 | 0.095 | ||
| SLC19A1 | SLC29A2 | 0.095 | 0.122 | |
| TMEM175 | SLC46A1 | 0.095 | ||
| PLPP3 | SLC46A1 | 0.087 | 0.162 | |
| SLC19A1 | SLC46A1 | 0.081 | 0.16 | |
| SLC41A1 | SLC46A1 | 0.064 | ||
| STEAP2 | SLC29A2 | 0.043 | ||
| PTPRJ | SLC29A2 | 0.043 | 0.072 | |
| TMEM175 | PTPRJ | 0.043 | ||
| TMEM175 | STEAP2 | 0.043 | ||
| SLC29A4 | SLC46A1 | 0.043 | ||
| SCAMP1 | SLC46A1 | 0.032 | 0.072 | |
| PLPP1 | SLC46A1 | 0.027 | 0.078 | |
| PTPRJ | SLC46A1 | 0.026 | 0.072 |
Related Complexes