hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12321.1

Complex Portal: CPX-20240

Confidence: Medium

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Genename	Protein Name	Uniprot Annotation Score	Links
ALK	ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)	5	UniProt NCBI
GPR50	Melatonin-related receptor (G protein-coupled receptor 50) (H9) [Cleaved into: C-terminal domain]	5	UniProt NCBI

Showing 1 to 2 of 2 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9717264	0.0249718442457	0.5	ALK	ASP-3026-resistant ALK mutants
REAC:R-HSA-9700649	0.0249718442457	0.5	ALK	Drug resistance of ALK mutants
REAC:R-HSA-9717301	0.0249718442457	0.5	ALK	NVP-TAE684-resistant ALK mutants
REAC:R-HSA-9717316	0.0249718442457	0.5	ALK	alectinib-resistant ALK mutants
REAC:R-HSA-9717319	0.0249718442457	0.5	ALK	brigatinib-resistant ALK mutants
REAC:R-HSA-9717323	0.0249718442457	0.5	ALK	ceritinib-resistant ALK mutants
REAC:R-HSA-9717326	0.0249718442457	0.5	ALK	crizotinib-resistant ALK mutants
REAC:R-HSA-9717329	0.0249718442457	0.5	ALK	lorlatinib-resistant ALK mutants

Showing 1 to 8 of 8 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
GPR50	ALK	0.864			bioplex3_HEK293 bioplex3_WMM WMM_only

Showing 1 to 1 of 1 entries

Related Complexes

Genename	Complexes
GPR50	huMAP3_01430.1 huMAP3_02546.1 huMAP3_05214.1 huMAP3_06539.1 huMAP3_08260.1 huMAP3_09364.1 huMAP3_11136.1 huMAP3_11807.1 huMAP3_12321.1
ALK	huMAP3_12321.1 huMAP3_13555.1 huMAP3_13804.1 huMAP3_13917.1 huMAP3_14478.1 huMAP3_14611.1 huMAP3_14845.1