hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12323.1
Complex Portal: CPX-13059
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4EBP3 | Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3) | 5 | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | 5 | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | 5 | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | 5 | UniProt NCBI |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | 5 | UniProt NCBI |
| EIF4ENIF1 | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | 5 | UniProt NCBI |
| EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | 2 | UniProt NCBI |
| ANGEL1 | Protein angel homolog 1 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 1.74145466773e-09 | 0.625 | EIF4G3 EIF4E EIF4EBP2 EIF4EBP3 EIF4EBP1 | Translation factors |
| GO:0031369 | 4.05547131245e-08 | 0.625 | EIF4EBP1 EIF4EBP2 EIF4EBP3 ANGEL1 EIF4E | translation initiation factor binding |
| GO:0008190 | 1.28818969855e-07 | 0.5 | EIF4EBP1 EIF4EBP3 ANGEL1 EIF4EBP2 | eukaryotic initiation factor 4E binding |
| GO:0045182 | 2.19071902247e-07 | 0.75 | EIF4E1B EIF4EBP2 EIF4EBP1 EIF4E EIF4G3 EIF4EBP3 | translation regulator activity |
| GO:0016281 | 1.31435310045e-06 | 0.5 | EIF4G3 EIF4EBP3 EIF4E1B EIF4E | eukaryotic translation initiation factor 4F complex |
| GO:0034518 | 3.34342729474e-06 | 0.5 | EIF4G3 EIF4EBP3 EIF4E1B EIF4E | RNA cap binding complex |
| GO:0006417 | 4.77395628419e-05 | 0.75 | EIF4EBP2 EIF4ENIF1 EIF4E EIF4EBP1 EIF4G3 EIF4EBP3 | regulation of translation |
| GO:0006413 | 4.78619713005e-05 | 0.625 | EIF4G3 EIF4E EIF4EBP2 EIF4EBP3 EIF4EBP1 | translational initiation |
| WP:WP4566 | 0.000103690692565 | 0.375 | EIF4G3 EIF4E EIF4EBP1 | Translation inhibitors in chronically activated PDGFRA cells |
| GO:0034248 | 0.000129107941303 | 0.75 | EIF4EBP2 EIF4ENIF1 EIF4E EIF4EBP1 EIF4G3 EIF4EBP3 | regulation of amide metabolic process |
| KEGG:01521 | 0.000339227897214 | 0.375 | EIF4EBP1 EIF4E EIF4E1B | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04211 | 0.000445680989864 | 0.375 | EIF4EBP1 EIF4E EIF4E1B | Longevity regulating pathway |
| GO:0010608 | 0.000502047215784 | 0.75 | EIF4EBP2 EIF4ENIF1 EIF4E EIF4EBP1 EIF4G3 EIF4EBP3 | post-transcriptional regulation of gene expression |
| KEGG:04066 | 0.000815533872115 | 0.375 | EIF4EBP1 EIF4E EIF4E1B | HIF-1 signaling pathway |
| KEGG:04910 | 0.00168069600991 | 0.375 | EIF4EBP1 EIF4E EIF4E1B | Insulin signaling pathway |
| GO:0006446 | 0.00176352609787 | 0.5 | EIF4G3 EIF4EBP2 EIF4EBP3 EIF4EBP1 | regulation of translational initiation |
| KEGG:04150 | 0.00271802931306 | 0.375 | EIF4EBP1 EIF4E EIF4E1B | mTOR signaling pathway |
| GO:0006412 | 0.00311274701697 | 0.75 | EIF4EBP2 EIF4ENIF1 EIF4E EIF4EBP1 EIF4G3 EIF4EBP3 | translation |
| WP:WP516 | 0.00364416819939 | 0.25 | EIF4EBP1 EIF4E | Hypertrophy model |
| GO:0043043 | 0.00370939279375 | 0.75 | EIF4EBP2 EIF4ENIF1 EIF4E EIF4EBP1 EIF4G3 EIF4EBP3 | peptide biosynthetic process |
| GO:0000339 | 0.0043754188034 | 0.375 | EIF4G3 EIF4E EIF4E1B | RNA cap binding |
| WP:WP3879 | 0.00499769201238 | 0.25 | EIF4EBP1 EIF4E | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| GO:0045947 | 0.00610957850275 | 0.375 | EIF4EBP1 EIF4EBP3 EIF4EBP2 | negative regulation of translational initiation |
| GO:0017148 | 0.00796838205046 | 0.5 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4EBP2 | negative regulation of translation |
| GO:0043604 | 0.0106478350773 | 0.75 | EIF4EBP2 EIF4ENIF1 EIF4E EIF4EBP1 EIF4G3 EIF4EBP3 | amide biosynthetic process |
| GO:0006518 | 0.0115415693869 | 0.75 | EIF4EBP2 EIF4ENIF1 EIF4E EIF4EBP1 EIF4G3 EIF4EBP3 | peptide metabolic process |
| GO:0030371 | 0.0139126682532 | 0.375 | EIF4EBP1 EIF4EBP3 EIF4EBP2 | translation repressor activity |
| GO:0034249 | 0.0152505613645 | 0.5 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4EBP2 | negative regulation of amide metabolic process |
| REAC:R-HSA-166208 | 0.0153043597228 | 0.25 | EIF4EBP1 EIF4E | mTORC1-mediated signalling |
| KEGG:04151 | 0.0191136955138 | 0.375 | EIF4EBP1 EIF4E EIF4E1B | PI3K-Akt signaling pathway |
| WP:WP3932 | 0.0231589023106 | 0.375 | EIF4EBP1 EIF4E EIF4E1B | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP4172 | 0.0300698308207 | 0.375 | EIF4EBP1 EIF4E EIF4E1B | PI3K Akt signaling pathway |
| WP:WP585 | 0.0300948019252 | 0.25 | EIF4EBP1 EIF4E | Interferon type I signaling pathways |
| REAC:R-HSA-165159 | 0.0452582424141 | 0.25 | EIF4EBP1 EIF4E | MTOR signalling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4E | EIF4ENIF1 | 0.999 | 0.2115 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EIF4E | EIF4G3 | 0.999 | 0.21 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| EIF4E | EIF4EBP2 | 0.998 | 0.124 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4E | ANGEL1 | 0.998 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EIF4EBP1 | EIF4E | 0.998 | 0.1384 |
mutually_exclusive (A6NMX2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4E1B | EIF4E | 0.982 |
mutually_exclusive (Q13541)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4EBP2 | 0.982 | 0.042 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4EBP1 | 0.977 |
mutually_exclusive (P06730)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4G3 | 0.908 | 0.148 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E1B | EIF4EBP2 | 0.904 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4G3 | EIF4EBP2 | 0.902 | 0.03 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E | EIF4EBP3 | 0.886 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EIF4G3 | EIF4ENIF1 | 0.885 | 0.138 |
mutually_exclusive (P06730)
|
youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ANGEL1 | EIF4ENIF1 | 0.872 | 0.15 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP2 | ANGEL1 | 0.845 | 0.066 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP2 | EIF4ENIF1 | 0.834 | 0.178 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4G3 | 0.675 | bioplex3_WMM WMM_only | ||
| EIF4G3 | ANGEL1 | 0.663 | 0.066 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP1 | EIF4ENIF1 | 0.588 | 0.056 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| EIF4E1B | EIF4ENIF1 | 0.388 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4E1B | ANGEL1 | 0.367 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4EBP1 | ANGEL1 | 0.325 | 0.06 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
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