hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12325.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | 5 | UniProt NCBI |
| EPB41L3 | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | 5 | UniProt NCBI |
| AP3M2 | AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) | 5 | UniProt NCBI |
| AP3M1 | AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) | 5 | UniProt NCBI |
| AP3S1 | AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) | 5 | UniProt NCBI |
| AP3D1 | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | 5 | UniProt NCBI |
| AP3S2 | AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b) | 5 | UniProt NCBI |
| AP3B2 | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:59 | 2.58667790242e-23 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | AP3 adaptor complex |
| GO:0035654 | 1.41749949052e-20 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | clathrin-coated vesicle cargo loading, AP-3-mediated |
| GO:0035652 | 1.41749949052e-20 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | clathrin-coated vesicle cargo loading |
| CORUM:652 | 1.66372960626e-19 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | AP3-BLOC1 complex |
| GO:0030123 | 5.10238684012e-19 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | AP-3 adaptor complex |
| GO:0048490 | 4.50807811277e-16 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | anterograde synaptic vesicle transport |
| GO:0099517 | 4.50807811277e-16 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | synaptic vesicle transport along microtubule |
| GO:0099514 | 4.50807811277e-16 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | synaptic vesicle cytoskeletal transport |
| GO:0035459 | 3.72206279962e-14 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | vesicle cargo loading |
| GO:0048489 | 4.76395460095e-14 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | synaptic vesicle transport |
| GO:0030119 | 9.51601694825e-14 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | AP-type membrane coat adaptor complex |
| GO:0097479 | 1.45676017843e-13 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | synaptic vesicle localization |
| GO:0047496 | 3.18032372692e-13 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | vesicle transport along microtubule |
| GO:0008089 | 3.81615940916e-13 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | anterograde axonal transport |
| GO:0016183 | 5.04245888889e-13 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | synaptic vesicle coating |
| KEGG:04142 | 9.89895322985e-13 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | Lysosome |
| GO:0098930 | 2.50333216298e-12 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | axonal transport |
| GO:0008088 | 5.4571016695e-12 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | axo-dendritic transport |
| GO:0099518 | 7.81630227245e-12 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | vesicle cytoskeletal trafficking |
| GO:0016185 | 1.05855399355e-11 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0070142 | 1.05855399355e-11 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | synaptic vesicle budding |
| GO:0072384 | 1.87789276164e-11 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | organelle transport along microtubule |
| GO:0048475 | 8.24326304692e-11 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | coated membrane |
| GO:0030117 | 8.24326304692e-11 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | membrane coat |
| GO:0010970 | 2.05277464614e-09 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | transport along microtubule |
| GO:1903232 | 4.31077484224e-09 | 0.625 | AP3S2 AP3D1 AP3S1 AP3B1 AP3M1 | melanosome assembly |
| GO:0099111 | 4.76043038412e-09 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | microtubule-based transport |
| GO:0051650 | 9.26932481332e-09 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | establishment of vesicle localization |
| GO:0060155 | 1.02328314981e-08 | 0.625 | AP3S2 AP3D1 AP3S1 AP3B1 AP3M1 | platelet dense granule organization |
| GO:0030705 | 1.14204846201e-08 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | cytoskeleton-dependent intracellular transport |
| GO:0051648 | 1.18984676644e-08 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | vesicle localization |
| WP:WP5408 | 1.20125766468e-07 | 0.5 | AP3B2 AP3D1 AP3M2 AP3S1 | 15q25 copy number variation |
| GO:0006901 | 1.62855460324e-07 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | vesicle coating |
| GO:0048753 | 1.89090055946e-07 | 0.625 | AP3S2 AP3D1 AP3S1 AP3B1 AP3M1 | pigment granule organization |
| GO:0032438 | 1.89090055946e-07 | 0.625 | AP3S2 AP3D1 AP3S1 AP3B1 AP3M1 | melanosome organization |
| GO:0033363 | 2.51675649869e-07 | 0.625 | AP3S2 AP3D1 AP3S1 AP3B1 AP3M1 | secretory granule organization |
| GO:0005769 | 2.67725572175e-07 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | early endosome |
| GO:0007018 | 2.74807631192e-07 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | microtubule-based movement |
| GO:0016050 | 3.54928101551e-07 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | vesicle organization |
| GO:0140238 | 6.11859846001e-07 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | presynaptic endocytosis |
| GO:0048488 | 6.11859846001e-07 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | synaptic vesicle endocytosis |
| GO:0036465 | 1.58134940195e-06 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | synaptic vesicle recycling |
| GO:0033059 | 1.73918590284e-06 | 0.625 | AP3S2 AP3D1 AP3S1 AP3B1 AP3M1 | cellular pigmentation |
| GO:0051656 | 2.3296399422e-06 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | establishment of organelle localization |
| GO:0006900 | 6.97460549517e-06 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | vesicle budding from membrane |
| GO:0043473 | 7.48615828366e-06 | 0.625 | AP3S2 AP3D1 AP3S1 AP3B1 AP3M1 | pigmentation |
| GO:0051640 | 1.30490246652e-05 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | organelle localization |
| CORUM:2307 | 2.39226645298e-05 | 0.25 | AP3D1 AP3S2 | AP3D1-AP3S2 complex |
| CORUM:2308 | 2.39226645298e-05 | 0.25 | AP3S1 AP3D1 | AP3D1-AP3S1 complex |
| GO:0099504 | 4.78619713005e-05 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | synaptic vesicle cycle |
| GO:0099003 | 5.52231314818e-05 | 0.625 | AP3S2 AP3B2 AP3D1 AP3M2 AP3S1 | vesicle-mediated transport in synapse |
| GO:0007017 | 0.000202850678908 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | microtubule-based process |
| GO:0005768 | 0.000235535533194 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | endosome |
| GO:0010256 | 0.000919301017811 | 0.75 | AP3D1 EPB41L3 AP3M1 AP3S1 AP3S2 AP3B1 | endomembrane system organization |
| GO:0006897 | 0.00118574423283 | 0.75 | AP3D1 AP3M2 AP3M1 AP3B2 AP3S2 AP3S1 | endocytosis |
| GO:0098796 | 0.00148283497143 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | membrane protein complex |
| HP:0011125 | 0.00225842370351 | 0.25 | AP3B1 AP3D1 | Abnormality of dermal melanosomes |
| GO:0061024 | 0.00426135925956 | 0.75 | AP3D1 EPB41L3 AP3B2 AP3M2 AP3S2 AP3S1 | membrane organization |
| GO:0046907 | 0.00445185102023 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | intracellular transport |
| GO:0016192 | 0.00496175592273 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | vesicle-mediated transport |
| GO:0098657 | 0.00591614616058 | 0.75 | AP3D1 AP3M2 AP3M1 AP3B2 AP3S2 AP3S1 | import into cell |
| GO:0051641 | 0.0249008806409 | 1.0 | AP3D1 AP3B2 EPB41L3 AP3M1 AP3S1 AP3S2 AP3M2 AP3B1 | cellular localization |
| GO:0051649 | 0.0250941260125 | 0.875 | AP3D1 AP3B2 AP3M1 AP3S1 AP3M2 AP3S2 AP3B1 | establishment of localization in cell |
| HP:0001022 | 0.0270195830756 | 0.25 | AP3B1 AP3D1 | Albinism |
| HP:0001107 | 0.0472195728067 | 0.25 | AP3B1 AP3D1 | Ocular albinism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AP3M1 | AP3S1 | 1.0 | 0.522 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3S1 | AP3B2 | 1.0 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| AP3M1 | AP3B2 | 1.0 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| AP3B1 | AP3S1 | 1.0 | 0.262 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3B1 | AP3M1 | 1.0 | 0.782 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| AP3M1 | AP3D1 | 1.0 | 0.794 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3M2 | AP3S1 | 1.0 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| AP3S1 | AP3D1 | 0.999 | 0.482 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3B1 | AP3M2 | 0.999 | 0.28 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| EPB41L3 | AP3M2 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| AP3M2 | AP3M1 | 0.998 | 0.636 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| EPB41L3 | AP3B1 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| EPB41L3 | AP3M1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| AP3M2 | AP3D1 | 0.995 | 0.604 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| AP3B1 | AP3D1 | 0.993 | 0.806 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP3M1 | AP3S2 | 0.991 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| AP3B1 | AP3B2 | 0.991 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AP3M2 | AP3B2 | 0.98 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only |
| AP3M2 | AP3S2 | 0.978 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EPB41L3 | AP3D1 | 0.971 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| AP3S1 | AP3S2 | 0.94 | 0.064 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3D1 | AP3S2 | 0.938 | 0.136 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3D1 | AP3B2 | 0.921 | 0.038 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EPB41L3 | AP3B2 | 0.913 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EPB41L3 | AP3S1 | 0.859 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| AP3B1 | AP3S2 | 0.834 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3S2 | AP3B2 | 0.747 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
| EPB41L3 | AP3S2 | 0.741 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes