hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12337.1
Complex Portal: CPX-16687
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCKAP5L | Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) | 5 | UniProt NCBI |
| CAMSAP1 | Calmodulin-regulated spectrin-associated protein 1 | 5 | UniProt NCBI |
| DNAL1 | Dynein axonemal light chain 1 (LC1) | 5 | UniProt NCBI |
| KIFAP3 | Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) | 5 | UniProt NCBI |
| HAGH | Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II) | 5 | UniProt NCBI |
| KIF3C | Kinesin-like protein KIF3C | 5 | UniProt NCBI |
| KIF3A | Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) | 5 | UniProt NCBI |
| KIF3B | Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed] | 5 | UniProt NCBI |
| MFHAS1 | Malignant fibrous histiocytoma-amplified sequence 1 (Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1) | 5 | UniProt NCBI |
| LYG1 | Lysozyme g-like protein 1 (EC 3.2.1.-) | 3 | UniProt NCBI |
| NCKAP5 | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04814 | 3.51020956426e-06 | 0.454545454545 | DNAL1 KIF3B KIF3A KIFAP3 KIF3C | Motor proteins |
| REAC:R-HSA-5620924 | 1.10421836437e-05 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | Intraflagellar transport |
| GO:0005874 | 1.10894704965e-05 | 0.636363636364 | NCKAP5 KIF3B KIF3A NCKAP5L KIF3C KIFAP3 CAMSAP1 | microtubule |
| REAC:R-HSA-983189 | 1.39579030198e-05 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | Kinesins |
| GO:0016939 | 1.58598067776e-05 | 0.272727272727 | KIF3A KIFAP3 KIF3B | kinesin II complex |
| REAC:R-HSA-6811434 | 0.000126946395471 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | COPI-dependent Golgi-to-ER retrograde traffic |
| GO:0072383 | 0.000158467845213 | 0.272727272727 | KIF3A KIFAP3 KIF3B | plus-end-directed vesicle transport along microtubule |
| GO:0007017 | 0.000180574281561 | 0.727272727273 | NCKAP5 KIF3B DNAL1 NCKAP5L KIF3C KIF3A KIFAP3 CAMSAP1 | microtubule-based process |
| GO:0099513 | 0.000226333424287 | 0.636363636364 | NCKAP5 KIF3B KIF3A NCKAP5L KIF3C KIFAP3 CAMSAP1 | polymeric cytoskeletal fiber |
| GO:0072386 | 0.000316805542726 | 0.272727272727 | KIF3A KIFAP3 KIF3B | plus-end-directed organelle transport along microtubule |
| REAC:R-HSA-2132295 | 0.000319374391968 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | MHC class II antigen presentation |
| CORUM:905 | 0.000341558207359 | 0.181818181818 | KIF3A KIF3B | KIF3A/B-PAR-3-aPKC-PAR-6 complex |
| REAC:R-HSA-8856688 | 0.00042969008262 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | Golgi-to-ER retrograde transport |
| GO:0005871 | 0.000566266067171 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | kinesin complex |
| GO:0005875 | 0.000863181324731 | 0.454545454545 | DNAL1 KIF3B KIF3A KIFAP3 KIF3C | microtubule associated complex |
| REAC:R-HSA-983231 | 0.00103331929021 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | Factors involved in megakaryocyte development and platelet production |
| GO:0097542 | 0.00127355706465 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | ciliary tip |
| GO:0099512 | 0.00162522572838 | 0.636363636364 | NCKAP5 KIF3B KIF3A NCKAP5L KIF3C KIFAP3 CAMSAP1 | supramolecular fiber |
| GO:0099081 | 0.00177146960832 | 0.636363636364 | NCKAP5 KIF3B KIF3A NCKAP5L KIF3C KIFAP3 CAMSAP1 | supramolecular polymer |
| REAC:R-HSA-5617833 | 0.00215758360349 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | Cilium Assembly |
| REAC:R-HSA-6811442 | 0.00234405547967 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0015630 | 0.00357219135506 | 0.727272727273 | NCKAP5 KIF3B DNAL1 NCKAP5L KIF3C KIF3A KIFAP3 CAMSAP1 | microtubule cytoskeleton |
| REAC:R-HSA-1445148 | 0.00419024544076 | 0.272727272727 | KIF3A KIFAP3 KIF3B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| WP:WP4536 | 0.00484299012773 | 0.272727272727 | KIF3A KIFAP3 KIF3B | Genes related to primary cilium development based on CRISPR |
| REAC:R-HSA-1852241 | 0.00944836185617 | 0.363636363636 | KIF3A KIF3B KIFAP3 KIF3C | Organelle biogenesis and maintenance |
| GO:0000226 | 0.0285893467678 | 0.545454545455 | KIF3B DNAL1 CAMSAP1 KIF3A NCKAP5L NCKAP5 | microtubule cytoskeleton organization |
| GO:0099080 | 0.0351026219178 | 0.636363636364 | NCKAP5 KIF3B KIF3A NCKAP5L KIF3C KIFAP3 CAMSAP1 | supramolecular complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KIFAP3 | KIF3A | 1.0 | 0.47 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| KIF3B | KIF3A | 1.0 | 0.448 |
mutually_exclusive (Q92845)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3B | 1.0 | 0.376 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3C | 0.997 | 0.116 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| KIF3C | KIF3A | 0.994 | 0.202 |
mutually_exclusive (Q92845)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
| KIF3A | MFHAS1 | 0.985 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LYG1 | KIF3A | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MFHAS1 | CAMSAP1 | 0.983 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| KIF3C | KIF3B | 0.983 | 0.178 |
mutually_exclusive (Q92845)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| KIFAP3 | MFHAS1 | 0.979 | 0.126 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MFHAS1 | DNAL1 | 0.978 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| KIF3C | NCKAP5 | 0.972 |
mutually_exclusive (Q92845)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIFAP3 | NCKAP5 | 0.972 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NCKAP5 | NCKAP5L | 0.967 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| KIF3A | CAMSAP1 | 0.947 | 0.054 | bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| KIFAP3 | HAGH | 0.909 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NCKAP5 | KIF3B | 0.884 |
mutually_exclusive (Q92845)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIF3A | HAGH | 0.806 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KIF3B | MFHAS1 | 0.653 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF3C | MFHAS1 | 0.635 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF3C | HAGH | 0.617 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF3B | HAGH | 0.585 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF3B | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIFAP3 | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF3C | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIFAP3 | CAMSAP1 | 0.491 | 0.07 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| LYG1 | MFHAS1 | 0.476 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MFHAS1 | HAGH | 0.424 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF3B | CAMSAP1 | 0.384 | 0.082 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| KIFAP3 | NCKAP5L | 0.307 | 0.078 | bioplex3_WMM youn_WMM WMM_only | |
| CAMSAP1 | DNAL1 | 0.303 | 0.084 |
mutually_exclusive (Q9Y4C4)
|
bioplex3_WMM fraction |
| LYG1 | HAGH | 0.299 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NCKAP5 | HAGH | 0.219 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LYG1 | CAMSAP1 | 0.214 | bioplex3_WMM WMM_only | ||
| KIF3C | NCKAP5L | 0.21 | 0.144 | bioplex3_WMM WMM_only | |
| KIF3B | NCKAP5L | 0.11 | 0.068 | bioplex3_WMM youn_WMM WMM_only | |
| KIF3C | CAMSAP1 | 0.108 | 0.094 | bioplex3_WMM WMM_only | |
| NCKAP5L | HAGH | 0.07 | bioplex3_WMM WMM_only | ||
| CAMSAP1 | HAGH | 0.028 | bioplex3_WMM WMM_only | ||
| KIF3A | NCKAP5L | 0.018 | 0.142651162791 | youn_WMM WMM_only | |
| NCKAP5L | CAMSAP1 | 0.016 | 0.036 | youn_WMM gupta_WMM WMM_only |
Related Complexes