hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12347.1
Complex Portal: CPX-24453
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | 5 | UniProt NCBI |
| SLC2A7 | Solute carrier family 2, facilitated glucose transporter member 7 (Glucose transporter type 7) (GLUT-7) (hGLUT7) | 5 | UniProt NCBI |
| RNF10 | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| UBE2W | Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W) | 5 | UniProt NCBI |
| UBE2E3 | Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) | 5 | UniProt NCBI |
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
| ADAMTS3 | A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061631 | 1.60760388446e-07 | 0.555555555556 | UBE2D4 UBE2E3 UBE2D3 UBE2D1 UBE2W | ubiquitin conjugating enzyme activity |
| GO:0061650 | 3.65797757329e-07 | 0.555555555556 | UBE2D4 UBE2E3 UBE2D3 UBE2D1 UBE2W | ubiquitin-like protein conjugating enzyme activity |
| KEGG:04120 | 3.8606160329e-07 | 0.555555555556 | UBE2D4 UBE2E3 UBE2D3 UBE2D1 UBE2W | Ubiquitin mediated proteolysis |
| REAC:R-HSA-983168 | 9.28104816561e-07 | 0.666666666667 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF25 UBE2D1 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 3.16158043465e-06 | 0.666666666667 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF25 UBE2D1 | Class I MHC mediated antigen processing & presentation |
| GO:0004842 | 6.51362936228e-06 | 0.777777777778 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | ubiquitin-protein transferase activity |
| GO:0019787 | 1.12783874141e-05 | 0.777777777778 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | ubiquitin-like protein transferase activity |
| GO:0016755 | 1.43488620166e-05 | 0.777777777778 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | aminoacyltransferase activity |
| REAC:R-HSA-8852135 | 1.77357526438e-05 | 0.444444444444 | UBE2E3 UBE2D3 UBE2D1 UBE2W | Protein ubiquitination |
| GO:0000209 | 4.04721682877e-05 | 0.666666666667 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF25 UBE2D1 | protein polyubiquitination |
| GO:0070979 | 6.74377942697e-05 | 0.444444444444 | UBE2D4 UBE2D3 UBE2W UBE2E3 | protein K11-linked ubiquitination |
| GO:0016567 | 0.000112741043467 | 0.777777777778 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | protein ubiquitination |
| REAC:R-HSA-1280218 | 0.000152242058159 | 0.666666666667 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF25 UBE2D1 | Adaptive Immune System |
| REAC:R-HSA-8866652 | 0.000154071905864 | 0.333333333333 | UBE2E3 UBE2D1 UBE2W | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| GO:0016746 | 0.000196797887145 | 0.777777777778 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | acyltransferase activity |
| GO:0032446 | 0.000276452042119 | 0.777777777778 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | protein modification by small protein conjugation |
| GO:0070647 | 0.000549372842896 | 0.777777777778 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | protein modification by small protein conjugation or removal |
| KEGG:03083 | 0.000679986209508 | 0.333333333333 | UBE2D4 UBE2D1 UBE2D3 | Polycomb repressive complex |
| GO:0043687 | 0.000866567764445 | 0.777777777778 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | post-translational protein modification |
| GO:0085020 | 0.00292902387419 | 0.333333333333 | UBE2D4 UBE2D3 RNF25 | protein K6-linked ubiquitination |
| GO:0070936 | 0.00334782846127 | 0.444444444444 | UBE2D4 UBE2D3 UBE2D1 UBE2E3 | protein K48-linked ubiquitination |
| KEGG:04141 | 0.00483284608142 | 0.333333333333 | UBE2D4 UBE2D1 UBE2D3 | Protein processing in endoplasmic reticulum |
| GO:0006511 | 0.00537628237252 | 0.666666666667 | UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | ubiquitin-dependent protein catabolic process |
| GO:0019941 | 0.00591809375688 | 0.666666666667 | UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | modification-dependent protein catabolic process |
| GO:0043632 | 0.00673624890584 | 0.666666666667 | UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | modification-dependent macromolecule catabolic process |
| GO:0140096 | 0.0134563157587 | 0.888888888889 | UBE2E3 UBE2D4 ADAMTS3 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | catalytic activity, acting on a protein |
| REAC:R-HSA-168927 | 0.0135859457713 | 0.222222222222 | UBE2D1 UBE2D3 | TICAM1, RIP1-mediated IKK complex recruitment |
| KEGG:05131 | 0.0146549467572 | 0.333333333333 | UBE2D4 UBE2D1 UBE2D3 | Shigellosis |
| REAC:R-HSA-937041 | 0.0150906736209 | 0.222222222222 | UBE2D1 UBE2D3 | IKK complex recruitment mediated by RIP1 |
| GO:0006508 | 0.0158535879087 | 0.777777777778 | UBE2D4 ADAMTS3 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | proteolysis |
| GO:0051603 | 0.0183571145865 | 0.666666666667 | UBE2D4 UBE2W UBE2D3 RNF10 RNF25 UBE2D1 | proteolysis involved in protein catabolic process |
| REAC:R-HSA-9705462 | 0.0200751738188 | 0.222222222222 | UBE2D1 UBE2D3 | Inactivation of CSF3 (G-CSF) signaling |
| REAC:R-HSA-201451 | 0.0237893486791 | 0.222222222222 | UBE2D1 UBE2D3 | Signaling by BMP |
| REAC:R-HSA-9674555 | 0.0299458635385 | 0.222222222222 | UBE2D1 UBE2D3 | Signaling by CSF3 (G-CSF) |
| REAC:R-HSA-2173795 | 0.032153801025 | 0.222222222222 | UBE2D1 UBE2D3 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| REAC:R-HSA-168256 | 0.0342353908338 | 0.666666666667 | UBE2E3 UBE2D4 UBE2W UBE2D3 RNF25 UBE2D1 | Immune System |
| REAC:R-HSA-936440 | 0.0417623735111 | 0.222222222222 | UBE2D1 UBE2D3 | Negative regulators of DDX58/IFIH1 signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF25 | UBE2E3 | 0.999 | 0.06 |
mutually_exclusive (P61077)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D3 | 0.998 | 0.064 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D1 | 0.997 | 0.144 |
mutually_exclusive (Q969T4)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNF25 | UBE2D4 | 0.99 |
mutually_exclusive (Q96LR5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RNF10 | UBE2E3 | 0.981 | 0.064 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D3 | UBE2D1 | 0.975 | 0.369636363636 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D3 | RNF10 | 0.954 | 0.204 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RNF10 | UBE2D4 | 0.946 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RNF25 | SLC2A7 | 0.912 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UBE2D3 | UBE2D4 | 0.909 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| RNF10 | ADAMTS3 | 0.902 | bioplex3_WMM WMM_only | ||
| UBE2D1 | UBE2E3 | 0.869 | 0.295222222222 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| RNF10 | UBE2D1 | 0.869 | 0.3551 |
mutually_exclusive (Q969T4)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| RNF10 | UBE2W | 0.865 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D3 | UBE2E3 | 0.823 | 0.09 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| RNF25 | RNF10 | 0.531 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D4 | UBE2E3 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| UBE2D1 | UBE2D4 | 0.214 | bioplex3_WMM WMM_only | ||
| UBE2D3 | UBE2W | 0.06 | bioplex3_WMM WMM_only |
Related Complexes