hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12348.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | 5 | UniProt NCBI |
| IDH3B | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta) | 5 | UniProt NCBI |
| IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6949 | 2.33868713081e-10 | 1.0 | IDH3G IDH3A IDH3B | Isocitrate dehydrogenase [NAD], mitochondrial |
| WP:WP78 | 6.32531883213e-08 | 1.0 | IDH3G IDH3A IDH3B | TCA cycle aka Krebs or citric acid cycle |
| GO:0004449 | 9.61200410764e-08 | 1.0 | IDH3G IDH3A IDH3B | isocitrate dehydrogenase (NAD+) activity |
| GO:0005962 | 9.61200410764e-08 | 1.0 | IDH3G IDH3A IDH3B | mitochondrial isocitrate dehydrogenase complex (NAD+) |
| GO:0045242 | 9.61200410764e-08 | 1.0 | IDH3G IDH3A IDH3B | isocitrate dehydrogenase complex (NAD+) |
| KEGG:01210 | 2.12090960201e-07 | 1.0 | IDH3G IDH3A IDH3B | 2-Oxocarboxylic acid metabolism |
| KEGG:00020 | 2.12090960201e-07 | 1.0 | IDH3G IDH3A IDH3B | Citrate cycle (TCA cycle) |
| REAC:R-HSA-71403 | 6.20580847727e-07 | 1.0 | IDH3G IDH3A IDH3B | Citric acid cycle (TCA cycle) |
| GO:0006102 | 9.61200410764e-07 | 1.0 | IDH3G IDH3A IDH3B | isocitrate metabolic process |
| GO:0004448 | 9.61200410764e-07 | 1.0 | IDH3G IDH3A IDH3B | isocitrate dehydrogenase [NAD(P)+] activity |
| KEGG:01230 | 2.50251661292e-06 | 1.0 | IDH3G IDH3A IDH3B | Biosynthesis of amino acids |
| KEGG:01200 | 9.51295867401e-06 | 1.0 | IDH3G IDH3A IDH3B | Carbon metabolism |
| REAC:R-HSA-71406 | 1.03119073194e-05 | 1.0 | IDH3G IDH3A IDH3B | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0030062 | 1.58598067776e-05 | 1.0 | IDH3G IDH3A IDH3B | mitochondrial tricarboxylic acid cycle enzyme complex |
| GO:0072350 | 2.11464090368e-05 | 1.0 | IDH3G IDH3A IDH3B | tricarboxylic acid metabolic process |
| GO:0045239 | 6.5361627932e-05 | 1.0 | IDH3G IDH3A IDH3B | tricarboxylic acid cycle enzyme complex |
| GO:0006099 | 0.000194546963139 | 1.0 | IDH3G IDH3A IDH3B | tricarboxylic acid cycle |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | IDH3G IDH3A IDH3B | The citric acid (TCA) cycle and respiratory electron transport |
| HPA:0090183 | 0.00681655925187 | 1.0 | IDH3G IDH3A IDH3B | cerebellum; cells in granular layer[High] |
| GO:1902652 | 0.00851239083773 | 1.0 | IDH3G IDH3A IDH3B | secondary alcohol metabolic process |
| GO:0016616 | 0.0165038110528 | 1.0 | IDH3G IDH3A IDH3B | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| KEGG:01100 | 0.0189521995452 | 1.0 | IDH3G IDH3A IDH3B | Metabolic pathways |
| GO:0016614 | 0.0207446272651 | 1.0 | IDH3G IDH3A IDH3B | oxidoreductase activity, acting on CH-OH group of donors |
| GO:1990204 | 0.0219076797621 | 1.0 | IDH3G IDH3A IDH3B | oxidoreductase complex |
| HP:0007675 | 0.0322405218297 | 0.666666666667 | IDH3B IDH3A | Progressive night blindness |
| HP:0030786 | 0.0359423574679 | 0.666666666667 | IDH3B IDH3A | Photopsia |
| HP:0007994 | 0.0368991311611 | 0.666666666667 | IDH3B IDH3A | Peripheral visual field loss |
| HP:0007787 | 0.0418708017344 | 0.666666666667 | IDH3B IDH3A | Posterior subcapsular cataract |
| HPA:0570813 | 0.0443510461782 | 1.0 | IDH3G IDH3A IDH3B | testis; spermatogonia cells[High] |
| HP:0007737 | 0.047155317063 | 0.666666666667 | IDH3B IDH3A | Bone spicule pigmentation of the retina |
| HP:0000563 | 0.0482497424485 | 0.666666666667 | IDH3B IDH3A | Keratoconus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IDH3G | IDH3B | 1.0 | 0.538 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction |
| IDH3B | IDH3A | 0.999 | 0.846 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction treiber_WMM |
| IDH3G | IDH3A | 0.999 | 0.808 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| IDH3G | huMAP3_02315.1 huMAP3_09052.1 huMAP3_12348.1 |
| IDH3B | huMAP3_02315.1 huMAP3_12348.1 |
| IDH3A | huMAP3_02315.1 huMAP3_12348.1 |