hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12361.1
Complex Portal: CPX-12338
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RTL9 | Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) | 2 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| UGT1A10 | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | 5 | UniProt NCBI |
| UGT1A9 | UDP-glucuronosyltransferase 1A9 (UGT1A9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-9) (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (lugP4) | 5 | UniProt NCBI |
| FUT1 | Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Blood group H alpha 2-fucosyltransferase) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344) | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051552 | 3.94689465137e-10 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | flavone metabolic process |
| WP:WP698 | 1.73012748765e-09 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Glucuronidation |
| REAC:R-HSA-156588 | 2.63746755285e-09 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Glucuronidation |
| KEGG:00053 | 2.98288331003e-09 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Ascorbate and aldarate metabolism |
| KEGG:00040 | 5.15667350319e-09 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Pentose and glucuronate interconversions |
| GO:0009812 | 1.38095933257e-08 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | flavonoid metabolic process |
| KEGG:00860 | 1.66660913908e-08 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Porphyrin metabolism |
| KEGG:00140 | 3.71931812515e-08 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Steroid hormone biosynthesis |
| KEGG:00830 | 1.01579626091e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Retinol metabolism |
| KEGG:05204 | 1.19001694828e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 1.28507720159e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 1.7232523415e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Bile secretion |
| KEGG:00980 | 1.84837677782e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 3.11012631351e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Drug metabolism - other enzymes |
| WP:WP1604 | 3.30616249499e-07 | 0.5 | UGT1A10 UGT1A8 UGT1A9 | Codeine and morphine metabolism |
| GO:0052695 | 3.94651622678e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | cellular glucuronidation |
| GO:0019585 | 5.38102340533e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | glucuronate metabolic process |
| GO:0006063 | 5.38102340533e-07 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | uronic acid metabolic process |
| REAC:R-HSA-156580 | 2.27591507227e-06 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 2.39388120273e-06 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Drug ADME |
| WP:WP5224 | 2.67704255195e-06 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | 2q37 copy number variation syndrome |
| GO:0015020 | 4.18478989067e-06 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | glucuronosyltransferase activity |
| KEGG:01240 | 5.1720763341e-06 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Biosynthesis of cofactors |
| GO:0052696 | 7.68841921772e-06 | 0.5 | UGT1A9 UGT1A8 UGT1A7 | flavonoid glucuronidation |
| KEGG:05207 | 1.13794685426e-05 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Chemical carcinogenesis - receptor activation |
| GO:0001889 | 2.5973152006e-05 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | liver development |
| REAC:R-HSA-9749641 | 2.85755298292e-05 | 0.5 | UGT1A9 UGT1A8 UGT1A7 | Aspirin ADME |
| GO:0061008 | 2.90256325893e-05 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | hepaticobiliary system development |
| GO:0052697 | 3.84302573496e-05 | 0.5 | UGT1A9 UGT1A8 UGT1A7 | xenobiotic glucuronidation |
| GO:0016758 | 3.99218587905e-05 | 0.833333333333 | FUT1 UGT1A10 UGT1A7 UGT1A8 UGT1A9 | hexosyltransferase activity |
| REAC:R-HSA-211859 | 4.04138478388e-05 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Biological oxidations |
| GO:0042440 | 9.81259188038e-05 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | pigment metabolic process |
| GO:0016757 | 0.000195002899367 | 0.833333333333 | FUT1 UGT1A10 UGT1A7 UGT1A8 UGT1A9 | glycosyltransferase activity |
| GO:0001972 | 0.000548960443183 | 0.5 | UGT1A9 UGT1A8 UGT1A7 | retinoic acid binding |
| WP:WP229 | 0.00055327344683 | 0.333333333333 | UGT1A10 UGT1A9 | Irinotecan pathway |
| GO:0006805 | 0.000870570917794 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | xenobiotic metabolic process |
| WP:WP691 | 0.000914914863609 | 0.333333333333 | UGT1A10 UGT1A8 | Tamoxifen metabolism |
| WP:WP702 | 0.00108366806834 | 0.5 | UGT1A10 UGT1A7 UGT1A9 | Metapathway biotransformation Phase I and II |
| KEGG:01100 | 0.00157235036995 | 0.833333333333 | FUT1 UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Metabolic pathways |
| WP:WP5276 | 0.00210864528598 | 0.333333333333 | UGT1A10 UGT1A8 | Estrogen metabolism |
| GO:0071466 | 0.00217058422698 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | cellular response to xenobiotic stimulus |
| GO:0048732 | 0.00251106274586 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | gland development |
| GO:0005501 | 0.00254971303757 | 0.5 | UGT1A9 UGT1A8 UGT1A7 | retinoid binding |
| GO:0019840 | 0.00254971303757 | 0.5 | UGT1A9 UGT1A8 UGT1A7 | isoprenoid binding |
| GO:0008194 | 0.00269555949443 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | UDP-glycosyltransferase activity |
| GO:0042573 | 0.00440656064028 | 0.5 | UGT1A9 UGT1A8 UGT1A7 | retinoic acid metabolic process |
| REAC:R-HSA-9753281 | 0.00594265866298 | 0.333333333333 | UGT1A10 UGT1A9 | Paracetamol ADME |
| GO:0009410 | 0.00613403369529 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | response to xenobiotic stimulus |
| WP:WP2873 | 0.00666790414994 | 0.333333333333 | UGT1A9 UGT1A7 | Aryl hydrocarbon receptor pathway |
| GO:0046982 | 0.0127111069184 | 0.666666666667 | UGT1A10 UGT1A7 UGT1A8 UGT1A9 | protein heterodimerization activity |
| REAC:R-HSA-1430728 | 0.0258573248266 | 0.833333333333 | FUT1 UGT1A10 UGT1A7 UGT1A8 UGT1A9 | Metabolism |
| TF:M08190_1 | 0.043641782766 | 1.0 | RTL9 UGT1A10 UGT1A7 UGT1A9 UGT1A8 FUT1 | Factor: AR; motif: GGAACGGWACATGTTCT; match class: 1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UGT1A7 | UGT1A10 | 1.0 |
mutually_exclusive (O60656)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RTL9 | UGT1A7 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UGT1A7 | UGT1A9 | 0.999 |
mutually_exclusive (Q9HAW8)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UGT1A10 | UGT1A9 | 0.994 |
mutually_exclusive (Q9HAW7)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UGT1A7 | FUT1 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UGT1A8 | UGT1A7 | 0.972 |
mutually_exclusive (Q9HAW8)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RTL9 | UGT1A9 | 0.946 | bioplex3_WMM WMM_only | ||
| RTL9 | FUT1 | 0.904 | bioplex3_WMM WMM_only | ||
| UGT1A9 | FUT1 | 0.703 | bioplex3_WMM WMM_only | ||
| RTL9 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only | ||
| UGT1A8 | UGT1A10 | 0.415 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A9 | 0.415 |
mutually_exclusive (Q9HAW8)
|
bioplex3_WMM WMM_only | |
| RTL9 | UGT1A8 | 0.415 | bioplex3_WMM WMM_only | ||
| UGT1A8 | FUT1 | 0.146 | bioplex3_WMM WMM_only | ||
| UGT1A10 | FUT1 | 0.055 | bioplex3_WMM WMM_only |
Related Complexes