hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12373.1
Complex Portal: CPX-14871
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UTY | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | 5 | UniProt NCBI |
| PAGR1 | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | 5 | UniProt NCBI |
| KMT2D | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | 5 | UniProt NCBI |
| RPL38 | Large ribosomal subunit protein eL38 (60S ribosomal protein L38) | 5 | UniProt NCBI |
| TPX2 | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | 5 | UniProt NCBI |
| RARRES1 | Retinoic acid receptor responder protein 1 (Phorbol ester-induced gene 1 protein) (PERG-1) (RAR-responsive protein TIG1) (Tazarotene-induced gene 1 protein) | 5 | UniProt NCBI |
| PAXIP1 | PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044666 | 3.03561565333e-07 | 0.571428571429 | UTY KMT2D PAXIP1 PAGR1 | MLL3/4 complex |
| CORUM:6467 | 5.89237886406e-07 | 0.428571428571 | PAGR1 PAXIP1 KMT2D | MLL4 complex |
| REAC:R-HSA-9772755 | 0.000127854887848 | 0.428571428571 | PAGR1 PAXIP1 KMT2D | Formation of WDR5-containing histone-modifying complexes |
| CORUM:6340 | 0.000205125012531 | 0.285714285714 | KMT2D PAXIP1 | PITX2-MLL4-ASH2L-RBBP5-PTIP complex |
| WP:WP4949 | 0.000343498567435 | 0.428571428571 | PAGR1 PAXIP1 KMT2D | 16p11 2 proximal deletion syndrome |
| GO:0035097 | 0.000579396940492 | 0.571428571429 | UTY KMT2D PAXIP1 PAGR1 | histone methyltransferase complex |
| CORUM:6461 | 0.000737776422886 | 0.285714285714 | PAGR1 PAXIP1 | MLL3 complex |
| CORUM:5195 | 0.000922010129722 | 0.285714285714 | PAGR1 PAXIP1 | PTIP-HMT complex |
| CORUM:3075 | 0.00135166454364 | 0.285714285714 | KMT2D PAXIP1 | UTX-MLL2/3 complex |
| GO:0034708 | 0.00242637201585 | 0.571428571429 | UTY KMT2D PAXIP1 PAGR1 | methyltransferase complex |
| REAC:R-HSA-5619507 | 0.00246283493288 | 0.428571428571 | PAGR1 PAXIP1 KMT2D | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.00246283493288 | 0.428571428571 | PAGR1 PAXIP1 KMT2D | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| WP:WP5351 | 0.00718724508234 | 0.285714285714 | PAGR1 PAXIP1 | Kleefstra syndrome |
| REAC:R-HSA-212165 | 0.0103135924507 | 0.428571428571 | PAGR1 PAXIP1 KMT2D | Epigenetic regulation of gene expression |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PAGR1 | PAXIP1 | 0.999 | 0.176 | bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| PAGR1 | KMT2D | 0.998 | 0.106 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PAGR1 | UTY | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PAXIP1 | KMT2D | 0.975 | 0.172 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TPX2 | PAXIP1 | 0.952 | 0.29 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| UTY | PAXIP1 | 0.91 | bioplex3_WMM WMM_only | ||
| UTY | KMT2D | 0.902 | bioplex3_WMM WMM_only | ||
| UTY | RPL38 | 0.875 | bioplex3_WMM WMM_only | ||
| PAGR1 | RPL38 | 0.853 | 0.076 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TPX2 | RARRES1 | 0.816 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PAXIP1 | RPL38 | 0.186 | 0.134 | bioplex3_WMM youn_WMM fraction | |
| RPL38 | KMT2D | 0.181 | 0.038 | bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM | |
| TPX2 | RPL38 | 0.009 | 0.13 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| RPL38 | RARRES1 | 0.006 | bioplex3_HEK293 WMM_only | ||
| TPX2 | KMT2D | 0.005 | 0.156462264151 | youn_WMM gupta_WMM WMM_only |
Related Complexes