hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12375.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TDG | G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG) | 5 | UniProt NCBI |
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | 5 | UniProt NCBI |
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | 5 | UniProt NCBI |
| SUMO3 | Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065676 | 1.40306823124e-08 | 0.75 | SAE1 SUMO2 SUMO3 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-3065678 | 2.80599241523e-08 | 0.75 | SAE1 SUMO2 SUMO3 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 1.17833531486e-07 | 0.75 | SAE1 SUMO2 SUMO3 | Processing and activation of SUMO |
| REAC:R-HSA-2990846 | 2.72176702781e-06 | 1.0 | SAE1 SUMO3 TDG SUMO2 | SUMOylation |
| REAC:R-HSA-3108214 | 7.99206750774e-05 | 0.75 | SUMO3 TDG SUMO2 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-3065679 | 0.000153732433522 | 0.5 | SUMO3 SUMO2 | SUMO is proteolytically processed |
| REAC:R-HSA-3108232 | 0.000897810107574 | 0.75 | SUMO3 TDG SUMO2 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-3232118 | 0.00107524337392 | 0.5 | SUMO3 SUMO2 | SUMOylation of transcription factors |
| REAC:R-HSA-4090294 | 0.0013924419067 | 0.5 | SUMO3 SUMO2 | SUMOylation of intracellular receptors |
| HPA:0470673 | 0.0039388821921 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; melanocytes[High] |
| HPA:0570813 | 0.00430468776878 | 1.0 | SAE1 SUMO3 TDG SUMO2 | testis; spermatogonia cells[High] |
| REAC:R-HSA-73894 | 0.00653220236003 | 0.75 | SUMO3 TDG SUMO2 | DNA Repair |
| REAC:R-HSA-3899300 | 0.00718390333861 | 0.5 | SUMO3 SUMO2 | SUMOylation of transcription cofactors |
| REAC:R-HSA-5696395 | 0.008795277704 | 0.5 | SUMO3 SUMO2 | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-4615885 | 0.008795277704 | 0.5 | SUMO3 SUMO2 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-597592 | 0.0091733555377 | 1.0 | SAE1 SUMO3 TDG SUMO2 | Post-translational protein modification |
| GO:0016925 | 0.0100599149475 | 0.75 | SAE1 SUMO2 SUMO3 | protein sumoylation |
| HPA:0500653 | 0.0121011271968 | 0.75 | SUMO3 TDG SUMO2 | soft tissue 1; fibroblasts[High] |
| KEGG:03013 | 0.0125523722118 | 0.5 | SUMO3 SUMO2 | Nucleocytoplasmic transport |
| HPA:0460182 | 0.0136756650941 | 0.75 | SAE1 SUMO2 SUMO3 | skin 1; cells in granular layer[>=Medium] |
| KEGG:05418 | 0.0168426929383 | 0.5 | SUMO3 SUMO2 | Fluid shear stress and atherosclerosis |
| HPA:0470202 | 0.0206978936317 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; endothelial cells[>=Medium] |
| REAC:R-HSA-4551638 | 0.0218635493976 | 0.5 | SUMO3 SUMO2 | SUMOylation of chromatin organization proteins |
| HPA:0470672 | 0.0219529719185 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; melanocytes[>=Medium] |
| HPA:0460181 | 0.0284745500846 | 0.75 | SAE1 SUMO2 SUMO3 | skin 1; cells in granular layer[>=Low] |
| HPA:0470181 | 0.0287284084928 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; cells in granular layer[>=Low] |
| HPA:0461453 | 0.0292462264975 | 0.5 | SUMO3 SUMO2 | skin 1; hair follicles[High] |
| HPA:0470671 | 0.0317556027822 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; melanocytes[>=Low] |
| HPA:0471493 | 0.0323185629783 | 0.5 | SUMO3 SUMO2 | skin 2; vascular mural cells[High] |
| REAC:R-HSA-392499 | 0.0339333915692 | 1.0 | SAE1 SUMO3 TDG SUMO2 | Metabolism of proteins |
| REAC:R-HSA-5696399 | 0.0346321697685 | 0.5 | SUMO3 SUMO2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| HPA:0461493 | 0.0366507731727 | 0.5 | SUMO3 SUMO2 | skin 1; vascular mural cells[High] |
| HPA:0570812 | 0.0387789758455 | 1.0 | SAE1 SUMO3 TDG SUMO2 | testis; spermatogonia cells[>=Medium] |
| HPA:0471461 | 0.0392002139957 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; langerhans cells[>=Low] |
| CORUM:5756 | 0.049938562206 | 0.25 | SAE1 | SUA1-UBA2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SUMO2 | SAE1 | 0.99 | 0.408 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| SUMO2 | SUMO3 | 0.929 | 0.33 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| SAE1 | SUMO3 | 0.928 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM fraction |
| SUMO3 | TDG | 0.894 | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SUMO2 | TDG | 0.333 | 0.157024390244 | bioplex3_WMM WMM_only |
Related Complexes