hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12376.1
Complex Portal: CPX-13949
Confidence: Medium  
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HEATR5B | HEAT repeat-containing protein 5B | 5 | UniProt   NCBI |
| AFTPH | Aftiphilin | 5 | UniProt   NCBI |
| MEA1 | Male-enhanced antigen 1 (MEA-1) | 3 | UniProt   NCBI |
| RALBP1 | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | 5 | UniProt   NCBI |
| AP1G1 | AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) | 5 | UniProt   NCBI |
| RSKR | Ribosomal protein S6 kinase related | 1 | UniProt   NCBI |
| AP2S1 | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) | 5 | UniProt   NCBI |
| REPS1 | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | 5 | UniProt   NCBI |
| KIF13A | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | 5 | UniProt   NCBI |
| AP2A2 | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | 5 | UniProt   NCBI |
| AP1M1 | AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) | 5 | UniProt   NCBI |
| ITSN2 | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | 5 | UniProt   NCBI |
| RUNDC3B | RUN domain-containing protein 3B (Rap2-binding protein 9) (Rap2-interacting protein 9) (RPIP-9) | 4 | UniProt   NCBI |
| AP1S3 | AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin) | 5 | UniProt   NCBI |
| AAGAB | Alpha- and gamma-adaptin-binding protein p34 | 5 | UniProt   NCBI |
| EPS15L1 | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | 5 | UniProt   NCBI |
| SYNRG | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | 5 | UniProt   NCBI |
| AP1S1 | AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) | 5 | UniProt   NCBI |
| REPS2 | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | 5 | UniProt   NCBI |
| AP1B1 | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | 5 | UniProt   NCBI |
| AP2B1 | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | 5 | UniProt   NCBI |
| CCDC32 | Coiled-coil domain-containing protein 32 | 5 | UniProt   NCBI |
| AP1S2 | AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) | 5 | UniProt   NCBI |
| AP1AR | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | 5 | UniProt   NCBI |
| RUNDC3A | RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) | 5 | UniProt   NCBI |
| COMT | Catechol O-methyltransferase (EC 2.1.1.6) | 5 | UniProt   NCBI |
| AP1G2 | AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad) | 5 | UniProt   NCBI |
| AP1M2 | AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) | 5 | UniProt   NCBI |
| NECAP2 | Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) | 4 | UniProt   NCBI |
| SYNJ1 | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | 5 | UniProt   NCBI |
| ITSN1 | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | 5 | UniProt   NCBI |
| NECAP1 | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | 4 | UniProt   NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
|   GO:0030118 | 8.00888985511e-33 | 0.53125 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 SYNJ1 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 EPS15L1 AFTPH | clathrin coat |
|   GO:0030125 | 9.59841735277e-30 | 0.46875 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 AFTPH | clathrin vesicle coat |
|   GO:0030131 | 6.67167443612e-28 | 0.40625 | AP2B1 AP2S1 SYNRG AP2A2 AP1M2 AP1G1 AP1G2 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 AFTPH | clathrin adaptor complex |
|   GO:0048475 | 7.41092147906e-26 | 0.53125 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 SYNJ1 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 EPS15L1 AFTPH | coated membrane |
|   GO:0030117 | 7.41092147906e-26 | 0.53125 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 SYNJ1 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 EPS15L1 AFTPH | membrane coat |
|   GO:0030120 | 2.6474698581e-24 | 0.46875 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 AFTPH | vesicle coat |
|   GO:0030121 | 2.64073278271e-23 | 0.3125 | SYNRG AP1M1 AP1M2 AP1G1 AP1S3 AP1G2 AP1S1 AP1S2 AP1B1 AFTPH | AP-1 adaptor complex |
|   CORUM:144 | 4.69742333751e-23 | 0.28125 | AP1G2 AP1M1 AP1M2 AP1S2 AP1G1 AP1AR AP1S1 AP1B1 AP1S3 | Gamma-BAR-AP1 complex |
|   GO:0030119 | 1.12618183042e-22 | 0.40625 | AP2B1 AP2S1 SYNRG AP2A2 AP1M2 AP1G1 AP1G2 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 AFTPH | AP-type membrane coat adaptor complex |
|   GO:0030130 | 1.73811339363e-21 | 0.3125 | SYNRG AP1M1 AP1M2 AP1G1 AP1S3 AP1G2 AP1S1 AP1S2 AP1B1 AFTPH | clathrin coat of trans-Golgi network vesicle |
|   GO:0030665 | 7.56752018658e-21 | 0.46875 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 AFTPH | clathrin-coated vesicle membrane |
|   GO:0012510 | 2.62892283999e-20 | 0.3125 | SYNRG AP1M1 AP1M2 AP1G1 AP1S3 AP1G2 AP1S1 AP1S2 AP1B1 AFTPH | trans-Golgi network transport vesicle membrane |
|   CORUM:36 | 2.85896927879e-20 | 0.25 | AP1M1 AP1M2 AP1S2 AP1G1 AP1G2 AP1S1 AP1B1 AP1S3 | AP1 adaptor complex |
|   REAC:R-HSA-164938 | 5.56054789065e-20 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
|   REAC:R-HSA-164952 | 1.31907783836e-18 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | The role of Nef in HIV-1 replication and disease pathogenesis |
|   GO:0030136 | 9.30790858837e-18 | 0.46875 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 AFTPH | clathrin-coated vesicle |
|   GO:0030662 | 1.28430298558e-17 | 0.46875 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 AFTPH | coated vesicle membrane |
|   REAC:R-HSA-199991 | 9.17916647453e-17 | 0.59375 | AP2B1 AP2S1 NECAP1 AP1G2 AP1M1 NECAP2 SYNJ1 AP1B1 AP1M2 REPS2 REPS1 AP1G1 AP2A2 AP1S1 ITSN1 AP1S2 ITSN2 EPS15L1 AP1S3 | Membrane Trafficking |
|   GO:0016192 | 2.42042609124e-16 | 0.75 | AP1M2 NECAP1 AP1G2 ITSN2 CCDC32 AP1M1 AP1S1 AP1B1 AP1G1 AP2B1 RALBP1 ITSN1 HEATR5B REPS1 AP1S3 KIF13A REPS2 AP2S1 AP2A2 NECAP2 SYNJ1 EPS15L1 AP1AR AP1S2 | vesicle-mediated transport |
|   REAC:R-HSA-5653656 | 2.54693544491e-16 | 0.59375 | AP2B1 AP2S1 NECAP1 AP1G2 AP1M1 NECAP2 SYNJ1 AP1B1 AP1M2 REPS2 REPS1 AP1G1 AP2A2 AP1S1 ITSN1 AP1S2 ITSN2 EPS15L1 AP1S3 | Vesicle-mediated transport |
|   GO:0030140 | 3.38099280567e-16 | 0.3125 | SYNRG AP1M1 AP1M2 AP1G1 AP1S3 AP1G2 AP1S1 AP1S2 AP1B1 AFTPH | trans-Golgi network transport vesicle |
|   REAC:R-HSA-164940 | 4.31790614667e-15 | 0.21875 | AP1M1 AP1M2 AP1S2 AP1G1 AP1S1 AP1B1 AP1S3 | Nef mediated downregulation of MHC class I complex cell surface expression |
|   GO:0030135 | 7.92379686839e-15 | 0.46875 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 AFTPH | coated vesicle |
|   GO:0030660 | 8.02958252138e-14 | 0.3125 | SYNRG AP1M1 AP1M2 AP1G1 AP1S3 AP1G2 AP1S1 AP1S2 AP1B1 AFTPH | Golgi-associated vesicle membrane |
|   REAC:R-HSA-432720 | 8.28011496032e-13 | 0.25 | AP1M1 AP1M2 AP1S2 AP1G1 AP1G2 AP1S1 AP1B1 AP1S3 | Lysosome Vesicle Biogenesis |
|   REAC:R-HSA-8856828 | 8.42102930703e-13 | 0.34375 | AP2B1 AP2S1 NECAP1 EPS15L1 NECAP2 ITSN2 REPS1 SYNJ1 AP2A2 ITSN1 REPS2 | Clathrin-mediated endocytosis |
|   REAC:R-HSA-8856825 | 1.28935322993e-12 | 0.3125 | AP2B1 AP2S1 NECAP1 EPS15L1 NECAP2 ITSN2 REPS1 AP2A2 ITSN1 REPS2 | Cargo recognition for clathrin-mediated endocytosis |
|   GO:0005905 | 4.38814155235e-12 | 0.28125 | AP2B1 AP2S1 EPS15L1 NECAP2 ITSN1 REPS1 CCDC32 AP2A2 SYNJ1 | clathrin-coated pit |
|   REAC:R-HSA-199992 | 6.0611571222e-12 | 0.28125 | AP1M1 AP1M2 AP1S2 NECAP1 AP1G1 AP1G2 AP1S1 AP1B1 AP1S3 | trans-Golgi Network Vesicle Budding |
|   GO:0005798 | 8.28094571353e-12 | 0.3125 | SYNRG AP1M1 AP1M2 AP1G1 AP1S3 AP1G2 AP1S1 AP1S2 AP1B1 AFTPH | Golgi-associated vesicle |
|   REAC:R-HSA-2132295 | 1.23235024563e-11 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | MHC class II antigen presentation |
|   GO:0035615 | 2.02544019854e-11 | 0.21875 | AP2B1 AP2S1 AP1G2 AP1M1 AP1M2 AP1G1 AP2A2 | clathrin adaptor activity |
|   REAC:R-HSA-162909 | 2.42366845e-11 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | Host Interactions of HIV factors |
|   GO:0140312 | 3.79201196719e-11 | 0.21875 | AP2B1 AP2S1 AP1G2 AP1M1 AP1M2 AP1G1 AP2A2 | cargo adaptor activity |
|   REAC:R-HSA-432722 | 6.0172053965e-11 | 0.25 | AP1M1 AP1M2 AP1S2 NECAP1 AP1G1 AP1S1 AP1B1 AP1S3 | Golgi Associated Vesicle Biogenesis |
|   GO:0030658 | 1.70396476291e-09 | 0.3125 | SYNRG AP1M1 AP1M2 AP1G1 AP1S3 AP1G2 AP1S1 AP1S2 AP1B1 AFTPH | transport vesicle membrane |
|   GO:0012506 | 1.80696364604e-09 | 0.53125 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 SYNJ1 AP1M2 AP1S3 AP1B1 AP1G2 NECAP1 AP1G1 AP1M1 KIF13A AP1S2 AP1S1 AFTPH | vesicle membrane |
|   GO:0006810 | 2.04282576438e-09 | 0.8125 | SYNRG AP1M2 NECAP1 AP1G2 ITSN2 CCDC32 AP1M1 AP1S1 AP1B1 SYNJ1 AP2B1 RALBP1 ITSN1 HEATR5B REPS1 AP1S3 KIF13A REPS2 AFTPH AP2S1 AP2A2 NECAP2 AP1G1 EPS15L1 AP1AR AP1S2 | transport |
|   CORUM:7476 | 2.65042636159e-09 | 0.125 | AP1G2 AP1M1 AP1B1 AP1S1 | AP1B1-AP1G2-AP1M-1AP1S1 complex |
|   REAC:R-HSA-162906 | 7.45458390236e-09 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | HIV Infection |
|   GO:0006897 | 9.59330658684e-09 | 0.4375 | AP2B1 AP2S1 RALBP1 SYNJ1 HEATR5B REPS2 REPS1 CCDC32 AP2A2 AP1S1 ITSN1 NECAP2 ITSN2 EPS15L1 | endocytosis |
|   KEGG:04142 | 1.10192208878e-08 | 0.25 | AP1M1 AP1M2 AP1S2 AP1G1 AP1G2 AP1S1 AP1B1 AP1S3 | Lysosome |
|   GO:0032588 | 1.16979882754e-08 | 0.28125 | AFTPH AP1M1 AP1M2 AP1S2 AP1S3 AP1S1 KIF13A AP1B1 AP1G1 | trans-Golgi network membrane |
|   GO:0051234 | 1.93659898279e-08 | 0.8125 | SYNRG AP1M2 NECAP1 AP1G2 ITSN2 CCDC32 AP1M1 AP1S1 AP1B1 SYNJ1 AP2B1 RALBP1 ITSN1 HEATR5B REPS1 AP1S3 KIF13A REPS2 AFTPH AP2S1 AP2A2 NECAP2 AP1G1 EPS15L1 AP1AR AP1S2 | establishment of localization |
|   GO:0030659 | 2.80559753743e-08 | 0.5 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 AP1M2 AP1S3 AP1B1 AP1G2 NECAP1 AP1G1 AP1M1 KIF13A AP1S2 AP1S1 AFTPH | cytoplasmic vesicle membrane |
|   GO:0098796 | 4.02693706266e-08 | 0.53125 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 SYNJ1 AP1M2 AP1G1 AP1G2 NECAP1 AP1S3 AP1M1 AP1S1 AP1S2 AP1B1 EPS15L1 AFTPH | membrane protein complex |
|   GO:0048753 | 4.76661884616e-08 | 0.21875 | AP1M1 AP1S2 AP1G1 AP1S1 KIF13A AP1B1 AP1S3 | pigment granule organization |
|   GO:0032438 | 4.76661884616e-08 | 0.21875 | AP1M1 AP1S2 AP1G1 AP1S1 KIF13A AP1B1 AP1S3 | melanosome organization |
|   GO:1903232 | 6.10786990182e-08 | 0.1875 | AP1M1 AP1S2 AP1G1 AP1S1 AP1B1 AP1S3 | melanosome assembly |
|   GO:0030133 | 1.50942874803e-07 | 0.34375 | AP1G2 SYNRG AP1M1 AP1M2 AP1G1 AP1S3 AP1AR AP1S1 AP1S2 AP1B1 AFTPH | transport vesicle |
|   GO:0060155 | 1.77721618668e-07 | 0.1875 | AP1M1 AP1S2 AP1G1 AP1S1 AP1B1 AP1S3 | platelet dense granule organization |
|   GO:0097708 | 3.39123500197e-07 | 0.625 | AP2B1 AP2S1 AP1M2 SYNRG AP2A2 NECAP2 HEATR5B AP1S3 AP1B1 AP1G2 NECAP1 AP1S1 AP1G1 AP1M1 KIF13A ITSN1 AP1S2 ITSN2 AP1AR AFTPH | intracellular vesicle |
|   GO:0098657 | 3.70039614782e-07 | 0.4375 | AP2B1 AP2S1 RALBP1 SYNJ1 HEATR5B REPS2 REPS1 CCDC32 AP2A2 AP1S1 ITSN1 NECAP2 ITSN2 EPS15L1 | import into cell |
|   KEGG:05170 | 3.97875829742e-07 | 0.25 | AP1M1 AP1M2 AP1S2 AP1G1 AP1G2 AP1S1 AP1B1 AP1S3 | Human immunodeficiency virus 1 infection |
|   GO:0051179 | 8.1915002e-07 | 0.8125 | SYNRG AP1M2 NECAP1 AP1G2 ITSN2 CCDC32 AP1M1 AP1S1 AP1B1 SYNJ1 AP2B1 RALBP1 ITSN1 HEATR5B REPS1 AP1S3 KIF13A REPS2 AFTPH AP2S1 AP2A2 NECAP2 AP1G1 EPS15L1 AP1AR AP1S2 | localization |
|   GO:0110010 | 9.46202211089e-07 | 0.125 | AP1S1 AP1M2 AP1G1 AP1B1 | basolateral protein secretion |
|   GO:0033059 | 1.1261672884e-06 | 0.21875 | AP1M1 AP1S2 AP1G1 AP1S1 KIF13A AP1B1 AP1S3 | cellular pigmentation |
|   GO:0030132 | 1.42069743999e-06 | 0.15625 | AP2A2 SYNJ1 AP2S1 AP2B1 EPS15L1 | clathrin coat of coated pit |
|   GO:0051649 | 2.26421940277e-06 | 0.5625 | AP2B1 AP2S1 SYNRG AP2A2 SYNJ1 HEATR5B REPS2 AP1G2 REPS1 AP1M2 AP1G1 AP1M1 KIF13A ITSN1 AP1AR ITSN2 EPS15L1 AFTPH | establishment of localization in cell |
|   GO:0043473 | 8.80108473124e-06 | 0.21875 | AP1M1 AP1S2 AP1G1 AP1S1 KIF13A AP1B1 AP1S3 | pigmentation |
|   GO:0033363 | 8.80980354699e-06 | 0.1875 | AP1M1 AP1S2 AP1G1 AP1S1 AP1B1 AP1S3 | secretory granule organization |
|   GO:0072583 | 1.4283114231e-05 | 0.1875 | AP2B1 AP2S1 AP2A2 ITSN1 CCDC32 ITSN2 | clathrin-dependent endocytosis |
|   GO:0051641 | 2.7734883042e-05 | 0.65625 | AP2B1 AP2S1 AP1M2 SYNRG AP2A2 SYNJ1 AP1B1 HEATR5B AP1S3 REPS2 AP1G2 REPS1 AP1S1 AP1G1 AP1M1 KIF13A ITSN1 AP1AR ITSN2 EPS15L1 AFTPH | cellular localization |
|   GO:0005802 | 3.09845601635e-05 | 0.28125 | AFTPH AP1M1 AP1M2 AP1S2 AP1S3 AP1S1 KIF13A AP1B1 AP1G1 | trans-Golgi network |
|   GO:0031410 | 4.3644661201e-05 | 0.5625 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 HEATR5B AP1S3 AP1B1 AP1G2 NECAP1 AP1M2 AP1G1 AP1M1 KIF13A AP1S2 AP1S1 AP1AR AFTPH | cytoplasmic vesicle |
|   REAC:R-HSA-9824446 | 4.56533677878e-05 | 0.34375 | AP2B1 AP2S1 COMT AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | Viral Infection Pathways |
|   GO:0098852 | 5.54639611253e-05 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | lytic vacuole membrane |
|   GO:0005765 | 5.54639611253e-05 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | lysosomal membrane |
|   WP:WP437 | 7.95683015328e-05 | 0.1875 | AP2B1 AP2S1 RALBP1 SYNJ1 EPS15L1 REPS2 | EGF EGFR signaling pathway |
|   REAC:R-HSA-182218 | 0.000100529188703 | 0.09375 | AP2A2 AP2S1 AP2B1 | Nef Mediated CD8 Down-regulation |
|   GO:0005774 | 0.000116422902916 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | vacuolar membrane |
|   GO:0098791 | 0.000128591878688 | 0.28125 | AFTPH AP1M1 AP1M2 AP1S2 AP1S3 AP1S1 KIF13A AP1B1 AP1G1 | Golgi apparatus subcompartment |
|   GO:0031982 | 0.000223402722797 | 0.6875 | SYNRG AP1M2 NECAP1 AP1G2 COMT AP1B1 AP1G1 AP2B1 AP1M1 ITSN1 HEATR5B AP1S3 AP1S1 KIF13A ITSN2 AFTPH AP2S1 AP2A2 NECAP2 SYNJ1 AP1AR AP1S2 | vesicle |
|   REAC:R-HSA-167590 | 0.000240552469681 | 0.09375 | AP2A2 AP2S1 AP2B1 | Nef Mediated CD4 Down-regulation |
|   REAC:R-HSA-1280218 | 0.000275932217442 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | Adaptive Immune System |
|   REAC:R-HSA-5663205 | 0.000358800487955 | 0.34375 | AP2B1 AP2S1 COMT AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | Infectious disease |
|   GO:0098588 | 0.000502052837236 | 0.5 | AP2B1 AP2S1 SYNRG AP2A2 NECAP2 AP1M2 AP1S3 AP1B1 AP1G2 NECAP1 AP1G1 AP1M1 KIF13A AP1S2 AP1S1 AFTPH | bounding membrane of organelle |
|   REAC:R-HSA-177504 | 0.000627210086649 | 0.09375 | AP2A2 AP2S1 AP2B1 | Retrograde neurotrophin signalling |
|   REAC:R-HSA-5140745 | 0.00081415991778 | 0.09375 | AP2A2 AP2S1 AP2B1 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
|   REAC:R-HSA-5099900 | 0.00129140312103 | 0.09375 | AP2A2 AP2S1 AP2B1 | WNT5A-dependent internalization of FZD4 |
|   REAC:R-HSA-8866427 | 0.00158705464743 | 0.09375 | AP2A2 AP2S1 AP2B1 | VLDLR internalisation and degradation |
|   GO:0140238 | 0.00208288951809 | 0.15625 | AP2B1 ITSN1 SYNJ1 AP2S1 ITSN2 | presynaptic endocytosis |
|   GO:0048488 | 0.00208288951809 | 0.15625 | AP2B1 ITSN1 SYNJ1 AP2S1 ITSN2 | synaptic vesicle endocytosis |
|   REAC:R-HSA-8964038 | 0.00230569012365 | 0.09375 | AP2A2 AP2S1 AP2B1 | LDL clearance |
|   WP:WP4159 | 0.00246117855389 | 0.09375 | AP2A2 AP2S1 AP2B1 | GABA receptor signaling |
|   GO:0036465 | 0.00531722111361 | 0.15625 | AP2B1 ITSN1 SYNJ1 AP2S1 ITSN2 | synaptic vesicle recycling |
|   GO:0099003 | 0.005486489683 | 0.1875 | AP2B1 AP2S1 AP2A2 ITSN1 SYNJ1 ITSN2 | vesicle-mediated transport in synapse |
|   GO:0016050 | 0.0059571967726 | 0.25 | AP1M1 SYNJ1 AP1S2 AP1G1 AP1S1 KIF13A AP1B1 AP1S3 | vesicle organization |
|   GO:0006898 | 0.00718317189856 | 0.21875 | AP2B1 AP2S1 AP2A2 ITSN1 CCDC32 AP1S1 ITSN2 | receptor-mediated endocytosis |
|   GO:0005768 | 0.00820878418643 | 0.34375 | AP2B1 AP2S1 AP1M1 AP1B1 AP1G1 AP2A2 KIF13A AP1S2 AP1S1 AP1AR AP1S3 | endosome |
|   GO:0046907 | 0.0084996601459 | 0.40625 | AP1G2 AFTPH AP1M1 HEATR5B REPS2 REPS1 AP1G1 EPS15L1 KIF13A ITSN1 ITSN2 AP1AR SYNRG | intracellular transport |
|   REAC:R-HSA-2682334 | 0.00889912036796 | 0.125 | AP2A2 ITSN1 AP2S1 AP2B1 | EPH-Ephrin signaling |
|   KEGG:04961 | 0.00898339354695 | 0.09375 | AP2A2 AP2S1 AP2B1 | Endocrine and other factor-regulated calcium reabsorption |
|   REAC:R-HSA-9679191 | 0.0102547156638 | 0.125 | COMT AP2A2 AP2S1 AP2B1 | Potential therapeutics for SARS |
|   GO:0005764 | 0.0117298015665 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | lysosome |
|   GO:0000323 | 0.0117298015665 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | lytic vacuole |
|   REAC:R-HSA-8964043 | 0.0137260080758 | 0.09375 | AP2A2 AP2S1 AP2B1 | Plasma lipoprotein clearance |
|   GO:0012505 | 0.0141757857017 | 0.65625 | AP2B1 AP1G2 AP2S1 SYNRG AP2A2 NECAP2 SYNJ1 AP1M2 AP1S3 AP1B1 CCDC32 REPS1 AP1G1 AP1M1 KIF13A ITSN1 AP1S2 AP1AR AP1S1 EPS15L1 AFTPH | endomembrane system |
|   WP:WP2267 | 0.0145884137954 | 0.09375 | AP2A2 AP2S1 AP2B1 | Synaptic vesicle pathway |
|   GO:0098884 | 0.016587316136 | 0.09375 | AP2A2 AP2S1 AP2B1 | postsynaptic neurotransmitter receptor internalization |
|   GO:0140239 | 0.016587316136 | 0.09375 | AP2A2 AP2S1 AP2B1 | postsynaptic endocytosis |
|   KEGG:04721 | 0.0185957089956 | 0.09375 | AP2A2 AP2S1 AP2B1 | Synaptic vesicle cycle |
|   GO:0030128 | 0.0265002084656 | 0.09375 | AP2A2 AP2S1 AP2B1 | clathrin coat of endocytic vesicle |
|   GO:0030122 | 0.0265002084656 | 0.09375 | AP2A2 AP2S1 AP2B1 | AP-2 adaptor complex |
|   GO:0005773 | 0.0285516958769 | 0.3125 | AP2B1 AP2S1 AP2A2 AP1M2 AP1S2 AP1G1 AP1M1 AP1S1 AP1B1 AP1S3 | vacuole |
|   REAC:R-HSA-3928665 | 0.0360023458287 | 0.09375 | AP2A2 AP2S1 AP2B1 | EPH-ephrin mediated repulsion of cells |
|   REAC:R-HSA-437239 | 0.0411426249887 | 0.09375 | AP2A2 AP2S1 AP2B1 | Recycling pathway of L1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
|  RALBP1 |  REPS1 | 1.0 | 0.374           |
structurally_consistent (dimer)        
|
|  AP1B1 |  AP1S2 | 1.0 | 0.24           |
mutually_exclusive (O43747)        
|
|  AP2B1 |  AP1S2 | 1.0 | 0.142           |          |
|  AP1M1 |  AP1B1 | 1.0 | 0.434           |
structurally_consistent (dimer)        
|
|  AP2A2 |  AP2B1 | 1.0 | 0.336153846154           |          |
|  AP1S2 |  AP1G2 | 1.0 | 0.104           |
structurally_consistent (dimer)        
|
|  AP1B1 |  AP1G1 | 1.0 | 0.682           |
mixed_interface        
|
|  RALBP1 |  REPS2 | 1.0 | 0.28           |
structurally_consistent (dimer)        
|
|  AP2B1 |  AP2S1 | 1.0 | 0.7           |
structurally_consistent (O95782)        
|
|  AP2A2 |  AP2S1 | 1.0 | 0.282           |
structurally_consistent (dimer)        
|
|  CCDC32 |  AP2S1 | 1.0 | 0.13           |
structurally_consistent (dimer)        
|
|  AP1M2 |  AP1G1 | 1.0 | 0.068           |
mixed_interface        
|
|  AP1M1 |  AP1S2 | 1.0 | 0.28           |
mutually_exclusive (O43747)        
structurally_consistent (dimer)         |
|  AP1S2 |  AP1G1 | 1.0 | 0.226           |
structurally_consistent (dimer)        
|
|  AP1M1 |  AP1G1 | 1.0 | 0.538           |
structurally_consistent (Q10567)        
structurally_consistent (dimer)         |
|  AP2B1 |  NECAP2 | 1.0 | 0.09           |
mutually_exclusive (Q96CW1)        
|
|  AP1S2 |  HEATR5B | 1.0 | 0.114           |          |
|  AP2S1 |  AP1B1 | 1.0 | 0.258           |          |
|  AP1B1 |  AP1M2 | 1.0 | 0.218           |
structurally_consistent (Q9BXS5)        
structurally_consistent (dimer)         |
|  NECAP2 |  AP1B1 | 0.999 | 0.14           |
mutually_exclusive (Q96CW1)        
|
|  AP2B1 |  AP1B1 | 0.999 | 0.718           |
mutually_exclusive (Q9Y6Q5)        
|
|  RUNDC3A |  RUNDC3B | 0.999 |            |          |
|  EPS15L1 |  AP2S1 | 0.999 | 0.222           |          |
|  AP1G2 |  AP1M2 | 0.999 | 0.072           |
structurally_consistent (dimer)        
|
|  AP2A2 |  NECAP2 | 0.999 | 0.138416666667           |          |
|  ITSN1 |  AP2S1 | 0.999 |            |          |
|  CCDC32 |  AAGAB | 0.999 | 0.11           |
mutually_exclusive (P53680)        
|
|  AP2B1 |  ITSN1 | 0.999 |            |          |
|  AP1S2 |  AP1AR | 0.999 | 0.052           |          |
|  AP1S2 |  AFTPH | 0.999 | 0.072           |          |
|  AP2B1 |  AP1M2 | 0.999 | 0.026           |
structurally_consistent (dimer)        
|
|  NECAP2 |  AP2S1 | 0.999 | 0.076           |
structurally_consistent (dimer)        
|
|  AP2A2 |  AAGAB | 0.999 | 0.1305           |          |
|  AP1S1 |  AP1M2 | 0.999 | 0.072           |
mutually_exclusive (O43747)        
structurally_consistent (dimer)         |
|  AP1B1 |  AP1S3 | 0.999 | 0.174           |          |
|  AP2A2 |  EPS15L1 | 0.999 | 0.313555555556           |          |
|  AP2B1 |  EPS15L1 | 0.999 | 0.446           |          |
|  AP1S2 |  SYNRG | 0.999 | 0.152           |          |
|  AP1B1 |  MEA1 | 0.999 | 0.084           |          |
|  SYNRG |  AFTPH | 0.999 | 0.126           |          |
|  HEATR5B |  AP1S3 | 0.999 | 0.032           |          |
|  AP1S3 |  AP1G1 | 0.999 | 0.188           |
structurally_consistent (dimer)        
|
|  AP1S2 |  AP1M2 | 0.999 | 0.174           |
mutually_exclusive (O75843)        
|
|  AP1M2 |  AP1S3 | 0.999 | 0.024           |          |
|  AP2S1 |  REPS1 | 0.999 | 0.044           |          |
|  AAGAB |  AP1S2 | 0.998 | 0.072           |
mutually_exclusive (O75843)        
|
|  AAGAB |  AP2S1 | 0.998 | 0.058           |
structurally_consistent (dimer)        
|
|  AP2A2 |  AP1B1 | 0.998 | 0.266           |
mutually_exclusive (O43747)        
|
|  AP1M1 |  AP1S3 | 0.998 | 0.082           |
mutually_exclusive (O43747)        
|
|  AP2B1 |  AP1M1 | 0.998 | 0.39           |
structurally_consistent (dimer)        
|
|  EPS15L1 |  ITSN1 | 0.998 |            |          |
|  AFTPH |  AP1S3 | 0.998 | 0.064           |          |
|  AP1M2 |  MEA1 | 0.998 | 0.068           |
mutually_exclusive (Q9BXS5)        
structurally_consistent (dimer)         |
|  REPS2 |  REPS1 | 0.998 | 0.144           |
mutually_exclusive (Q15311)        
|
|  AP2A2 |  CCDC32 | 0.998 | 0.13           |          |
|  AP2B1 |  AP1G1 | 0.998 | 0.532           |
mutually_exclusive (Q9Y6Q5)        
|
|  AP2B1 |  MEA1 | 0.998 | 0.086           |          |
|  KIF13A |  AP1S3 | 0.997 |            |          |
|  AP1M1 |  MEA1 | 0.997 | 0.084           |
mutually_exclusive (Q9Y6Q5)        
structurally_consistent (dimer)         |
|  AP2B1 |  AP1S3 | 0.997 | 0.16           |          |
|  AP2B1 |  REPS1 | 0.997 | 0.152           |          |
|  SYNRG |  AP1S3 | 0.997 | 0.078           |          |
|  ITSN2 |  EPS15L1 | 0.997 | 0.118           |          |
|  EPS15L1 |  AP1B1 | 0.997 | 0.38           |          |
|  ITSN1 |  AP1B1 | 0.996 |            |          |
|  AAGAB |  AP1S3 | 0.996 | 0.046           |
mutually_exclusive (O75843)        
|
|  AP1B1 |  AP1G2 | 0.996 | 0.052           |
mutually_exclusive (Q9Y6Q5)        
|
|  NECAP2 |  NECAP1 | 0.996 | 0.076           |          |
|  HEATR5B |  AFTPH | 0.995 | 0.326           |          |
|  EPS15L1 |  RUNDC3A | 0.995 | 0.09           |
structurally_consistent (dimer)        
|
|  AP1AR |  AP1S3 | 0.994 | 0.096           |          |
|  HEATR5B |  AP1G1 | 0.994 | 0.048           |          |
|  AP2S1 |  RALBP1 | 0.993 | 0.204           |          |
|  AP1B1 |  HEATR5B | 0.993 | 0.224           |          |
|  AP2A2 |  RUNDC3A | 0.993 | 0.142           |          |
|  AP1G2 |  AP1G1 | 0.993 | 0.096           |
mutually_exclusive (Q9Y6Q5)        
structurally_consistent (dimer)         |
|  AP2B1 |  AP1G2 | 0.992 | 0.084           |
mutually_exclusive (Q9Y6Q5)        
|
|  AP1S2 |  MEA1 | 0.992 | 0.038           |          |
|  AP1G2 |  AP1S3 | 0.991 | 0.046           |
structurally_consistent (dimer)        
|
|  RALBP1 |  RUNDC3A | 0.991 | 0.078           |          |
|  SYNRG |  HEATR5B | 0.991 | 0.125           |          |
|  HEATR5B |  AP1G2 | 0.99 | 0.064           |          |
|  AP1S2 |  AP1S3 | 0.99 | 0.062           |          |
|  AP2B1 |  NECAP1 | 0.989 | 0.108           |          |
|  AFTPH |  AP1G1 | 0.989 | 0.09           |          |
|  AP2B1 |  AP1S1 | 0.989 | 0.186           |          |
|  NECAP1 |  REPS1 | 0.988 | 0.09           |          |
|  AAGAB |  AP1G1 | 0.988 | 0.082           |          |
|  AP1S1 |  SYNJ1 | 0.987 | 0.072           |          |
|  AP1M1 |  AP1G2 | 0.987 | 0.016           |
mutually_exclusive (P56377)        
|
|  KIF13A |  AP1M2 | 0.986 |            |          |
|  AP1M1 |  AFTPH | 0.986 | 0.154           |          |
|  AP1S1 |  AP1B1 | 0.985 | 0.112           |
mutually_exclusive (O43747)        
|
|  AP1M1 |  SYNRG | 0.985 | 0.182           |          |
|  EPS15L1 |  RALBP1 | 0.985 | 0.126           |          |
|  AP2B1 |  RALBP1 | 0.985 | 0.124           |
mutually_exclusive (Q96CW1)        
|
|  ITSN2 |  ITSN1 | 0.985 |            |          |
|  SYNRG |  AP1G1 | 0.985 | 0.23           |          |
|  AP1B1 |  NECAP1 | 0.984 | 0.278           |
structurally_consistent (dimer)        
|
|  AP1B1 |  AFTPH | 0.984 | 0.184           |          |
|  MEA1 |  AP1G1 | 0.984 | 0.076           |          |
|  AP1B1 |  RALBP1 | 0.983 | 0.16           |
mutually_exclusive (Q96CW1)        
|
|  ITSN2 |  AP2S1 | 0.982 | 0.084           |          |
|  AP2B1 |  RUNDC3A | 0.981 | 0.152           |          |
|  AP2B1 |  AAGAB | 0.981 | 0.13           |          |
|  AP1S1 |  AP1M1 | 0.98 | 0.248           |          |
|  AP1G2 |  AFTPH | 0.979 | 0.06           |          |
|  AP2A2 |  RALBP1 | 0.978 | 0.168           |          |
|  AP1S1 |  AP1S3 | 0.978 | 0.2           |          |
|  MEA1 |  AP1S3 | 0.978 | 0.07           |          |
|  AP2A2 |  ITSN1 | 0.976 |            |          |
|  ITSN1 |  RALBP1 | 0.975 |            |          |
|  AP1S1 |  MEA1 | 0.975 | 0.03           |          |
|  NECAP1 |  AP1G1 | 0.974 | 0.126           |
mutually_exclusive (P53680)        
|
|  REPS1 |  AP1G1 | 0.974 | 0.086           |          |
|  AP2S1 |  AP1S3 | 0.974 | 0.098           |
mutually_exclusive (O43747)        
|
|  AP2B1 |  CCDC32 | 0.974 | 0.06           |          |
|  ITSN2 |  AP1B1 | 0.973 | 0.126           |          |
|  SYNJ1 |  NECAP1 | 0.972 | 0.202           |          |
|  AP1B1 |  SYNRG | 0.972 | 0.179           |          |
|  AP1S1 |  AP1G1 | 0.971 | 0.402666666667           |
structurally_consistent (dimer)        
|
|  AP2A2 |  AP1S3 | 0.971 | 0.142           |
structurally_consistent (O43747)        
|
|  AP2S1 |  RUNDC3A | 0.97 | 0.054           |          |
|  AP1S1 |  NECAP1 | 0.968 | 0.048           |
structurally_consistent (Q9Y6Q5)        
|
|  AP1S1 |  AP1S2 | 0.966 | 0.056           |
mutually_exclusive (O43747)        
|
|  AP1M1 |  NECAP1 | 0.966 | 0.22           |
structurally_consistent (dimer)        
|
|  AP1B1 |  REPS1 | 0.965 | 0.114           |          |
|  AP2A2 |  ITSN2 | 0.963 | 0.36           |          |
|  SYNJ1 |  RALBP1 | 0.963 | 0.136           |          |
|  AP1B1 |  SYNJ1 | 0.961 | 0.194           |          |
|  AP2S1 |  AP1S2 | 0.961 | 0.176           |          |
|  SYNJ1 |  AP1G1 | 0.958 | 0.094           |          |
|  AP1S1 |  RALBP1 | 0.958 | 0.062           |          |
|  AP1S1 |  REPS1 | 0.958 | 0.052           |          |
|  ITSN2 |  AP2B1 | 0.957 | 0.082           |          |
|  AP2A2 |  AP1S2 | 0.955 | 0.166           |          |
|  RALBP1 |  AP1G1 | 0.953 | 0.118           |          |
|  HEATR5B |  AP1M2 | 0.953 | 0.086           |          |
|  SYNJ1 |  REPS1 | 0.953 | 0.188           |          |
|  AFTPH |  AP1M2 | 0.951 | 0.044           |          |
|  SYNRG |  AP1M2 | 0.951 |            |          |
|  KIF13A |  AP1G1 | 0.95 |            |          |
|  ITSN1 |  MEA1 | 0.949 |            |          |
|  AP1S1 |  AP1G2 | 0.949 | 0.028           |
structurally_consistent (dimer)        
|
|  AAGAB |  AP1S1 | 0.948 | 0.038           |
mutually_exclusive (O75843)        
structurally_consistent (dimer)         |
|  SYNRG |  AP1G2 | 0.947 | 0.222           |          |
|  AP1G2 |  MEA1 | 0.946 | 0.014           |          |
|  ITSN1 |  AP1S3 | 0.946 |            |          |
|  AP1M1 |  HEATR5B | 0.943 | 0.14           |          |
|  AP1B1 |  AP1AR | 0.942 | 0.094           |          |
|  AP2S1 |  SYNJ1 | 0.942 | 0.086           |          |
|  RUNDC3A |  REPS1 | 0.935 | 0.076           |
structurally_consistent (dimer)        
|
|  AP1AR |  SYNRG | 0.933 | 0.088           |          |
|  EPS15L1 |  MEA1 | 0.933 | 0.138           |          |
|  AP1S1 |  COMT | 0.932 | 0.08           |          |
|  AP2A2 |  AP1S1 | 0.929 | 0.158235294118           |
structurally_consistent (O43747)        
structurally_consistent (dimer)         |
|  AP2A2 |  REPS1 | 0.928 | 0.288079365079           |          |
|  NECAP2 |  EPS15L1 | 0.927 | 0.096           |          |
|  EPS15L1 |  REPS1 | 0.927 | 0.112           |
mutually_exclusive (Q59EK9)        
|
|  AP2B1 |  SYNJ1 | 0.924 | 0.198           |          |
|  NECAP1 |  RALBP1 | 0.924 | 0.142           |
mutually_exclusive (Q96CW1)        
|
|  ITSN1 |  REPS1 | 0.922 |            |          |
|  AP1AR |  AFTPH | 0.918 | 0.086           |          |
|  AP1M1 |  SYNJ1 | 0.917 | 0.162           |          |
|  AP1AR |  AP1G1 | 0.916 | 0.112           |
structurally_consistent (Q9BXS5)        
structurally_consistent (dimer)         |
|  NECAP2 |  ITSN1 | 0.913 |            |          |
|  AP1M1 |  AP1M2 | 0.912 | 0.056           |
structurally_consistent (dimer)        
|
|  AP2S1 |  MEA1 | 0.91 | 0.044           |          |
|  AAGAB |  AP1B1 | 0.907 | 0.066           |          |
|  AP1AR |  HEATR5B | 0.905 | 0.05           |          |
|  AP1B1 |  KIF13A | 0.899 |            |          |
|  AP1M1 |  RALBP1 | 0.898 | 0.132           |          |
|  NECAP2 |  AP1G1 | 0.894 | 0.108666666667           |          |
|  AP1M1 |  AP1AR | 0.893 | 0.062           |
structurally_consistent (dimer)        
|
|  AP1AR |  AP1G2 | 0.893 | 0.06           |
structurally_consistent (O43747)        
|
|  NECAP1 |  SYNRG | 0.889 | 0.104           |          |
|  AP1M1 |  COMT | 0.881 | 0.156           |
structurally_consistent (dimer)        
|
|  AP1S1 |  KIF13A | 0.879 |            |          |
|  ITSN1 |  AP1G1 | 0.878 |            |          |
|  AP2S1 |  AP1S1 | 0.876 | 0.1           |          |
|  AP1S1 |  SYNRG | 0.872 | 0.054           |          |
|  NECAP2 |  REPS1 | 0.847 | 0.04           |          |
|  NECAP2 |  RALBP1 | 0.846 | 0.138           |
mutually_exclusive (Q96CW1)        
|
|  CCDC32 |  AP1B1 | 0.845 | 0.092           |          |
|  AP1S2 |  KIF13A | 0.839 |            |          |
|  EPS15L1 |  AP1G1 | 0.838 | 0.274           |          |
|  AP1S2 |  COMT | 0.832 | 0.092           |
structurally_consistent (Q9BXS5)        
|
|  AP2S1 |  REPS2 | 0.824 | 0.12           |
structurally_consistent (dimer)        
|
|  AFTPH |  MEA1 | 0.822 | 0.078           |          |
|  AP1M1 |  REPS1 | 0.822 | 0.07           |          |
|  NECAP1 |  AP1M2 | 0.819 | 0.04           |
mutually_exclusive (Q9BXS5)        
structurally_consistent (dimer)         |
|  SYNJ1 |  SYNRG | 0.814 | 0.094           |          |
|  RALBP1 |  MEA1 | 0.81 | 0.014           |
mutually_exclusive (Q96CW1)        
|
|  NECAP1 |  AP1S3 | 0.806 | 0.072           |          |
|  AP1M1 |  KIF13A | 0.797 |            |          |
|  ITSN1 |  AP1S2 | 0.796 |            |          |
|  SYNJ1 |  AP1S3 | 0.795 | 0.08           |          |
|  KIF13A |  HEATR5B | 0.795 |            |          |
|  KIF13A |  AFTPH | 0.795 |            |          |
|  SYNRG |  KIF13A | 0.795 |            |          |
|  EPS15L1 |  RUNDC3B | 0.793 |            |          |
|  AP2B1 |  AFTPH | 0.787 | 0.226           |          |
|  NECAP2 |  MEA1 | 0.783 | 0.03           |
mutually_exclusive (Q96CW1)        
|
|  KIF13A |  AP1G2 | 0.783 |            |          |
|  AP2A2 |  MEA1 | 0.781 | 0.085           |          |
|  AP2A2 |  SYNJ1 | 0.778 | 0.118           |          |
|  HEATR5B |  MEA1 | 0.777 | 0.044           |          |
|  AP1B1 |  RUNDC3A | 0.766 | 0.06           |          |
|  AP2B1 |  HEATR5B | 0.762 | 0.166           |          |
|  ITSN1 |  AP1S1 | 0.732 |            |          |
|  NECAP2 |  RUNDC3A | 0.729 | 0.07           |          |
|  KIF13A |  MEA1 | 0.726 |            |          |
|  AP2B1 |  AP1AR | 0.72 | 0.188           |          |
|  AP1G1 |  COMT | 0.716 | 0.136           |
structurally_consistent (Q9BXS5)        
|
|  AAGAB |  AP1G2 | 0.71 | 0.054           |
structurally_consistent (dimer)        
|
|  NECAP1 |  AP1S2 | 0.705 | 0.124           |          |
|  NECAP1 |  AP1G2 | 0.699 | 0.056           |          |
|  SYNRG |  REPS1 | 0.688 | 0.124           |          |
|  AP2B1 |  SYNRG | 0.686 | 0.220090909091           |          |
|  NECAP1 |  MEA1 | 0.661 | 0.042           |          |
|  AP1G2 |  COMT | 0.658 | 0.03           |          |
|  AAGAB |  ITSN1 | 0.656 |            |          |
|  AP2S1 |  AP1G1 | 0.65 | 0.158           |
structurally_consistent (dimer)        
|
|  AAGAB |  AP1AR | 0.625 | 0.126           |          |
|  AP1S1 |  AFTPH | 0.623 | 0.046           |          |
|  CCDC32 |  ITSN1 | 0.617 |            |          |
|  AP2S1 |  NECAP1 | 0.615 | 0.082           |
structurally_consistent (dimer)        
|
|  AP2B1 |  KIF13A | 0.608 |            |          |
|  MEA1 |  REPS1 | 0.601 | 0.05           |          |
|  AAGAB |  HEATR5B | 0.598 | 0.052           |          |
|  AP2B1 |  RUNDC3B | 0.596 |            |          |
|  AP1B1 |  COMT | 0.592 | 0.16           |
structurally_consistent (Q9BXS5)        
|
|  SYNRG |  MEA1 | 0.578 | 0.034           |          |
|  EPS15L1 |  AP1S2 | 0.574 | 0.072           |          |
|  AAGAB |  AFTPH | 0.565 | 0.078           |          |
|  RALBP1 |  RUNDC3B | 0.558 |            |          |
|  AAGAB |  SYNRG | 0.554 | 0.104           |          |
|  AP2A2 |  AP1G1 | 0.548 | 0.0923333333333           |
structurally_consistent (dimer)        
|
|  ITSN2 |  AP1S3 | 0.522 | 0.068           |          |
|  AP2A2 |  RUNDC3B | 0.517 |            |          |
|  AP2S1 |  RUNDC3B | 0.517 |            |          |
|  NECAP2 |  RUNDC3B | 0.502 |            |          |
|  NECAP1 |  KIF13A | 0.496 |            |          |
|  AP1AR |  KIF13A | 0.49 |            |          |
|  AP1S2 |  RALBP1 | 0.48 | 0.118           |          |
|  CCDC32 |  EPS15L1 | 0.475 | 0.202           |          |
|  AP2A2 |  NECAP1 | 0.475 | 0.16           |
mutually_exclusive (P53680)        
|
|  ITSN2 |  AP1S1 | 0.471 | 0.074           |          |
|  RALBP1 |  AP1S3 | 0.467 | 0.108           |          |
|  ITSN2 |  AP1S2 | 0.467 | 0.082           |          |
|  SYNJ1 |  MEA1 | 0.463 | 0.032           |          |
|  EPS15L1 |  NECAP1 | 0.43 | 0.158           |          |
|  NECAP2 |  AP1M1 | 0.428 | 0.108           |          |
|  ITSN1 |  SYNJ1 | 0.416 |            |          |
|  AAGAB |  EPS15L1 | 0.415 | 0.066           |          |
|  NECAP1 |  AFTPH | 0.415 | 0.116           |          |
|  AP1AR |  AP1M2 | 0.402 | 0.05           |
mutually_exclusive (Q9BXS5)        
|
|  AP2A2 |  AP1G2 | 0.374 | 0.108           |          |
|  SYNJ1 |  AP1AR | 0.364 | 0.072           |          |
|  ITSN1 |  NECAP1 | 0.36 |            |          |
|  AP1S3 |  COMT | 0.356 | 0.106           |          |
|  ITSN2 |  NECAP1 | 0.353 | 0.092           |          |
|  NECAP2 |  AP1S1 | 0.353 | 0.048           |          |
|  AP1S1 |  HEATR5B | 0.34 | 0.04           |          |
|  EPS15L1 |  AP1S3 | 0.34 | 0.12           |          |
|  EPS15L1 |  AP1S1 | 0.322 | 0.068           |          |
|  AP2A2 |  AP1M2 | 0.317 | 0.114           |          |
|  NECAP2 |  AP1S2 | 0.315 | 0.05           |          |
|  RUNDC3B |  REPS1 | 0.303 |            |          |
|  NECAP1 |  HEATR5B | 0.302 | 0.062           |          |
|  NECAP2 |  AP1S3 | 0.3 | 0.054           |          |
|  ITSN2 |  AP1G1 | 0.3 | 0.096           |          |
|  ITSN1 |  AP1G2 | 0.293 |            |          |
|  SYNJ1 |  AP1S2 | 0.287 | 0.098           |          |
|  AP1S2 |  REPS1 | 0.285 | 0.048           |          |
|  RALBP1 |  SYNRG | 0.281 | 0.102           |          |
|  AAGAB |  AP1M1 | 0.277 | 0.114           |          |
|  RALBP1 |  AP1M2 | 0.277 | 0.056           |          |
|  AP2S1 |  AP1G2 | 0.266 | 0.04           |          |
|  AP1S3 |  REPS1 | 0.247 | 0.072           |          |
|  AAGAB |  RALBP1 | 0.24 | 0.034           |          |
|  ITSN2 |  MEA1 | 0.239 | 0.04           |          |
|  ITSN2 |  RALBP1 | 0.231 | 0.07           |          |
|  NECAP2 |  AP1M2 | 0.228 | 0.014           |          |
|  CCDC32 |  REPS1 | 0.209 | 0.094           |          |
|  EPS15L1 |  AP1G2 | 0.206 | 0.04           |          |
|  RALBP1 |  KIF13A | 0.184 |            |          |
|  AAGAB |  NECAP2 | 0.18 | 0.03           |
mutually_exclusive (P53680)        
|
|  AP1AR |  MEA1 | 0.178 | 0.062           |          |
|  KIF13A |  REPS1 | 0.173 |            |          |
|  CCDC32 |  NECAP2 | 0.172 | 0.086           |
mutually_exclusive (P53680)        
|
|  CCDC32 |  AP1S3 | 0.172 | 0.064           |          |
|  AP1B1 |  RUNDC3B | 0.167 |            |          |
|  CCDC32 |  RALBP1 | 0.164 | 0.128           |          |
|  CCDC32 |  AP1G1 | 0.164 | 0.036           |          |
|  RALBP1 |  AP1G2 | 0.161 | 0.04           |          |
|  SYNJ1 |  AP1M2 | 0.159 | 0.068           |          |
|  AP2S1 |  AP1M2 | 0.153 | 0.062           |          |
|  ITSN1 |  RUNDC3A | 0.152 |            |          |
|  SYNJ1 |  KIF13A | 0.144 |            |          |
|  ITSN2 |  KIF13A | 0.144 |            |          |
|  CCDC32 |  AP1S2 | 0.143 | 0.1           |          |
|  AP2A2 |  AP1M1 | 0.139 | 0.274           |          |
|  ITSN2 |  SYNJ1 | 0.131 | 0.112           |          |
|  AP1AR |  RALBP1 | 0.13 | 0.22           |          |
|  AP2A2 |  AP1AR | 0.13 | 0.118           |          |
|  AP2S1 |  AP1AR | 0.13 | 0.108           |          |
|  AFTPH |  REPS1 | 0.129 | 0.11           |          |
|  ITSN1 |  AP1M1 | 0.123 |            |          |
|  AP2S1 |  AP1M1 | 0.117 | 0.34           |          |
|  EPS15L1 |  SYNJ1 | 0.114 | 0.16           |          |
|  NECAP1 |  AP1AR | 0.113 | 0.106           |          |
|  AAGAB |  AP1M2 | 0.107 | 0.1           |          |
|  MEA1 |  COMT | 0.105 | 0.036           |
mutually_exclusive (Q9BXS5)        
|
|  NECAP2 |  SYNJ1 | 0.105 | 0.134           |          |
|  AAGAB |  NECAP1 | 0.102 | 0.118           |
mutually_exclusive (P53680)        
|
|  AAGAB |  REPS1 | 0.096 | 0.044           |          |
|  NECAP2 |  AP1G2 | 0.093 | 0.034           |          |
|  EPS15L1 |  AP1M1 | 0.093 | 0.21           |          |
|  ITSN2 |  AFTPH | 0.093 | 0.064           |          |
|  ITSN1 |  AFTPH | 0.087 |            |          |
|  AP2A2 |  COMT | 0.087 | 0.27           |          |
|  AP1M2 |  REPS1 | 0.083 | 0.066           |          |
|  AP1AR |  REPS1 | 0.082 | 0.072           |          |
|  REPS2 |  AP1G1 | 0.08 | 0.094           |
mutually_exclusive (P53680)        
|
|  AP1S2 |  REPS2 | 0.08 | 0.086           |          |
|  AAGAB |  KIF13A | 0.076 |            |          |
|  NECAP2 |  KIF13A | 0.076 |            |          |
|  ITSN1 |  AP1M2 | 0.076 |            |          |
|  SYNJ1 |  AFTPH | 0.075 | 0.112           |          |
|  AP1G2 |  REPS1 | 0.075 | 0.044           |          |
|  RALBP1 |  AFTPH | 0.074 | 0.224           |          |
|  REPS2 |  KIF13A | 0.073 |            |          |
|  EPS15L1 |  HEATR5B | 0.073 | 0.188           |          |
|  AFTPH |  COMT | 0.073 | 0.036           |          |
|  ITSN2 |  AP1G2 | 0.073 | 0.044           |          |
|  AAGAB |  MEA1 | 0.07 | 0.116           |          |
|  REPS2 |  AP1S3 | 0.07 | 0.096           |          |
|  NECAP1 |  REPS2 | 0.07 | 0.104           |          |
|  ITSN2 |  SYNRG | 0.069 | 0.102           |          |
|  RALBP1 |  COMT | 0.069 | 0.0961333333333           |          |
|  RALBP1 |  HEATR5B | 0.069 | 0.162           |          |
|  AP1S1 |  REPS2 | 0.068 | 0.074           |          |
|  AP2S1 |  HEATR5B | 0.068 | 0.1           |          |
|  REPS2 |  MEA1 | 0.067 | 0.082           |          |
|  SYNJ1 |  REPS2 | 0.066 | 0.052           |          |
|  SYNRG |  COMT | 0.066 | 0.076           |          |
|  EPS15L1 |  AFTPH | 0.065 | 0.222           |          |
|  EPS15L1 |  AP1M2 | 0.064 | 0.11           |          |
|  AP2B1 |  REPS2 | 0.063 | 0.14           |          |
|  NECAP2 |  COMT | 0.062 | 0.048           |          |
|  SYNJ1 |  AP1G2 | 0.061 | 0.042           |          |
|  AP2A2 |  AFTPH | 0.061 | 0.148           |          |
|  AP2S1 |  KIF13A | 0.055 |            |          |
|  NECAP1 |  COMT | 0.055 | 0.036           |          |
|  AP2A2 |  REPS2 | 0.054 | 0.182           |          |
|  ITSN2 |  COMT | 0.051 | 0.07           |          |
|  ITSN1 |  KIF13A | 0.05 |            |          |
|  ITSN1 |  RUNDC3B | 0.05 |            |          |
|  CCDC32 |  AP1G2 | 0.05 | 0.06           |          |
|  HEATR5B |  COMT | 0.05 | 0.028           |          |
|  AP2A2 |  KIF13A | 0.049 |            |          |
|  ITSN2 |  HEATR5B | 0.048 | 0.084           |          |
|  AP2S1 |  AFTPH | 0.048 | 0.114           |          |
|  ITSN1 |  HEATR5B | 0.047 |            |          |
|  EPS15L1 |  KIF13A | 0.045 |            |          |
|  AP1B1 |  REPS2 | 0.043 | 0.164           |          |
|  CCDC32 |  AP1S1 | 0.043 | 0.06           |          |
|  SYNJ1 |  HEATR5B | 0.042 | 0.086           |          |
|  ITSN2 |  REPS1 | 0.037 | 0.042           |          |
|  AP2A2 |  HEATR5B | 0.037 | 0.282818181818           |          |
|  AP2S1 |  COMT | 0.036 | 0.078           |          |
|  AP2S1 |  SYNRG | 0.034 | 0.104           |          |
|  AP1M2 |  RUNDC3A | 0.031 |            |          |
|  ITSN1 |  REPS2 | 0.031 |            |          |
|  SYNJ1 |  COMT | 0.03 | 0.042           |          |
|  AP2A2 |  SYNRG | 0.03 | 0.114428571429           |          |
|  ITSN2 |  NECAP2 | 0.029 | 0.07           |          |
|  ITSN1 |  COMT | 0.028 |            |          |
|  HEATR5B |  REPS1 | 0.025 | 0.036           |          |
|  ITSN2 |  CCDC32 | 0.024 | 0.05           |          |
|  REPS2 |  SYNRG | 0.021 | 0.184           |          |
|  ITSN2 |  AAGAB | 0.02 | 0.042           |          |
|  ITSN2 |  AP1M1 | 0.02 | 0.096           |          |
|  ITSN2 |  REPS2 | 0.019 | 0.126           |          |
|  NECAP2 |  REPS2 | 0.018 | 0.076           |          |
|  REPS1 |  COMT | 0.016 | 0.078           |          |
|  AAGAB |  COMT | 0.016 | 0.052           |          |
|  EPS15L1 |  REPS2 | 0.015 | 0.202           |          |
|  REPS2 |  AP1G2 | 0.015 | 0.04           |          |
|  EPS15L1 |  SYNRG | 0.014 | 0.116           |          |
|  ITSN1 |  SYNRG | 0.011 |            |          |
|  ITSN2 |  AP1M2 | 0.011 | 0.054           |          |
|  KIF13A |  COMT | 0.009 |            |          |
|  NECAP2 |  SYNRG | 0.008 | 0.1           |          |
|  EPS15L1 |  COMT | 0.008 | 0.09           |          |
|  AP2B1 |  COMT | 0.007 | 0.172           |
structurally_consistent (Q9BXS5)        
|
|  AP1M2 |  COMT | 0.007 | 0.084           |          |
|  NECAP2 |  AFTPH | 0.006 | 0.046           |          |
|  REPS2 |  AFTPH | 0.005 | 0.21           |          |
|  CCDC32 |  COMT | 0.004 | 0.032           |          |
Related Complexes