hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12377.1
Complex Portal: CPX-19694
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GGNBP2 | Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403) | 4 | UniProt NCBI |
| FBN1 | Fibrillin-1 [Cleaved into: Asprosin] | 5 | UniProt NCBI |
| ZXDB | Zinc finger X-linked protein ZXDB | 4 | UniProt NCBI |
| ZNF408 | Zinc finger protein 408 (PR domain zinc finger protein 17) | 5 | UniProt NCBI |
| NTN5 | Netrin-5 (Netrin-1-like protein) | 3 | UniProt NCBI |
| FBLN5 | Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50) | 5 | UniProt NCBI |
| LTBP1 | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | 5 | UniProt NCBI |
| FOXG1 | Forkhead box protein G1 (Brain factor 1) (BF-1) (BF1) (Brain factor 2) (BF-2) (BF2) (hBF-2) (Forkhead box protein G1A) (Forkhead box protein G1B) (Forkhead box protein G1C) (Forkhead-related protein FKHL1) (HFK1) (Forkhead-related protein FKHL2) (HFK2) (Forkhead-related protein FKHL3) (HFK3) | 5 | UniProt NCBI |
| FBN2 | Fibrillin-2 [Cleaved into: Placensin] | 5 | UniProt NCBI |
| ZFP41 | Zinc finger protein 41 homolog (Zfp-41) | 4 | UniProt NCBI |
| TKTL2 | Transketolase-like protein 2 (EC 2.2.1.1) | 4 | UniProt NCBI |
| ZNF331 | Zinc finger protein 331 (C2H2-like zinc finger protein rearranged in thyroid adenomas) (Zinc finger protein 361) (Zinc finger protein 463) | 3 | UniProt NCBI |
| CRIM1 | Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] | 5 | UniProt NCBI |
| HOXB3 | Homeobox protein Hox-B3 (Homeobox protein Hox-2.7) (Homeobox protein Hox-2G) | 5 | UniProt NCBI |
| ZIC3 | Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3) | 5 | UniProt NCBI |
| ZNF737 | Zinc finger protein 737 (Zinc finger protein 102) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2129379 | 6.5430894935e-06 | 0.25 | FBN2 FBLN5 FBN1 LTBP1 | Molecules associated with elastic fibres |
| REAC:R-HSA-1566948 | 1.61530066007e-05 | 0.25 | FBN2 FBLN5 FBN1 LTBP1 | Elastic fibre formation |
| CORUM:6914 | 5.10764421909e-05 | 0.125 | FBLN5 FBN1 | ELN-FBLN5-FBN1 complex |
| GO:0035583 | 0.000215165225046 | 0.1875 | LTBP1 FBN1 FBN2 | sequestering of TGFbeta in extracellular matrix |
| WP:WP3668 | 0.000239264331462 | 0.1875 | LTBP1 FBN1 FBN2 | Hypothesized pathways in pathogenesis of cardiovascular disease |
| GO:0071694 | 0.000537554131189 | 0.1875 | LTBP1 FBN1 FBN2 | maintenance of protein location in extracellular region |
| GO:0035581 | 0.00187892941497 | 0.1875 | LTBP1 FBN1 FBN2 | sequestering of extracellular ligand from receptor |
| GO:0001527 | 0.00300428100757 | 0.1875 | LTBP1 FBN1 FBN2 | microfibril |
| HP:0012772 | 0.00366183923443 | 0.125 | FBN1 FBN2 | Abnormal upper to lower segment ratio |
| HP:0002256 | 0.00366183923443 | 0.125 | FBLN5 LTBP1 | Small bowel diverticula |
| GO:0030023 | 0.00450341440411 | 0.1875 | FBLN5 FBN1 FBN2 | extracellular matrix constituent conferring elasticity |
| GO:1900116 | 0.00450341440411 | 0.1875 | LTBP1 FBN1 FBN2 | extracellular negative regulation of signal transduction |
| GO:1900115 | 0.00450341440411 | 0.1875 | LTBP1 FBN1 FBN2 | extracellular regulation of signal transduction |
| HP:0012619 | 0.00731900096398 | 0.125 | FBLN5 LTBP1 | Multiple bladder diverticula |
| HP:0008722 | 0.00731900096398 | 0.125 | FBLN5 LTBP1 | Urethral diverticulum |
| GO:0097493 | 0.00883419058623 | 0.1875 | FBLN5 FBN1 FBN2 | structural molecule activity conferring elasticity |
| HP:0009901 | 0.0121905443004 | 0.125 | FBN1 FBN2 | Crumpled ear |
| HP:0031481 | 0.0181708995785 | 0.25 | FBLN5 ZIC3 FBN1 FBN2 | Abnormal mitral valve physiology |
| HP:0025082 | 0.0182741382889 | 0.125 | FBLN5 LTBP1 | Abnormal cutaneous elastic fiber morphology |
| HP:0025167 | 0.0182741382889 | 0.125 | FBLN5 LTBP1 | Fragmented elastic fibers in the dermis |
| HP:0001384 | 0.0204644979372 | 0.3125 | FBN2 FBLN5 ZIC3 FBN1 LTBP1 | Abnormal hip joint morphology |
| HP:0031653 | 0.0223517682033 | 0.3125 | FBN2 FBLN5 ZIC3 FBN1 LTBP1 | Abnormal heart valve physiology |
| HP:0100679 | 0.0235999694377 | 0.1875 | FBLN5 FBN1 LTBP1 | Lack of skin elasticity |
| HP:0001373 | 0.0250768570683 | 0.3125 | FBN2 FBLN5 ZIC3 FBN1 LTBP1 | Joint dislocation |
| HP:0010750 | 0.0255674550878 | 0.125 | FBLN5 LTBP1 | Dermatochalasis |
| REAC:R-HSA-1474244 | 0.0264930775263 | 0.25 | FBN2 FBLN5 FBN1 LTBP1 | Extracellular matrix organization |
| HP:0002097 | 0.0265121239957 | 0.1875 | FBLN5 FBN1 LTBP1 | Emphysema |
| HP:0031650 | 0.0383659247062 | 0.25 | FBLN5 ZIC3 FBN1 FBN2 | Abnormal atrioventricular valve physiology |
| HP:0004930 | 0.0392119651394 | 0.25 | FBLN5 ZIC3 FBN1 LTBP1 | Abnormality of the pulmonary vasculature |
| HP:0002617 | 0.0418323837618 | 0.25 | FBN2 FBLN5 FBN1 LTBP1 | Vascular dilatation |
| HP:0006698 | 0.043773961294 | 0.125 | FBLN5 LTBP1 | Dilatation of the ventricular cavity |
| HP:0002107 | 0.0468076554228 | 0.1875 | FBLN5 FBN1 LTBP1 | Pneumothorax |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| ZFP41 | GGNBP2 | 0.995 | ||
| ZFP41 | FBN1 | 0.988 | ||
| FBN1 | NTN5 | 0.985 | ||
| ZNF331 | GGNBP2 | 0.974 | ||
| ZFP41 | FBLN5 | 0.962 | ||
| FBLN5 | LTBP1 | 0.942 | ||
| ZFP41 | LTBP1 | 0.94 | ||
| FBLN5 | ZIC3 | 0.936 | ||
| ZNF408 | LTBP1 | 0.935 | ||
| FBN1 | ZNF331 | 0.934 | ||
| FBLN5 | ZXDB | 0.932 | ||
| ZFP41 | FBN2 | 0.928 | ||
| FBLN5 | ZNF737 | 0.927 | ||
| FBLN5 | ZNF408 | 0.926 | ||
| FBLN5 | FBN2 | 0.92 | 0.182 | |
| ZNF408 | FBN2 | 0.91 | ||
| FOXG1 | FBLN5 | 0.899 | ||
| FBN1 | FBLN5 | 0.889 | 0.314 | |
| FBLN5 | TKTL2 | 0.884 | ||
| FBLN5 | NTN5 | 0.884 | ||
| CRIM1 | ZNF408 | 0.868 | ||
| FBLN5 | HOXB3 | 0.805 | ||
| FBLN5 | ZNF331 | 0.782 | ||
| FBN1 | FBN2 | 0.745 | 0.293 | |
| FBN1 | ZNF408 | 0.725 | ||
| FBN1 | LTBP1 | 0.437 | 0.232 | |
| ZIC3 | ZNF737 | 0.415 | ||
| ZNF408 | ZNF737 | 0.415 | ||
| FOXG1 | ZIC3 | 0.415 | ||
| FOXG1 | ZNF737 | 0.415 | ||
| NTN5 | FBN2 | 0.405 | ||
| LTBP1 | NTN5 | 0.311 | ||
| FBLN5 | GGNBP2 | 0.281 | ||
| FBN1 | GGNBP2 | 0.281 | 0.022 | |
| FBN1 | CRIM1 | 0.262 | 0.048 | |
| ZNF408 | ZIC3 | 0.25 | ||
| CRIM1 | FBLN5 | 0.218 | ||
| CRIM1 | LTBP1 | 0.157 | 0.082 | |
| ZNF331 | FBN2 | 0.133 | ||
| GGNBP2 | LTBP1 | 0.119 | 0.062 | |
| LTBP1 | FBN2 | 0.114 | 0.222 | |
| CRIM1 | FBN2 | 0.114 | 0.14 | |
| GGNBP2 | FBN2 | 0.113 | 0.128 | |
| FOXG1 | ZNF408 | 0.113 | ||
| LTBP1 | ZIC3 | 0.102 | ||
| FOXG1 | LTBP1 | 0.087 | ||
| LTBP1 | ZNF737 | 0.076 | ||
| FBN2 | ZNF737 | 0.065 | ||
| FBN2 | ZIC3 | 0.064 | ||
| FOXG1 | FBN2 | 0.06 |
Related Complexes