hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12380.1
Complex Portal: CPX-12001
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAPK4 | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | 5 | UniProt NCBI |
| ASTL | Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase) | 5 | UniProt NCBI |
| MAPK6 | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | 5 | UniProt NCBI |
| MAPKAPK5 | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7548 | 1.53774525569e-05 | 0.5 | MAPKAPK5 MAPK6 | MAPK6-MAPKAPK5-SEPT7 complex |
| REAC:R-HSA-5687128 | 0.000119242757257 | 0.75 | MAPKAPK5 MAPK4 MAPK6 | MAPK6/MAPK4 signaling |
| WP:WP26 | 0.000644879603036 | 0.5 | MAPK4 MAPK6 | S1P receptor signal transduction |
| REAC:R-HSA-5683057 | 0.00352209873575 | 0.75 | MAPKAPK5 MAPK4 MAPK6 | MAPK family signaling cascades |
| WP:WP4538 | 0.00449637847065 | 0.5 | MAPK4 MAPK6 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:04657 | 0.00728891894502 | 0.5 | MAPK4 MAPK6 | IL-17 signaling pathway |
| WP:WP185 | 0.00883615359641 | 0.5 | MAPK4 MAPK6 | Integrin mediated cell adhesion |
| WP:WP3931 | 0.0125286636678 | 0.5 | MAPK4 MAPK6 | Embryonic stem cell pluripotency pathways |
| WP:WP4787 | 0.0130350149263 | 0.5 | MAPK4 MAPK6 | Osteoblast differentiation and related diseases |
| WP:WP3915 | 0.0162815495406 | 0.5 | MAPK4 MAPK6 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP51 | 0.0205195911139 | 0.5 | MAPK4 MAPK6 | Regulation of actin cytoskeleton |
| WP:WP481 | 0.0255965717397 | 0.5 | MAPK4 MAPK6 | Insulin signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAPK6 | MAPKAPK5 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAPK4 | MAPK6 | 0.999 |
mutually_exclusive (Q8IW41)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAPK4 | MAPKAPK5 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ASTL | MAPK4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ASTL | MAPK6 | 0.904 | bioplex3_WMM WMM_only | ||
| ASTL | MAPKAPK5 | 0.902 | bioplex3_WMM WMM_only |
Related Complexes