hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12383.1
Complex Portal: CPX-16452
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GIGYF1 | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | 5 | UniProt NCBI |
| EIF4EBP3 | Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3) | 5 | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | 5 | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | 5 | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | 5 | UniProt NCBI |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | 5 | UniProt NCBI |
| EIF4ENIF1 | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | 5 | UniProt NCBI |
| EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | 2 | UniProt NCBI |
| ANGEL1 | Protein angel homolog 1 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 3.90843971834e-09 | 0.555555555556 | EIF4EBP2 EIF4EBP3 EIF4E EIF4G3 EIF4EBP1 | Translation factors |
| GO:0031369 | 9.11335941896e-08 | 0.555555555556 | EIF4EBP3 ANGEL1 EIF4EBP2 EIF4E EIF4EBP1 | translation initiation factor binding |
| GO:0008190 | 2.31823352537e-07 | 0.444444444444 | EIF4EBP3 ANGEL1 EIF4EBP2 EIF4EBP1 | eukaryotic initiation factor 4E binding |
| GO:0045182 | 6.53205979867e-07 | 0.666666666667 | EIF4EBP1 EIF4E1B EIF4G3 EIF4EBP3 EIF4E EIF4EBP2 | translation regulator activity |
| GO:0016281 | 2.3646695756e-06 | 0.444444444444 | EIF4EBP3 EIF4E1B EIF4G3 EIF4E | eukaryotic translation initiation factor 4F complex |
| GO:0034518 | 6.01421448879e-06 | 0.444444444444 | EIF4EBP3 EIF4E1B EIF4G3 EIF4E | RNA cap binding complex |
| GO:0006413 | 0.000107075384876 | 0.555555555556 | EIF4EBP2 EIF4EBP3 EIF4E EIF4G3 EIF4EBP1 | translational initiation |
| GO:0006417 | 0.000141026676709 | 0.666666666667 | EIF4EBP1 EIF4ENIF1 EIF4G3 EIF4EBP3 EIF4E EIF4EBP2 | regulation of translation |
| WP:WP4566 | 0.000155232788201 | 0.333333333333 | EIF4EBP1 EIF4G3 EIF4E | Translation inhibitors in chronically activated PDGFRA cells |
| GO:0034248 | 0.000380306323592 | 0.666666666667 | EIF4EBP1 EIF4ENIF1 EIF4G3 EIF4EBP3 EIF4E EIF4EBP2 | regulation of amide metabolic process |
| KEGG:01521 | 0.000517754441228 | 0.333333333333 | EIF4EBP1 EIF4E EIF4E1B | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04211 | 0.000679986209508 | 0.333333333333 | EIF4EBP1 EIF4E EIF4E1B | Longevity regulating pathway |
| KEGG:04066 | 0.00124312860357 | 0.333333333333 | EIF4EBP1 EIF4E EIF4E1B | HIF-1 signaling pathway |
| GO:0010608 | 0.00147179564623 | 0.666666666667 | EIF4EBP1 EIF4ENIF1 EIF4G3 EIF4EBP3 EIF4E EIF4EBP2 | post-transcriptional regulation of gene expression |
| KEGG:04910 | 0.00255835080133 | 0.333333333333 | EIF4EBP1 EIF4E EIF4E1B | Insulin signaling pathway |
| GO:0006446 | 0.00316270648564 | 0.444444444444 | EIF4EBP3 EIF4EBP2 EIF4G3 EIF4EBP1 | regulation of translational initiation |
| KEGG:04150 | 0.00413269570012 | 0.333333333333 | EIF4EBP1 EIF4E EIF4E1B | mTOR signaling pathway |
| WP:WP516 | 0.00468193988771 | 0.222222222222 | EIF4EBP1 EIF4E | Hypertrophy model |
| WP:WP3879 | 0.00642003616322 | 0.222222222222 | EIF4EBP1 EIF4E | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| GO:0000339 | 0.00655807506899 | 0.333333333333 | EIF4E1B EIF4G3 EIF4E | RNA cap binding |
| GO:0006412 | 0.00904821131641 | 0.666666666667 | EIF4EBP1 EIF4ENIF1 EIF4G3 EIF4EBP3 EIF4E EIF4EBP2 | translation |
| GO:0045947 | 0.00915637133828 | 0.333333333333 | EIF4EBP3 EIF4EBP2 EIF4EBP1 | negative regulation of translational initiation |
| GO:0043043 | 0.0107721373575 | 0.666666666667 | EIF4EBP1 EIF4ENIF1 EIF4G3 EIF4EBP3 EIF4E EIF4EBP2 | peptide biosynthetic process |
| GO:0017148 | 0.0142653929889 | 0.444444444444 | EIF4EBP3 EIF4EBP2 EIF4ENIF1 EIF4EBP1 | negative regulation of translation |
| GO:0030371 | 0.020844368733 | 0.333333333333 | EIF4EBP3 EIF4EBP2 EIF4EBP1 | translation repressor activity |
| REAC:R-HSA-166208 | 0.0218931941247 | 0.222222222222 | EIF4EBP1 EIF4E | mTORC1-mediated signalling |
| GO:0034249 | 0.0272753050284 | 0.444444444444 | EIF4EBP3 EIF4EBP2 EIF4ENIF1 EIF4EBP1 | negative regulation of amide metabolic process |
| KEGG:04151 | 0.0288560061328 | 0.333333333333 | EIF4EBP1 EIF4E EIF4E1B | PI3K-Akt signaling pathway |
| GO:0043604 | 0.0307215481082 | 0.666666666667 | EIF4EBP1 EIF4ENIF1 EIF4G3 EIF4EBP3 EIF4E EIF4EBP2 | amide biosynthetic process |
| GO:0006518 | 0.0332819620894 | 0.666666666667 | EIF4EBP1 EIF4ENIF1 EIF4G3 EIF4EBP3 EIF4E EIF4EBP2 | peptide metabolic process |
| WP:WP3932 | 0.0343032557242 | 0.333333333333 | EIF4EBP1 EIF4E EIF4E1B | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP585 | 0.0386069386725 | 0.222222222222 | EIF4EBP1 EIF4E | Interferon type I signaling pathways |
| WP:WP4172 | 0.0444870284412 | 0.333333333333 | EIF4EBP1 EIF4E EIF4E1B | PI3K Akt signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4E | EIF4ENIF1 | 0.999 | 0.2115 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EIF4E | EIF4G3 | 0.999 | 0.21 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| EIF4E | EIF4EBP2 | 0.998 | 0.124 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4E | ANGEL1 | 0.998 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EIF4EBP1 | EIF4E | 0.998 | 0.1384 |
mutually_exclusive (A6NMX2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4E1B | EIF4E | 0.982 |
mutually_exclusive (Q13541)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4EBP2 | 0.982 | 0.042 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4EBP1 | 0.977 |
mutually_exclusive (P06730)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4G3 | 0.908 | 0.148 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E1B | EIF4EBP2 | 0.904 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4G3 | EIF4EBP2 | 0.902 | 0.03 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E | EIF4EBP3 | 0.886 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EIF4G3 | EIF4ENIF1 | 0.885 | 0.138 |
mutually_exclusive (P06730)
|
youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ANGEL1 | EIF4ENIF1 | 0.872 | 0.15 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP2 | ANGEL1 | 0.845 | 0.066 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP2 | EIF4ENIF1 | 0.834 | 0.178 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4G3 | 0.675 | bioplex3_WMM WMM_only | ||
| EIF4G3 | ANGEL1 | 0.663 | 0.066 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP1 | EIF4ENIF1 | 0.588 | 0.056 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| EIF4E1B | EIF4ENIF1 | 0.388 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4E1B | ANGEL1 | 0.367 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4EBP1 | ANGEL1 | 0.325 | 0.06 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes