hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12400.1
Complex Portal: CPX-24018
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NLGN1 | Neuroligin-1 | 5 | UniProt NCBI |
| NLGN3 | Neuroligin-3 (Gliotactin homolog) | 5 | UniProt NCBI |
| NLGN4Y | Neuroligin-4, Y-linked (Neuroligin Y) | 5 | UniProt NCBI |
| RECQL4 | ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4) | 5 | UniProt NCBI |
| NLGN4X | Neuroligin-4, X-linked (Neuroligin X) (HNLX) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0098985 | 1.31563155046e-10 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | asymmetric, glutamatergic, excitatory synapse |
| GO:0097104 | 1.97323122031e-09 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | postsynaptic membrane assembly |
| GO:0097105 | 9.20740386965e-09 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | presynaptic membrane assembly |
| GO:0097090 | 1.65724193228e-08 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | presynaptic membrane organization |
| GO:0060077 | 1.65724193228e-08 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | inhibitory synapse |
| GO:0007158 | 2.76191861336e-08 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | neuron cell-cell adhesion |
| GO:0099068 | 6.50952358374e-08 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | postsynapse assembly |
| GO:0042043 | 6.50952358374e-08 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | neurexin family protein binding |
| REAC:R-HSA-6794361 | 6.95446825874e-08 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | Neurexins and neuroligins |
| GO:0098982 | 1.31622611039e-07 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | GABA-ergic synapse |
| GO:0001941 | 1.79475545894e-07 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | postsynaptic membrane organization |
| REAC:R-HSA-6794362 | 3.9023921419e-07 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | Protein-protein interactions at synapses |
| GO:0060076 | 4.02274655956e-07 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | excitatory synapse |
| WP:WP5398 | 4.39047705433e-07 | 0.6 | NLGN3 NLGN1 NLGN4X | NRXN1 deletion syndrome |
| KEGG:04514 | 5.84108444617e-07 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | Cell adhesion molecules |
| GO:0099054 | 1.16377978294e-06 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | presynapse assembly |
| GO:0099172 | 1.396459195e-06 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | presynapse organization |
| WP:WP4875 | 2.77106908724e-06 | 0.6 | NLGN3 NLGN1 NLGN4X | Disruption of postsynaptic signaling by CNV |
| GO:0098983 | 3.84440695359e-06 | 0.6 | NLGN3 NLGN4X NLGN4Y | symmetric, GABA-ergic, inhibitory synapse |
| GO:0032280 | 1.92180881975e-05 | 0.6 | NLGN3 NLGN4X NLGN4Y | symmetric synapse |
| GO:0048488 | 1.95582475037e-05 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | synaptic vesicle endocytosis |
| GO:0140238 | 1.95582475037e-05 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | presynaptic endocytosis |
| GO:0097110 | 2.34110134044e-05 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | scaffold protein binding |
| GO:0071709 | 2.78063937229e-05 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | membrane assembly |
| GO:0044091 | 3.5523826943e-05 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | membrane biogenesis |
| GO:0036465 | 4.14930734417e-05 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | synaptic vesicle recycling |
| GO:0071625 | 5.37995977657e-05 | 0.6 | NLGN3 NLGN4X NLGN4Y | vocalization behavior |
| GO:0098978 | 0.000100492682129 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | glutamatergic synapse |
| REAC:R-HSA-112316 | 0.000135335223169 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | Neuronal System |
| GO:0099173 | 0.000186904603412 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | postsynapse organization |
| HP:0000721 | 0.000384717178033 | 0.4 | NLGN3 NLGN4X | Lack of spontaneous play |
| HP:5200104 | 0.000384717178033 | 0.4 | NLGN3 NLGN4X | Abnormal play |
| GO:0007416 | 0.00043484599868 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | synapse assembly |
| GO:0099504 | 0.000625424261446 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | synaptic vesicle cycle |
| GO:0099003 | 0.000701044598266 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | vesicle-mediated transport in synapse |
| GO:0035176 | 0.000929874009882 | 0.6 | NLGN3 NLGN4X NLGN4Y | social behavior |
| HP:5200130 | 0.000961529670085 | 0.4 | NLGN3 NLGN4X | Insistence on sameness |
| HP:0000732 | 0.000961529670085 | 0.4 | NLGN3 NLGN4X | Inflexible adherence to routines |
| GO:0032279 | 0.00103813210542 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | asymmetric synapse |
| GO:0098984 | 0.00122611762455 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | neuron to neuron synapse |
| GO:0051703 | 0.00127603542925 | 0.6 | NLGN3 NLGN4X NLGN4Y | biological process involved in intraspecies interaction between organisms |
| HP:5200016 | 0.001345957274 | 0.4 | NLGN3 NLGN4X | Abnormal peer relationships |
| HP:0002332 | 0.001345957274 | 0.4 | NLGN3 NLGN4X | Lack of peer relationships |
| GO:0098815 | 0.00169879277018 | 0.6 | NLGN3 NLGN1 NLGN4X | modulation of excitatory postsynaptic potential |
| WP:WP5420 | 0.00344420491582 | 0.6 | NLGN3 NLGN1 NLGN4X | ADHD and autism ASD linked metabolic pathways and SNP |
| HP:0003144 | 0.00422725674544 | 0.4 | NLGN3 NLGN4X | Increased serum serotonin |
| HP:5200024 | 0.00499516489297 | 0.4 | NLGN3 NLGN4X | Abnormal relationship |
| GO:0060079 | 0.00522817157061 | 0.6 | NLGN3 NLGN1 NLGN4X | excitatory postsynaptic potential |
| GO:0007610 | 0.00602060942924 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | behavior |
| GO:0099565 | 0.00744248347584 | 0.6 | NLGN3 NLGN1 NLGN4X | chemical synaptic transmission, postsynaptic |
| HP:0000723 | 0.00768171284681 | 0.4 | NLGN3 NLGN4X | Restrictive behavior |
| GO:0050804 | 0.00792260312428 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | modulation of chemical synaptic transmission |
| GO:0099177 | 0.00808550830502 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | regulation of trans-synaptic signaling |
| GO:0007612 | 0.0102064666638 | 0.6 | NLGN3 NLGN4X NLGN4Y | learning |
| GO:0060078 | 0.011813517648 | 0.6 | NLGN3 NLGN1 NLGN4X | regulation of postsynaptic membrane potential |
| GO:0050808 | 0.0125732528527 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | synapse organization |
| GO:0031644 | 0.0237169649094 | 0.6 | NLGN3 NLGN1 NLGN4X | regulation of nervous system process |
| GO:0034329 | 0.0272504151846 | 0.8 | NLGN3 NLGN4X NLGN1 NLGN4Y | cell junction assembly |
| CORUM:7344 | 0.0498708842806 | 0.2 | NLGN1 | NLGN1-NRXN1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NLGN4Y | NLGN3 | 0.985 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NLGN3 | NLGN1 | 0.984 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NLGN3 | NLGN4X | 0.984 |
mutually_exclusive (Q8N2Q7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NLGN3 | RECQL4 | 0.82 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NLGN4Y | NLGN4X | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NLGN4X | NLGN1 | 0.543 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| NLGN4Y | NLGN1 | 0.502 |
mutually_exclusive (Q9NZ94)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| NLGN1 | RECQL4 | 0.279 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| NLGN4X | RECQL4 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NLGN4Y | RECQL4 | 0.103 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| NLGN1 | huMAP3_03089.1 huMAP3_07911.1 huMAP3_12400.1 |
| NLGN3 | huMAP3_03089.1 huMAP3_07911.1 huMAP3_12400.1 |
| NLGN4Y | huMAP3_02748.1 huMAP3_03089.1 huMAP3_04162.1 huMAP3_04886.1 huMAP3_06980.1 huMAP3_08676.1 huMAP3_09716.1 huMAP3_11222.1 huMAP3_12400.1 |
| RECQL4 | huMAP3_12400.1 |
| NLGN4X | huMAP3_03089.1 huMAP3_07911.1 huMAP3_12400.1 |