hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12407.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GCLM | Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) | 5 | UniProt NCBI |
| GCLC | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | 5 | UniProt NCBI |
| RCC2 | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | 5 | UniProt NCBI |
| MTPN | Myotrophin (Protein V-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7186 | 5.12628525639e-06 | 0.5 | GCLM GCLC | Glutamate-cysteine ligase |
| REAC:R-HSA-5578999 | 1.02525705128e-05 | 0.5 | GCLM GCLC | Defective GCLC causes HAGGSD |
| WP:WP3 | 0.000232143427839 | 0.5 | GCLM GCLC | Transcriptional activation by NRF2 in response to phytochemicals |
| WP:WP100 | 0.000346844620397 | 0.5 | GCLM GCLC | Glutathione metabolism |
| REAC:R-HSA-174403 | 0.000563428413222 | 0.5 | GCLM GCLC | Glutathione synthesis and recycling |
| WP:WP3612 | 0.000588856887782 | 0.5 | GCLM GCLC | Photodynamic therapy induced NFE2L2 NRF2 survival signaling |
| WP:WP4357 | 0.000588856887782 | 0.5 | GCLM GCLC | NRF2 ARE regulation |
| WP:WP5113 | 0.000828175715845 | 0.5 | GCLM GCLC | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway |
| REAC:R-HSA-9818027 | 0.00122873738811 | 0.5 | GCLM GCLC | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| REAC:R-HSA-5579029 | 0.0013924419067 | 0.5 | GCLM GCLC | Metabolic disorders of biological oxidation enzymes |
| KEGG:04216 | 0.00157527945983 | 0.5 | GCLM GCLC | Ferroptosis |
| WP:WP3940 | 0.0022974831852 | 0.5 | GCLM GCLC | One carbon metabolism and related pathways |
| KEGG:00270 | 0.0025855951209 | 0.5 | GCLM GCLC | Cysteine and methionine metabolism |
| GO:0004357 | 0.0028092043205 | 0.5 | GCLM GCLC | glutamate-cysteine ligase activity |
| GO:0017109 | 0.0028092043205 | 0.5 | GCLM GCLC | glutamate-cysteine ligase complex |
| KEGG:00480 | 0.0030591266514 | 0.5 | GCLM GCLC | Glutathione metabolism |
| WP:WP2525 | 0.00377411060353 | 0.5 | GCLM GCLC | Trans sulfuration one carbon metabolism and related pathways |
| WP:WP4313 | 0.00419992835715 | 0.5 | GCLM GCLC | Ferroptosis |
| REAC:R-HSA-156590 | 0.00507136546841 | 0.5 | GCLM GCLC | Glutathione conjugation |
| WP:WP2884 | 0.015715675352 | 0.5 | GCLM GCLC | NRF2 pathway |
| KEGG:01240 | 0.0220824431074 | 0.5 | GCLM GCLC | Biosynthesis of cofactors |
| REAC:R-HSA-9759194 | 0.0305753786405 | 0.5 | GCLM GCLC | Nuclear events mediated by NFE2L2 |
| REAC:R-HSA-156580 | 0.0321680026233 | 0.5 | GCLM GCLC | Phase II - Conjugation of compounds |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GCLM | GCLC | 1.0 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| GCLM | RCC2 | 0.932 | 0.028 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| RCC2 | MTPN | 0.81 | 0.052 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| GCLM | MTPN | 0.048 | 0.03 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only |
| GCLC | RCC2 | 0.035 | 0.042 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes