hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12416.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NPW | Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8); Neuropeptide W-30 (NPW30) (hL8C)] | 4 | UniProt NCBI |
| HS3ST1 | Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1) | 5 | UniProt NCBI |
| IFNE | Interferon epsilon (IFN-epsilon) (Interferon epsilon-1) | 4 | UniProt NCBI |
| TAS1R2 | Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2) | 5 | UniProt NCBI |
| CGREF1 | Cell growth regulator with EF hand domain protein 1 (Cell growth regulatory gene 11 protein) (Hydrophobestin) | 5 | UniProt NCBI |
| BMP4 | Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) | 5 | UniProt NCBI |
| VGF | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] | 5 | UniProt NCBI |
| IL10 | Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) | 5 | UniProt NCBI |
| B4GALT5 | Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5) | 5 | UniProt NCBI |
| VIP | VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)] | 5 | UniProt NCBI |
| CSF2 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim) | 5 | UniProt NCBI |
| NMU | Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36 (NURP36); Neuromedin precursor-related peptide 33 (NURP33); Neuromedin-U-25 (NmU-25)] | 5 | UniProt NCBI |
| IL20 | Interleukin-20 (IL-20) (Cytokine Zcyto10) | 5 | UniProt NCBI |
| NXPH2 | Neurexophilin-2 | 3 | UniProt NCBI |
| ST8SIA2 | Alpha-2,8-sialyltransferase 8B (EC 2.4.3.-) (Sialyltransferase 8B) (SIAT8-B) (Sialyltransferase St8Sia II) (ST8SiaII) (Sialyltransferase X) (STX) | 5 | UniProt NCBI |
| PMCH | Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)] | 4 | UniProt NCBI |
| CORT | Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17] | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04080 | 3.29628417911e-05 | 0.357142857143 | NMU VIP CORT NPW VGF | Neuroactive ligand-receptor interaction |
| REAC:R-HSA-500792 | 0.000453113091535 | 0.357142857143 | NMU TAS1R2 CORT NPW VIP | GPCR ligand binding |
| GO:0005102 | 0.00178116614782 | 0.642857142857 | CSF2 IFNE NMU NXPH2 NPW CORT IL20 VIP VGF | signaling receptor binding |
| REAC:R-HSA-388396 | 0.00453310809432 | 0.357142857143 | NMU TAS1R2 CORT NPW VIP | GPCR downstream signalling |
| REAC:R-HSA-418594 | 0.0064639442466 | 0.285714285714 | TAS1R2 CORT NPW NMU | G alpha (i) signalling events |
| REAC:R-HSA-372790 | 0.00848857338745 | 0.357142857143 | NMU TAS1R2 CORT NPW VIP | Signaling by GPCR |
| KEGG:04630 | 0.0132550197928 | 0.214285714286 | CSF2 IFNE IL20 | JAK-STAT signaling pathway |
| REAC:R-HSA-975577 | 0.0249546444927 | 0.142857142857 | B4GALT5 ST8SIA2 | N-Glycan antennae elongation |
| REAC:R-HSA-375276 | 0.0266464070762 | 0.214285714286 | NMU NPW CORT | Peptide ligand-binding receptors |
| KEGG:04060 | 0.0437625237514 | 0.214285714286 | CSF2 IFNE IL20 | Cytokine-cytokine receptor interaction |
| CORUM:6137 | 0.0499958217778 | 0.0714285714286 | CSF2 | GM-CSF receptor complex |
| CORUM:6256 | 0.0499958217778 | 0.0714285714286 | CSF2 | GM-CSF-receptor complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| VGF | NXPH2 | 0.994 | |
| VGF | PMCH | 0.991 | |
| VGF | IFNE | 0.987 | |
| CORT | NPW | 0.986 | |
| VIP | VGF | 0.985 | |
| VGF | IL10 | 0.984 | |
| IL20 | VGF | 0.983 | |
| BMP4 | HS3ST1 | 0.983 | |
| PMCH | NPW | 0.981 | |
| BMP4 | NMU | 0.968 | |
| B4GALT5 | NXPH2 | 0.965 | |
| BMP4 | CGREF1 | 0.961 | |
| ST8SIA2 | HS3ST1 | 0.956 | |
| CORT | NMU | 0.955 | |
| HS3ST1 | CORT | 0.955 | |
| BMP4 | B4GALT5 | 0.951 | |
| HS3ST1 | B4GALT5 | 0.949 | |
| VGF | CGREF1 | 0.947 | 0.07 |
| B4GALT5 | NMU | 0.945 | |
| BMP4 | VIP | 0.939 | |
| BMP4 | PMCH | 0.939 | |
| BMP4 | CORT | 0.932 | |
| BMP4 | IFNE | 0.932 | |
| BMP4 | IL20 | 0.932 | |
| BMP4 | NXPH2 | 0.932 | |
| IL10 | HS3ST1 | 0.928 | |
| VIP | NMU | 0.928 | |
| HS3ST1 | IFNE | 0.918 | |
| NMU | IFNE | 0.914 | |
| ST8SIA2 | NMU | 0.914 | |
| TAS1R2 | NMU | 0.903 | |
| ST8SIA2 | B4GALT5 | 0.879 | |
| B4GALT5 | IFNE | 0.831 | |
| CGREF1 | HS3ST1 | 0.829 | |
| CORT | B4GALT5 | 0.824 | |
| B4GALT5 | CSF2 | 0.817 | |
| IL20 | HS3ST1 | 0.813 | |
| IL10 | B4GALT5 | 0.813 | |
| CGREF1 | B4GALT5 | 0.635 | 0.078 |
| HS3ST1 | NMU | 0.621 | |
| VIP | B4GALT5 | 0.596 | |
| IL20 | B4GALT5 | 0.596 | |
| PMCH | B4GALT5 | 0.35 | |
| VGF | B4GALT5 | 0.312 | 0.036 |
| BMP4 | VGF | 0.298 | |
| VGF | HS3ST1 | 0.298 | |
| BMP4 | NPW | 0.287 | |
| VGF | NPW | 0.264 | |
| VGF | NMU | 0.263 | |
| B4GALT5 | NPW | 0.254 | |
| NPW | NMU | 0.25 | |
| HS3ST1 | NPW | 0.25 |
Related Complexes