hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12423.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OAT | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form] | 5 | UniProt NCBI |
| GSTT2 | Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST class-theta-2) | 4 | UniProt NCBI |
| PDSS1 | All trans-polyprenyl-diphosphate synthase PDSS1 (All-trans-decaprenyl-diphosphate synthase subunit 1) (EC 2.5.1.91) (Decaprenyl pyrophosphate synthase subunit 1) (Decaprenyl-diphosphate synthase subunit 1) (Solanesyl-diphosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1) | 5 | UniProt NCBI |
| GPT2 | Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) | 5 | UniProt NCBI |
| MCCD1 | Mitochondrial coiled-coil domain protein 1 | 5 | UniProt NCBI |
| LBH | Protein LBH (hLBH) (Limb bud and heart development protein homolog) | 5 | UniProt NCBI |
| THEM5 | Acyl-coenzyme A thioesterase THEM5 (Acyl-CoA thioesterase THEM5) (EC 3.1.2.2) (Acyl-coenzyme A thioesterase 15) (Thioesterase superfamily member 5) | 5 | UniProt NCBI |
| THEM4 | Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4) | 5 | UniProt NCBI |
| PDSS2 | All trans-polyprenyl-diphosphate synthase PDSS2 (All-trans-decaprenyl-diphosphate synthase subunit 2) (EC 2.5.1.91) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) (Decaprenyl-diphosphate synthase subunit 2) (Solanesyl-diphosphate synthase subunit 2) | 5 | UniProt NCBI |
| GPT | Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2142789 | 0.00213354034849 | 0.2 | PDSS1 PDSS2 | Ubiquinol biosynthesis |
| WP:WP5037 | 0.00272734094269 | 0.2 | PDSS1 PDSS2 | Riboflavin and CoQ disorders |
| KEGG:00220 | 0.00360575529823 | 0.2 | GPT GPT2 | Arginine biosynthesis |
| GO:0005759 | 0.00405058992449 | 0.6 | THEM4 GPT2 THEM5 OAT PDSS1 PDSS2 | mitochondrial matrix |
| KEGG:00900 | 0.00486560074501 | 0.2 | PDSS1 PDSS2 | Terpenoid backbone biosynthesis |
| KEGG:00062 | 0.0058092018467 | 0.2 | THEM5 THEM4 | Fatty acid elongation |
| WP:WP4595 | 0.00782853915012 | 0.2 | GPT OAT | Urea cycle and associated pathways |
| KEGG:01210 | 0.00913577313997 | 0.2 | GPT GPT2 | 2-Oxocarboxylic acid metabolism |
| GO:0008483 | 0.00936146543831 | 0.3 | GPT OAT GPT2 | transaminase activity |
| KEGG:00250 | 0.00976226165365 | 0.2 | GPT GPT2 | Alanine, aspartate and glutamate metabolism |
| GO:0016769 | 0.0111127441894 | 0.3 | GPT OAT GPT2 | transferase activity, transferring nitrogenous groups |
| REAC:R-HSA-8978934 | 0.0121516690115 | 0.2 | PDSS1 PDSS2 | Metabolism of cofactors |
| GO:0047635 | 0.0210690324038 | 0.2 | GPT GPT2 | alanine-oxo-acid transaminase activity |
| GO:0097269 | 0.0210690324038 | 0.2 | PDSS1 PDSS2 | all-trans-decaprenyl-diphosphate synthase activity |
| GO:0004021 | 0.0210690324038 | 0.2 | GPT GPT2 | L-alanine:2-oxoglutarate aminotransferase activity |
| GO:0000010 | 0.0210690324038 | 0.2 | PDSS1 PDSS2 | trans-hexaprenyltranstransferase activity |
| KEGG:01230 | 0.0458118206891 | 0.2 | GPT GPT2 | Biosynthesis of amino acids |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GPT2 | THEM5 | 1.0 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPT2 | GPT | 1.0 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| THEM5 | THEM4 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OAT | THEM5 | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPT2 | THEM4 | 0.99 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| THEM4 | GSTT2 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| THEM4 | LBH | 0.985 | 0.064 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| MCCD1 | PDSS2 | 0.979 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| THEM4 | PDSS2 | 0.974 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MCCD1 | PDSS1 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PDSS1 | THEM4 | 0.932 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDSS1 | PDSS2 | 0.744 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
| OAT | THEM4 | 0.719 | 0.086 | bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM |
| GPT2 | GSTT2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| GSTT2 | PDSS2 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPT2 | PDSS2 | 0.143 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only |
| GPT2 | PDSS1 | 0.143 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only |
| PDSS1 | GSTT2 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPT2 | OAT | 0.136 | 0.22 | bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| OAT | PDSS1 | 0.044 | 0.066 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| GPT | PDSS1 | 0.027 | bioplex3_WMM WMM_only | |
| GPT | OAT | 0.011 | 0.167333333333 | bioplex3_WMM WMM_only |
| OAT | GSTT2 | 0.006 | bioplex3_HEK293 bioplex () | |
| OAT | LBH | 0.006 | 0.086 | bioplex3_HEK293 WMM_only |
| OAT | MCCD1 | 0.005 | bioplex3_HEK293 WMM_only | |
| OAT | PDSS2 | 0.003 | 0.114 | bioplex3_WMM WMM_only treiber_WMM |
Related Complexes