hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12426.1
Complex Portal: CPX-18069
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TIMP2 | Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) | 5 | UniProt NCBI |
| MMP14 | Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) | 5 | UniProt NCBI |
| MMP2 | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0005441 | 3.41752350426e-06 | 1.0 | MMP14 MMP2 | Sclerotic cranial sutures |
| HP:0006234 | 1.02525705128e-05 | 1.0 | MMP14 MMP2 | Osteolysis involving tarsal bones |
| HP:0001495 | 1.02525705128e-05 | 1.0 | MMP14 MMP2 | Carpal osteolysis |
| WP:WP129 | 8.08710334689e-05 | 1.0 | MMP14 MMP2 | Matrix metalloproteinases |
| HP:0010314 | 0.000123030846153 | 1.0 | MMP14 MMP2 | Premature thelarche |
| HP:0005994 | 0.000153788557692 | 1.0 | MMP14 MMP2 | Nodular goiter |
| HP:0000916 | 0.000187963792734 | 1.0 | MMP14 MMP2 | Broad clavicles |
| WP:WP5283 | 0.00022473634564 | 1.0 | MMP14 MMP2 | Chronic hyperglycemia impairment of neuron function |
| HP:0009134 | 0.000225556551281 | 1.0 | MMP14 MMP2 | Osteolysis involving bones of the feet |
| HP:0009139 | 0.000266566833332 | 1.0 | MMP14 MMP2 | Osteolysis involving bones of the lower limbs |
| HP:0001230 | 0.000310994638887 | 1.0 | MMP14 MMP2 | Broad metacarpals |
| KEGG:04912 | 0.00037033376401 | 1.0 | MMP14 MMP2 | GnRH signaling pathway |
| REAC:R-HSA-1592389 | 0.000471618243588 | 1.0 | MMP14 MMP2 | Activation of Matrix Metalloproteinases |
| WP:WP2324 | 0.000753377522316 | 1.0 | MMP14 MMP2 | AGE RAGE pathway |
| HP:0045039 | 0.000789447929484 | 1.0 | MMP14 MMP2 | Osteolysis involving bones of the upper limbs |
| HP:0001085 | 0.00111069513888 | 1.0 | MMP14 MMP2 | Papilledema |
| HP:0003040 | 0.00148662272435 | 1.0 | MMP14 MMP2 | Arthropathy |
| REAC:R-HSA-1442490 | 0.0020095038205 | 1.0 | MMP14 MMP2 | Collagen degradation |
| HP:0001059 | 0.00215303980768 | 1.0 | MMP14 MMP2 | Pterygium |
| HP:0000853 | 0.00338334826922 | 1.0 | MMP14 MMP2 | Goiter |
| HP:0100651 | 0.00418646629272 | 1.0 | MMP14 MMP2 | Type I diabetes mellitus |
| HP:0001539 | 0.00733058791663 | 1.0 | MMP14 MMP2 | Omphalocele |
| HP:0001719 | 0.00755614446791 | 1.0 | MMP14 MMP2 | Double outlet right ventricle |
| HP:0011723 | 0.00825331926278 | 1.0 | MMP14 MMP2 | Congenital malformation of the right heart |
| HP:0001678 | 0.00849254590808 | 1.0 | MMP14 MMP2 | Atrioventricular block |
| HP:0001191 | 0.009230730985 | 1.0 | MMP14 MMP2 | Abnormal carpal morphology |
| REAC:R-HSA-1474228 | 0.00932983916662 | 1.0 | MMP14 MMP2 | Degradation of the extracellular matrix |
| HP:0005150 | 0.00973994198714 | 1.0 | MMP14 MMP2 | Abnormal atrioventricular conduction |
| HP:0002797 | 0.0102628230833 | 1.0 | MMP14 MMP2 | Osteolysis |
| HP:0001482 | 0.0105293899166 | 1.0 | MMP14 MMP2 | Subcutaneous nodule |
| HP:0000147 | 0.0136871816346 | 1.0 | MMP14 MMP2 | Polycystic ovaries |
| HP:0000889 | 0.0146201655512 | 1.0 | MMP14 MMP2 | Abnormal clavicle morphology |
| HP:0000138 | 0.0162434892157 | 1.0 | MMP14 MMP2 | Ovarian cyst |
| HP:0001647 | 0.0165784065192 | 1.0 | MMP14 MMP2 | Bicuspid aortic valve |
| HP:0031567 | 0.0172584936965 | 1.0 | MMP14 MMP2 | Abnormal aortic valve cusp morphology |
| HP:0200036 | 0.0176036635704 | 1.0 | MMP14 MMP2 | Skin nodule |
| WP:WP5097 | 0.0186595012434 | 0.5 | MMP2 | CCL18 signaling pathway |
| HP:0012722 | 0.0190185183012 | 1.0 | MMP14 MMP2 | Heart block |
| HP:0001850 | 0.0197464508076 | 1.0 | MMP14 MMP2 | Abnormality of the tarsal bones |
| HP:0001634 | 0.0201155433461 | 1.0 | MMP14 MMP2 | Mitral valve prolapse |
| HP:0000212 | 0.0208639809935 | 1.0 | MMP14 MMP2 | Gingival overgrowth |
| CORUM:2798 | 0.0249718442457 | 0.5 | MMP2 | MMP-2-CLDN1 complex |
| CORUM:2688 | 0.0249718442457 | 0.5 | MMP14 | MMP14-CLDN1 complex |
| HP:0031546 | 0.0277776310426 | 1.0 | MMP14 MMP2 | Cardiac conduction abnormality |
| WP:WP5087 | 0.0293715080819 | 1.0 | MMP14 MMP2 | Pleural mesothelioma |
| HP:0003019 | 0.0295479082178 | 1.0 | MMP14 MMP2 | Abnormality of the wrist |
| HP:0001680 | 0.0299990213204 | 1.0 | MMP14 MMP2 | Coarctation of aorta |
| WP:WP3888 | 0.0309740314556 | 1.0 | MMP14 MMP2 | VEGFA VEGFR2 signaling |
| HP:0001633 | 0.0323058496858 | 1.0 | MMP14 MMP2 | Abnormal mitral valve morphology |
| HP:0000826 | 0.033730956987 | 1.0 | MMP14 MMP2 | Precocious puberty |
| HP:0031065 | 0.033730956987 | 1.0 | MMP14 MMP2 | Abnormal ovarian morphology |
| HP:0100000 | 0.0342128278011 | 1.0 | MMP14 MMP2 | Early onset of sexual maturation |
| HP:0011772 | 0.0392194997349 | 1.0 | MMP14 MMP2 | Abnormal thyroid morphology |
| HP:0001646 | 0.0392194997349 | 1.0 | MMP14 MMP2 | Abnormal aortic valve morphology |
| HP:0006705 | 0.0418509928331 | 1.0 | MMP14 MMP2 | Abnormal atrioventricular valve morphology |
| HP:0000612 | 0.0440177027348 | 1.0 | MMP14 MMP2 | Iris coloboma |
| REAC:R-HSA-1474244 | 0.0442193366216 | 1.0 | MMP14 MMP2 | Extracellular matrix organization |
| CORUM:6193 | 0.0499419797295 | 0.5 | MMP14 | ADAM12-alphaVbeta3-integrin-MMP-14 complex |
| HP:0008090 | 0.0499436884913 | 0.5 | MMP2 | Ankylosis of feet small joints |
| HP:0006012 | 0.0499436884913 | 0.5 | MMP2 | Widened metacarpal shaft |
| HP:0008078 | 0.0499436884913 | 0.5 | MMP2 | Thin metatarsal cortices |
| HP:0008133 | 0.0499436884913 | 0.5 | MMP2 | Distal tapering of metatarsals |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TIMP2 | MMP2 | 0.971 | 0.248 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MMP14 | TIMP2 | 0.964 | 0.21 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MMP14 | MMP2 | 0.024 | 0.302 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| TIMP2 | huMAP3_01505.1 huMAP3_11842.1 huMAP3_12426.1 huMAP3_12692.1 |
| MMP14 | huMAP3_01425.1 huMAP3_11949.1 huMAP3_12426.1 |
| MMP2 | huMAP3_01505.1 huMAP3_12426.1 huMAP3_12692.1 |