hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12434.1
Complex Portal: CPX-12614
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TTC23L | Tetratricopeptide repeat protein 23-like | 5 | UniProt NCBI |
| TTC23 | Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) | 5 | UniProt NCBI |
| IQCE | IQ domain-containing protein E | 5 | UniProt NCBI |
| EFCAB7 | EF-hand calcium-binding domain-containing protein 7 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4536 | 5.29024993618e-05 | 0.75 | TTC23 EFCAB7 IQCE | Genes related to primary cilium development based on CRISPR |
| REAC:R-HSA-5635838 | 0.000798898068561 | 0.5 | IQCE EFCAB7 | Activation of SMO |
| KEGG:04340 | 0.00247340401034 | 0.5 | IQCE EFCAB7 | Hedgehog signaling pathway |
| REAC:R-HSA-5632684 | 0.0297941212351 | 0.5 | IQCE EFCAB7 | Hedgehog 'on' state |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TTC23L | IQCE | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EFCAB7 | TTC23L | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TTC23 | IQCE | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| EFCAB7 | TTC23 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| EFCAB7 | IQCE | 0.972 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes