hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12440.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRIA4 | Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) | 5 | UniProt NCBI |
| HECTD4 | HECT domain E3 ubiquitin protein ligase 4 | 1 | UniProt NCBI |
| CCPG1 | Cell cycle progression protein 1 (Cell cycle progression restoration protein 8) | 5 | UniProt NCBI |
| SLC22A13 | Solute carrier family 22 member 13 (Organic anion transporter 10) (OAT10) (Organic cation transporter-like 3) (ORCTL-3) (ORCTL3) | 5 | UniProt NCBI |
| GRIA3 | Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-399710 | 9.11829675208e-05 | 0.4 | GRIA4 GRIA3 | Activation of AMPA receptors |
| WP:WP5398 | 0.000534376000489 | 0.4 | GRIA4 GRIA3 | NRXN1 deletion syndrome |
| WP:WP4760 | 0.00089796435942 | 0.4 | GRIA4 GRIA3 | PKC gamma calcium signaling pathway in ataxia |
| REAC:R-HSA-416993 | 0.00100191474811 | 0.4 | GRIA4 GRIA3 | Trafficking of GluR2-containing AMPA receptors |
| KEGG:05033 | 0.0012508225637 | 0.4 | GRIA4 GRIA3 | Nicotine addiction |
| REAC:R-HSA-438066 | 0.00206313859056 | 0.4 | GRIA4 GRIA3 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-8849932 | 0.00232071308473 | 0.4 | GRIA4 GRIA3 | Synaptic adhesion-like molecules |
| WP:WP2636 | 0.00290547066497 | 0.4 | GRIA4 GRIA3 | Common pathways underlying drug addiction |
| REAC:R-HSA-399721 | 0.00454605723789 | 0.4 | GRIA4 GRIA3 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| REAC:R-HSA-399719 | 0.00454605723789 | 0.4 | GRIA4 GRIA3 | Trafficking of AMPA receptors |
| KEGG:05031 | 0.00720037844657 | 0.4 | GRIA4 GRIA3 | Amphetamine addiction |
| WP:WP3584 | 0.010328593539 | 0.4 | GRIA4 GRIA3 | MECP2 and associated Rett syndrome |
| KEGG:04713 | 0.0118302702264 | 0.4 | GRIA4 GRIA3 | Circadian entrainment |
| KEGG:04724 | 0.0145692619713 | 0.4 | GRIA4 GRIA3 | Glutamatergic synapse |
| HP:0000322 | 0.0250797490255 | 0.6 | GRIA3 GRIA4 HECTD4 | Short philtrum |
| KEGG:04728 | 0.0263659307172 | 0.4 | GRIA4 GRIA3 | Dopaminergic synapse |
| GO:0004971 | 0.0280843539964 | 0.4 | GRIA4 GRIA3 | AMPA glutamate receptor activity |
| HP:0000400 | 0.0303400604109 | 0.6 | GRIA3 GRIA4 HECTD4 | Macrotia |
| KEGG:04723 | 0.0314069031448 | 0.4 | GRIA4 GRIA3 | Retrograde endocannabinoid signaling |
| WP:WP5083 | 0.035376376638 | 0.4 | GRIA4 GRIA3 | Neuroinflammation and glutamatergic signaling |
| REAC:R-HSA-6794362 | 0.0363707033179 | 0.4 | GRIA4 GRIA3 | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 0.0475253950332 | 0.4 | GRIA4 GRIA3 | Activation of NMDA receptors and postsynaptic events |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GRIA4 | GRIA3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GRIA3 | CCPG1 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CCPG1 | SLC22A13 | 0.902 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GRIA4 | CCPG1 | 0.265 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GRIA4 | huMAP3_00381.1 huMAP3_12440.1 huMAP3_13308.1 |
| HECTD4 | huMAP3_00381.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_11206.1 huMAP3_11737.1 huMAP3_12440.1 |
| CCPG1 | huMAP3_00824.1 huMAP3_10955.1 huMAP3_12440.1 huMAP3_14700.1 huMAP3_15126.1 |
| SLC22A13 | huMAP3_12440.1 huMAP3_14366.1 |
| GRIA3 | huMAP3_00381.1 huMAP3_12440.1 huMAP3_13308.1 |