hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12452.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| USP8 | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | 5 | UniProt NCBI |
| ZSCAN21 | Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38) | 5 | UniProt NCBI |
| BCR | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | 5 | UniProt NCBI |
| GAB2 | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | 5 | UniProt NCBI |
| BAZ2B | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | 5 | UniProt NCBI |
| GRAP2 | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | 5 | UniProt NCBI |
| PTPN23 | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | 5 | UniProt NCBI |
| GAB1 | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP437 | 0.00288515215021 | 0.428571428571 | USP8 GAB2 GAB1 | EGF EGFR signaling pathway |
| REAC:R-HSA-9006934 | 0.00475797272612 | 0.571428571429 | USP8 GAB2 GAB1 GRAP2 | Signaling by Receptor Tyrosine Kinases |
| WP:WP3676 | 0.00718724508234 | 0.285714285714 | GAB2 GAB1 | BDNF TrkB signaling |
| REAC:R-HSA-109704 | 0.0133002920771 | 0.285714285714 | GAB2 GAB1 | PI3K Cascade |
| REAC:R-HSA-9680350 | 0.0143201223364 | 0.285714285714 | GRAP2 GAB2 | Signaling by CSF1 (M-CSF) in myeloid cells |
| REAC:R-HSA-5655302 | 0.0153773615715 | 0.285714285714 | GAB2 GAB1 | Signaling by FGFR1 in disease |
| REAC:R-HSA-112399 | 0.0164719839916 | 0.285714285714 | GAB2 GAB1 | IRS-mediated signalling |
| REAC:R-HSA-8853659 | 0.0164719839916 | 0.285714285714 | GAB2 GAB1 | RET signaling |
| REAC:R-HSA-9607240 | 0.0187732752758 | 0.285714285714 | GRAP2 GAB2 | FLT3 Signaling |
| REAC:R-HSA-2428924 | 0.0199798926111 | 0.285714285714 | GAB2 GAB1 | IGF1R signaling cascade |
| REAC:R-HSA-2428928 | 0.0199798926111 | 0.285714285714 | GAB2 GAB1 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2404192 | 0.0199798926111 | 0.285714285714 | GAB2 GAB1 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-74751 | 0.0238233224402 | 0.285714285714 | GAB2 GAB1 | Insulin receptor signalling cascade |
| REAC:R-HSA-1433557 | 0.0238233224402 | 0.285714285714 | GRAP2 GAB2 | Signaling by SCF-KIT |
| WP:WP69 | 0.0321598473831 | 0.285714285714 | GRAP2 GAB2 | T cell receptor signaling pathway |
| REAC:R-HSA-1227986 | 0.0340922297215 | 0.285714285714 | USP8 GAB1 | Signaling by ERBB2 |
| REAC:R-HSA-1226099 | 0.0461752771557 | 0.285714285714 | GAB2 GAB1 | Signaling by FGFR in disease |
| REAC:R-HSA-2219530 | 0.0461752771557 | 0.285714285714 | GAB2 GAB1 | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP23 | 0.0499136541057 | 0.285714285714 | GAB2 GAB1 | B cell receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PTPN23 | GRAP2 | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GAB1 | GRAP2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GAB2 | GRAP2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GRAP2 | USP8 | 0.999 | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ZSCAN21 | GRAP2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GAB2 | USP8 | 0.98 | 0.178 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PTPN23 | USP8 | 0.966 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| BCR | GRAP2 | 0.962 | 0.124 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 bioplex_WMM |
| ZSCAN21 | USP8 | 0.948 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only |
| GAB1 | USP8 | 0.944 | 0.096 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| GAB2 | ZSCAN21 | 0.941 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
| GAB1 | ZSCAN21 | 0.939 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only |
| GAB2 | BCR | 0.935 | 0.334 | bioplex_WMM bioplex3_WMM boldt WMM_only boldt_WMM |
| GAB1 | BCR | 0.91 | 0.114 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PTPN23 | BAZ2B | 0.895 | 0.094 | hein_WMM hein () |
| PTPN23 | ZSCAN21 | 0.876 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| GAB2 | PTPN23 | 0.859 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| GAB2 | GAB1 | 0.855 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only |
| GAB1 | PTPN23 | 0.848 | 0.074 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PTPN23 | BCR | 0.821 | 0.138 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| BCR | USP8 | 0.29 | 0.062 | bioplex3_WMM boldt youn_WMM fraction boldt_WMM bioplex_WMM |
| USP8 | BAZ2B | 0.192 | 0.062 | hein_WMM WMM_only |
| ZSCAN21 | BCR | 0.155 | 0.034 | bioplex3_WMM WMM_only bioplex_WMM |
Related Complexes