hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12453.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LIX1L | LIX1-like protein | 2 | UniProt NCBI |
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | 4 | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | 5 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| CAST | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1474228 | 0.000261669015753 | 0.75 | CAST CAPN8 CAPNS1 | Degradation of the extracellular matrix |
| REAC:R-HSA-8862803 | 0.00214930898727 | 0.5 | CAST CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00214930898727 | 0.5 | CAST CAPNS1 | Neurodegenerative Diseases |
| REAC:R-HSA-1474244 | 0.00270393678592 | 0.75 | CAST CAPN8 CAPNS1 | Extracellular matrix organization |
| REAC:R-HSA-9734009 | 0.00282403231951 | 0.5 | CAST CAPNS1 | Defective Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-9645723 | 0.041644107744 | 0.5 | CAST CAPNS1 | Diseases of programmed cell death |
| CORUM:6710 | 0.049938562206 | 0.25 | CAPNS1 | Calpain 1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAST | CAPN8 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAST | CAPNS1 | 0.997 | 0.186 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CAPN2 | CAPNS1 | 0.987 | 0.336 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CAPN8 | CAPNS1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAST | LIX1L | 0.959 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
| CAST | CAPN2 | 0.707 | 0.142 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| LIX1L | CAPNS1 | 0.641 | 0.038 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CAPN8 | CAPN2 | 0.56 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LIX1L | CAPN2 | 0.101 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes