hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12473.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STX4 | Syntaxin-4 (Renal carcinoma antigen NY-REN-31) | 5 | UniProt NCBI |
| STXBP3 | Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) | 5 | UniProt NCBI |
| PLPPR4 | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | 5 | UniProt NCBI |
| PLPPR1 | Phospholipid phosphatase-related protein type 1 (Inactive 2-lysophosphatidate phosphatase PLPPR1) (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-114516 | 0.000102497642323 | 0.5 | STX4 STXBP3 | Disinhibition of SNARE formation |
| REAC:R-HSA-419408 | 0.000563428413222 | 0.5 | PLPPR4 PLPPR1 | Lysosphingolipid and LPA receptors |
| REAC:R-HSA-1445148 | 0.0239057396727 | 0.5 | STX4 STXBP3 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| WP:WP481 | 0.0255965717397 | 0.5 | STX4 STXBP3 | Insulin signaling |
| CORUM:730 | 0.049938562206 | 0.25 | STX4 | SNARE complex (STX4, SNAP23, VAMP1) |
| CORUM:733 | 0.049938562206 | 0.25 | STX4 | SNARE complex (STX4, VAMP1, VAMP7) |
| CORUM:805 | 0.049938562206 | 0.25 | STX4 | SNARE complex (STX4, SNAP23) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STX4 | STXBP3 | 0.997 | 0.922 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PLPPR4 | PLPPR1 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLPPR1 | STXBP3 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| STX4 | PLPPR1 | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| STX4 | PLPPR4 | 0.026 | 0.184 | bioplex3_WMM WMM_only |
| PLPPR4 | STXBP3 | 0.025 | 0.106 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| STX4 | huMAP3_00601.1 huMAP3_06458.1 huMAP3_08929.1 huMAP3_10587.1 huMAP3_12473.1 huMAP3_13160.1 |
| STXBP3 | huMAP3_12473.1 |
| PLPPR4 | huMAP3_02758.1 huMAP3_11281.1 huMAP3_12473.1 huMAP3_12802.1 |
| PLPPR1 | huMAP3_02758.1 huMAP3_11281.1 huMAP3_12473.1 huMAP3_12802.1 |