hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12476.1
Complex Portal: CPX-16096
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HPS1 | BLOC-3 complex member HPS1 (Hermansky-Pudlak syndrome 1 protein) | 5 | UniProt NCBI |
| WDPCP | WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein) | 5 | UniProt NCBI |
| INTU | Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) | 5 | UniProt NCBI |
| CPLANE2 | Ciliogenesis and planar polarity effector 2 (REM2- and Rab-like small GTPase 1) | 5 | UniProt NCBI |
| FUZ | Protein fuzzy homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0001736 | 0.000158467845213 | 0.6 | WDPCP INTU FUZ | establishment of planar polarity |
| GO:0007164 | 0.000158467845213 | 0.6 | WDPCP INTU FUZ | establishment of tissue polarity |
| WP:WP4536 | 0.000181875223355 | 0.6 | WDPCP FUZ CPLANE2 | Genes related to primary cilium development based on CRISPR |
| GO:0001738 | 0.00314081658857 | 0.6 | WDPCP INTU FUZ | morphogenesis of a polarized epithelium |
| HP:0001674 | 0.00422725674544 | 0.4 | WDPCP INTU | Complete atrioventricular canal defect |
| HP:0011802 | 0.0109419445801 | 0.4 | WDPCP INTU | Hamartoma of tongue |
| GO:0042073 | 0.0109904490822 | 0.6 | WDPCP INTU FUZ | intraciliary transport |
| GO:0021915 | 0.0155155487472 | 0.6 | WDPCP INTU FUZ | neural tube development |
| GO:0070925 | 0.0156623135541 | 1.0 | WDPCP FUZ CPLANE2 HPS1 INTU | organelle assembly |
| WP:WP5234 | 0.0165943234371 | 0.4 | WDPCP FUZ | Bardet Biedl syndrome |
| GO:1902017 | 0.0279690439474 | 0.6 | WDPCP INTU FUZ | regulation of cilium assembly |
| GO:0060271 | 0.029778729952 | 0.8 | WDPCP FUZ INTU CPLANE2 | cilium assembly |
| GO:0044782 | 0.0394877667138 | 0.8 | WDPCP FUZ INTU CPLANE2 | cilium organization |
| HP:0025033 | 0.0443303161429 | 0.8 | WDPCP FUZ HPS1 INTU | Abnormal digestive system morphology |
| HP:0100648 | 0.0448666137641 | 0.4 | WDPCP INTU | Neoplasm of the tongue |
| CORUM:241 | 0.0498708842806 | 0.2 | HPS1 | BLOC-3 (biogenesis of lysosome-related organelles complex 3) |
| CORUM:11 | 0.0498708842806 | 0.2 | HPS1 | BLOC-3 (biogenesis of lysosome-related organelles complex 3) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FUZ | CPLANE2 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| FUZ | INTU | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| FUZ | WDPCP | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| INTU | CPLANE2 | 0.994 |
structurally_consistent (Q9BT04)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| FUZ | HPS1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | ||
| WDPCP | CPLANE2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WDPCP | HPS1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WDPCP | INTU | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CPLANE2 | HPS1 | 0.504 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| INTU | HPS1 | 0.5 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
Related Complexes