hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12483.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRDX1 | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | 5 | UniProt NCBI |
| EEF2 | Elongation factor 2 (EF-2) (EC 3.6.5.-) | 5 | UniProt NCBI |
| KRTAP13-2 | Keratin-associated protein 13-2 | 5 | UniProt NCBI |
| PRDX2 | Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8862803 | 0.00143063482691 | 0.666666666667 | PRDX1 PRDX2 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00143063482691 | 0.666666666667 | PRDX1 PRDX2 | Neurodegenerative Diseases |
| REAC:R-HSA-9734009 | 0.00188000535098 | 0.666666666667 | PRDX1 PRDX2 | Defective Intrinsic Pathway for Apoptosis |
| WP:WP15 | 0.00257262049766 | 0.666666666667 | PRDX1 PRDX2 | Selenium micronutrient network |
| REAC:R-HSA-3299685 | 0.00257431960226 | 0.666666666667 | PRDX1 PRDX2 | Detoxification of Reactive Oxygen Species |
| GO:0008379 | 0.00842684400117 | 0.666666666667 | PRDX1 PRDX2 | thioredoxin peroxidase activity |
| GO:0051920 | 0.00842684400117 | 0.666666666667 | PRDX1 PRDX2 | peroxiredoxin activity |
| GO:0140824 | 0.00842684400117 | 0.666666666667 | PRDX1 PRDX2 | thioredoxin-dependent peroxiredoxin activity |
| REAC:R-HSA-5628897 | 0.0209338694285 | 0.666666666667 | PRDX1 PRDX2 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-9645723 | 0.0278082114556 | 0.666666666667 | PRDX1 PRDX2 | Diseases of programmed cell death |
| WP:WP4873 | 0.0496447587094 | 0.333333333333 | PRDX2 | Peroxiredoxin 2 induced ovarian failure |
| CORUM:3151 | 0.0499402709677 | 0.333333333333 | PRDX1 | Sulphiredoxin-peroxiredoxin complex |
| CORUM:6675 | 0.0499402709677 | 0.333333333333 | PRDX1 | PI4K2A-PRDX1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRDX1 | PRDX2 | 0.994 | 0.482 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| PRDX2 | KRTAP13-2 | 0.862 | bioplex3_HEK293 WMM_only boldt_WMM | |
| EEF2 | PRDX2 | 0.801 | 0.532 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF2 | PRDX1 | 0.217 | 0.787666666667 | bioplex_WMM bioplex3_WMM boldt WMM_only boldt_WMM treiber_WMM |
| EEF2 | KRTAP13-2 | 0.013 | bioplex3_HEK293 WMM_only boldt_WMM | |
| PRDX1 | KRTAP13-2 | 0.003 | bioplex3_HEK293 WMM_only boldt_WMM |
Related Complexes