hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12490.1
Complex Portal: CPX-15950
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HROB | Homologous recombination OB-fold protein | 5 | UniProt NCBI |
| RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | 5 | UniProt NCBI |
| FOXM1 | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | 5 | UniProt NCBI |
| RRM1 | Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) | 5 | UniProt NCBI |
| FBXO48 | F-box only protein 48 (F-box protein 48) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4584 | 0.000458099292948 | 0.4 | RRM2B RRM1 | Biomarkers for pyrimidine metabolism disorders |
| WP:WP4225 | 0.00089796435942 | 0.4 | RRM2B RRM1 | Pyrimidine metabolism and related diseases |
| REAC:R-HSA-499943 | 0.00383489202506 | 0.4 | RRM2B RRM1 | Interconversion of nucleotide di- and triphosphates |
| KEGG:00240 | 0.00447375439216 | 0.4 | RRM2B RRM1 | Pyrimidine metabolism |
| KEGG:00480 | 0.00553191318989 | 0.4 | RRM2B RRM1 | Glutathione metabolism |
| GO:0000731 | 0.00627040828674 | 0.6 | HROB RRM1 RRM2B | DNA synthesis involved in DNA repair |
| KEGG:00983 | 0.00996128881886 | 0.4 | RRM2B RRM1 | Drug metabolism - other enzymes |
| KEGG:01232 | 0.0108758996329 | 0.4 | RRM2B RRM1 | Nucleotide metabolism |
| GO:0004748 | 0.0140440992017 | 0.4 | RRM2B RRM1 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO:0061731 | 0.0140440992017 | 0.4 | RRM2B RRM1 | ribonucleoside-diphosphate reductase activity |
| GO:0005971 | 0.0140440992017 | 0.4 | RRM2B RRM1 | ribonucleoside-diphosphate reductase complex |
| KEGG:00230 | 0.0213229262457 | 0.4 | RRM2B RRM1 | Purine metabolism |
| GO:0070318 | 0.0280843539964 | 0.4 | RRM2B RRM1 | positive regulation of G0 to G1 transition |
| REAC:R-HSA-15869 | 0.0440242300692 | 0.4 | RRM2B RRM1 | Metabolism of nucleotides |
| GO:0016728 | 0.0468008499735 | 0.4 | RRM2B RRM1 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RRM2B | RRM1 | 0.979 | 0.082 |
mutually_exclusive (P31350)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RRM1 | FBXO48 | 0.972 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RRM1 | HROB | 0.958 | 0.086 | hein_WMM bioplex3_WMM WMM_only | |
| FOXM1 | RRM1 | 0.929 | 0.1495 | hein_WMM bioplex3_WMM WMM_only | |
| RRM2B | FBXO48 | 0.502 |
mutually_exclusive (P23921)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| FOXM1 | HROB | 0.095 | 0.064 | bioplex3_WMM WMM_only | |
| RRM2B | HROB | 0.027 | 0.026 | bioplex3_WMM WMM_only |
Related Complexes