hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12491.1
Complex Portal: CPX-25196
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG16L2 | Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) | 4 | UniProt NCBI |
| RAB33A | Ras-related protein Rab-33A (Small GTP-binding protein S10) | 5 | UniProt NCBI |
| ATG16L1 | Autophagy-related protein 16-1 (APG16-like 1) | 5 | UniProt NCBI |
| SWSAP1 | ATPase SWSAP1 (SWIM-type zinc finger 7-associated protein 1) (SWS1-associated protein 1) (ZSWIM7-associated protein 1) (ZSWIM7AP1) | 5 | UniProt NCBI |
| ZSWIM7 | Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog) (SWIM-type zinc finger domain-containing protein 7) | 5 | UniProt NCBI |
| RAB33B | Ras-related protein Rab-33B | 5 | UniProt NCBI |
| ATG12 | Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) | 5 | UniProt NCBI |
| TECPR1 | Tectonin beta-propeller repeat-containing protein 1 | 5 | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | 5 | UniProt NCBI |
| RAB19 | Ras-related protein Rab-19 | 4 | UniProt NCBI |
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | 5 | UniProt NCBI |
| SPIDR | DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0034274 | 4.27717811223e-11 | 0.416666666667 | ATG12 ATG5 ATG16L2 ATG3 ATG16L1 | Atg12-Atg5-Atg16 complex |
| WP:WP4863 | 1.42023401696e-10 | 0.416666666667 | ATG12 ATG5 ATG16L2 ATG3 ATG16L1 | Host pathogen interaction of human coronaviruses autophagy |
| KEGG:04140 | 6.11760717814e-08 | 0.5 | ATG3 RAB33B ATG16L2 ATG5 ATG12 ATG16L1 | Autophagy - animal |
| WP:WP2509 | 2.20858427002e-07 | 0.333333333333 | ATG12 ATG16L1 ATG3 ATG5 | Nanoparticle triggered autophagic cell death |
| KEGG:04136 | 3.66838312054e-07 | 0.333333333333 | ATG12 ATG16L1 ATG3 ATG5 | Autophagy - other |
| WP:WP4923 | 6.16568031302e-07 | 0.333333333333 | ATG12 ATG16L1 ATG3 ATG5 | Autophagy |
| GO:0000407 | 1.42069743999e-06 | 0.416666666667 | ATG12 ATG5 ATG16L2 ATG3 ATG16L1 | phagophore assembly site |
| WP:WP4577 | 2.73759922944e-06 | 0.333333333333 | ATG12 ATG16L1 ATG3 ATG5 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| GO:0000045 | 3.06856448493e-06 | 0.5 | RAB19 ATG3 ATG16L2 ATG5 ATG12 ATG16L1 | autophagosome assembly |
| GO:1905037 | 3.94015794418e-06 | 0.5 | RAB19 ATG3 ATG16L2 ATG5 ATG12 ATG16L1 | autophagosome organization |
| GO:0034045 | 1.76932944819e-05 | 0.333333333333 | ATG12 ATG5 ATG16L2 ATG16L1 | phagophore assembly site membrane |
| WP:WP5205 | 2.40970046401e-05 | 0.333333333333 | ATG12 ATG16L1 ATG3 ATG5 | Clock controlled autophagy in bone metabolism |
| GO:0016236 | 2.68737083232e-05 | 0.583333333333 | RAB19 ATG3 ATG16L2 TECPR1 ATG5 ATG12 ATG16L1 | macroautophagy |
| GO:0005776 | 0.000128063657473 | 0.416666666667 | TECPR1 ATG12 ATG5 ATG16L2 ATG16L1 | autophagosome |
| GO:0007033 | 0.000144252090564 | 0.5 | RAB19 ATG3 ATG16L2 ATG5 ATG12 ATG16L1 | vacuole organization |
| REAC:R-HSA-1632852 | 0.000671552380622 | 0.333333333333 | ATG12 ATG16L1 ATG3 ATG5 | Macroautophagy |
| GO:0061919 | 0.000828749731046 | 0.583333333333 | RAB19 ATG3 ATG16L2 TECPR1 ATG5 ATG12 ATG16L1 | process utilizing autophagic mechanism |
| GO:0006914 | 0.000828749731046 | 0.583333333333 | RAB19 ATG3 ATG16L2 TECPR1 ATG5 ATG12 ATG16L1 | autophagy |
| REAC:R-HSA-9612973 | 0.00105158696648 | 0.333333333333 | ATG12 ATG16L1 ATG3 ATG5 | Autophagy |
| KEGG:05131 | 0.00132231337546 | 0.333333333333 | ATG12 ATG5 ATG16L1 TECPR1 | Shigellosis |
| REAC:R-HSA-8873719 | 0.00422953591034 | 0.25 | RAB33A RAB33B RAB19 | RAB geranylgeranylation |
| REAC:R-HSA-8934903 | 0.00468950688317 | 0.166666666667 | ATG12 ATG5 | Receptor Mediated Mitophagy |
| WP:WP5420 | 0.0051345793833 | 0.333333333333 | ATG12 ATG16L1 ATG3 ATG5 | ADHD and autism ASD linked metabolic pathways and SNP |
| KEGG:04621 | 0.0104532139401 | 0.25 | ATG12 ATG16L1 ATG5 | NOD-like receptor signaling pathway |
| GO:1901096 | 0.0117710605412 | 0.25 | ATG12 ATG5 TECPR1 | regulation of autophagosome maturation |
| GO:0044804 | 0.0142868257683 | 0.25 | ATG12 ATG5 ATG3 | nucleophagy |
| GO:0039689 | 0.0309012475255 | 0.166666666667 | ATG16L2 ATG16L1 | negative stranded viral RNA replication |
| GO:0097196 | 0.0309012475255 | 0.166666666667 | SWSAP1 ZSWIM7 | Shu complex |
| GO:0019776 | 0.0309012475255 | 0.166666666667 | ATG3 ATG5 | Atg8-family ligase activity |
| REAC:R-HSA-5205685 | 0.0349632924576 | 0.166666666667 | ATG12 ATG5 | PINK1-PRKN Mediated Mitophagy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATG5 | ATG16L1 | 1.0 | 0.128 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SWSAP1 | ZSWIM7 | 1.0 |
mutually_exclusive (Q9H082)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ATG5 | RAB33A | 0.999 | 0.178 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | TECPR1 | 0.999 | 0.09 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | ATG12 | 0.999 | 0.442 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| RAB33B | ATG5 | 0.999 | 0.14 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAB33A | ATG16L1 | 0.999 | 0.064 |
mutually_exclusive (Q9H082)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAB33B | RAB33A | 0.998 | 0.106 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG12 | RAB33A | 0.998 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATG16L2 | ATG5 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB33B | ATG16L1 | 0.998 | 0.0448888888889 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAB33B | ATG12 | 0.998 | 0.118 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG12 | ATG3 | 0.998 | 0.23475 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPIDR | SWSAP1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SWSAP1 | RAB33B | 0.996 |
mutually_exclusive (Q19AV6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZSWIM7 | RAB33B | 0.993 |
mutually_exclusive (Q6NVH7)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB33A | RAB19 | 0.988 | 0.044 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATG12 | ATG16L1 | 0.986 | 0.162761904762 |
mutually_exclusive (Q9H082)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SPIDR | ZSWIM7 | 0.984 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| ATG5 | ATG3 | 0.984 | 0.072 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ATG16L2 | TECPR1 | 0.946 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| ATG3 | ATG16L1 | 0.942 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SWSAP1 | RAB33A | 0.924 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| TECPR1 | ATG16L1 | 0.916 | 0.056 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only |
| ATG16L2 | ATG16L1 | 0.916 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| ZSWIM7 | RAB33A | 0.902 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ATG16L2 | ATG12 | 0.779 |
structurally_consistent (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| ATG12 | TECPR1 | 0.779 | 0.134 | bioplex3_WMM WMM_only | |
| SWSAP1 | ATG16L1 | 0.467 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| SWSAP1 | ATG5 | 0.431 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ZSWIM7 | ATG12 | 0.401 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| SWSAP1 | ATG12 | 0.389 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ZSWIM7 | ATG16L1 | 0.356 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ZSWIM7 | ATG5 | 0.356 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ATG12 | RAB19 | 0.278 | 0.17 |
structurally_consistent (Q9H082)
|
bioplex3_WMM WMM_only |
| RAB33B | RAB19 | 0.25 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| ATG16L1 | RAB19 | 0.25 | 0.066 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only |
| ATG5 | RAB19 | 0.25 | 0.124 | bioplex3_WMM WMM_only |
Related Complexes