hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12503.1
Complex Portal: CPX-24433
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FOXN2 | Forkhead box protein N2 (Human T-cell leukemia virus enhancer factor) | 4 | UniProt NCBI |
| FOXJ1 | Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4) | 5 | UniProt NCBI |
| CFAP20 | Cilia- and flagella-associated protein 20 (Basal body up-regulated protein 22) (Transcription factor IIB) | 5 | UniProt NCBI |
| FBXL3 | F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A) | 5 | UniProt NCBI |
| RFX1 | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | 5 | UniProt NCBI |
| FAM149B1 | Primary cilium assembly protein FAM149B1 | 4 | UniProt NCBI |
| YAE1 | Protein YAE1 homolog (Yae1 domain-containing protein 1) | 4 | UniProt NCBI |
| RFX3 | Transcription factor RFX3 (Regulatory factor X 3) | 5 | UniProt NCBI |
| CDK20 | Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42) | 5 | UniProt NCBI |
| TBC1D32 | Protein broad-minded (TBC1 domain family member 32) | 5 | UniProt NCBI |
| RFX2 | DNA-binding protein RFX2 (Regulatory factor X 2) | 5 | UniProt NCBI |
| LTO1 | Protein LTO1 homolog (Oral cancer-overexpressed protein 1) (Tumor-amplified and overexpressed sequence 1) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0060271 | 0.000877880583039 | 0.545454545455 | FOXJ1 RFX3 CFAP20 TBC1D32 FAM149B1 RFX2 | cilium assembly |
| GO:0044782 | 0.00133680362501 | 0.545454545455 | FOXJ1 RFX3 CFAP20 TBC1D32 FAM149B1 RFX2 | cilium organization |
| GO:0120031 | 0.00857707520497 | 0.545454545455 | FOXJ1 RFX3 CFAP20 TBC1D32 FAM149B1 RFX2 | plasma membrane bounded cell projection assembly |
| GO:0030031 | 0.00991884023273 | 0.545454545455 | FOXJ1 RFX3 CFAP20 TBC1D32 FAM149B1 RFX2 | cell projection assembly |
| WP:WP5202 | 0.0263384546088 | 0.181818181818 | RFX3 RFX2 | Alstrom syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CFAP20 | TBC1D32 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| CDK20 | CFAP20 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| TBC1D32 | FOXJ1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| FOXJ1 | RFX3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| RFX1 | FOXJ1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| CDK20 | FOXJ1 | 0.999 |
mutually_exclusive (Q9Y6A4)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| RFX2 | FOXJ1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | ||
| RFX1 | RFX2 | 0.998 |
mutually_exclusive (P48380)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| CDK20 | TBC1D32 | 0.997 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| RFX2 | RFX3 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only | |
| CFAP20 | FOXJ1 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| RFX1 | RFX3 | 0.995 | 0.298 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| RFX1 | FOXN2 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | ||
| FAM149B1 | TBC1D32 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | ||
| RFX2 | FOXN2 | 0.95 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CFAP20 | FAM149B1 | 0.943 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| RFX3 | YAE1 | 0.893 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RFX2 | FBXL3 | 0.846 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RFX1 | FBXL3 | 0.84 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| FOXJ1 | YAE1 | 0.839 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| YAE1 | LTO1 | 0.802 | 0.178 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RFX1 | TBC1D32 | 0.709 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| CDK20 | RFX2 | 0.68 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| CFAP20 | RFX2 | 0.675 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| TBC1D32 | RFX3 | 0.66 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| RFX2 | TBC1D32 | 0.628 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| CFAP20 | RFX3 | 0.625 | 0.036 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| CDK20 | RFX3 | 0.609 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| CDK20 | RFX1 | 0.555 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| CFAP20 | RFX1 | 0.476 | 0.106 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| TBC1D32 | YAE1 | 0.203 | bioplex3_WMM WMM_only | ||
| CDK20 | FAM149B1 | 0.198 |
mutually_exclusive (Q9Y6A4)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| CDK20 | YAE1 | 0.165 | bioplex3_WMM WMM_only | ||
| RFX2 | YAE1 | 0.116 | bioplex3_WMM WMM_only | ||
| RFX1 | YAE1 | 0.094 | 0.024 | bioplex3_WMM WMM_only | |
| CFAP20 | YAE1 | 0.042 | 0.124 | bioplex3_WMM WMM_only | |
| RFX3 | FOXN2 | 0.034 | WMM_only boldt_WMM | ||
| CDK20 | FBXL3 | 0.019 | bioplex3_WMM WMM_only | ||
| FOXN2 | YAE1 | 0.017 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| CFAP20 | FOXN2 | 0.01 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| FAM149B1 | YAE1 | 0.006 | bioplex3_HEK293 bioplex () | ||
| FBXL3 | YAE1 | 0.001 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes