hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12505.1
Complex Portal: CPX-17531
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALDOA | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | 5 | UniProt NCBI |
| RDX | Radixin | 5 | UniProt NCBI |
| ALDOB | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | 5 | UniProt NCBI |
| ALDOC | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | 5 | UniProt NCBI |
| TREML1 | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004332 | 9.61200410764e-07 | 0.6 | ALDOB ALDOA ALDOC | fructose-bisphosphate aldolase activity |
| KEGG:00030 | 2.72290171157e-06 | 0.6 | ALDOB ALDOA ALDOC | Pentose phosphate pathway |
| KEGG:00051 | 5.56653803159e-06 | 0.6 | ALDOB ALDOA ALDOC | Fructose and mannose metabolism |
| REAC:R-HSA-70263 | 9.10580767182e-06 | 0.6 | ALDOB ALDOA ALDOC | Gluconeogenesis |
| WP:WP534 | 1.3807096837e-05 | 0.6 | ALDOB ALDOA ALDOC | Glycolysis and gluconeogenesis |
| GO:0016832 | 1.92180881975e-05 | 0.6 | ALDOB ALDOA ALDOC | aldehyde-lyase activity |
| KEGG:00010 | 3.50803627136e-05 | 0.6 | ALDOB ALDOA ALDOC | Glycolysis / Gluconeogenesis |
| KEGG:01230 | 4.44119474406e-05 | 0.6 | ALDOB ALDOA ALDOC | Biosynthesis of amino acids |
| HP:0012545 | 6.41370849429e-05 | 0.4 | ALDOB ALDOA | Reduced circulating aldolase concentration |
| GO:0030388 | 8.06911104389e-05 | 0.6 | ALDOB ALDOA ALDOC | fructose 1,6-bisphosphate metabolic process |
| GO:0006000 | 8.06911104389e-05 | 0.6 | ALDOB ALDOA ALDOC | fructose metabolic process |
| WP:WP4018 | 8.09375187038e-05 | 0.6 | ALDOB ALDOA ALDOC | Clear cell renal cell carcinoma pathways |
| WP:WP5355 | 0.000122528877875 | 0.6 | ALDOB ALDOA ALDOC | Metabolic Epileptic Disorders |
| REAC:R-HSA-70171 | 0.00013544954428 | 0.6 | ALDOB ALDOA ALDOC | Glycolysis |
| KEGG:04066 | 0.00014493342506 | 0.6 | ALDOB ALDOA ALDOC | HIF-1 signaling pathway |
| KEGG:01200 | 0.000168183083601 | 0.6 | ALDOB ALDOA ALDOC | Carbon metabolism |
| REAC:R-HSA-70326 | 0.000244866764891 | 0.6 | ALDOB ALDOA ALDOC | Glucose metabolism |
| GO:0016830 | 0.00627040828674 | 0.6 | ALDOB ALDOA ALDOC | carbon-carbon lyase activity |
| REAC:R-HSA-71387 | 0.00840189510813 | 0.6 | ALDOB ALDOA ALDOC | Metabolism of carbohydrates |
| HP:0012400 | 0.0176485923371 | 0.4 | ALDOB ALDOA | Abnormal circulating aldolase concentration |
| GO:0006096 | 0.0417184596383 | 0.6 | ALDOB ALDOA ALDOC | glycolytic process |
| GO:0046032 | 0.0417184596383 | 0.6 | ALDOB ALDOA ALDOC | ADP catabolic process |
| GO:0046031 | 0.0437005530348 | 0.6 | ALDOB ALDOA ALDOC | ADP metabolic process |
| GO:0009137 | 0.0457443058639 | 0.6 | ALDOB ALDOA ALDOC | purine nucleoside diphosphate catabolic process |
| GO:0009181 | 0.0457443058639 | 0.6 | ALDOB ALDOA ALDOC | purine ribonucleoside diphosphate catabolic process |
| GO:0019364 | 0.0478506537833 | 0.6 | ALDOB ALDOA ALDOC | pyridine nucleotide catabolic process |
| GO:0009179 | 0.0478506537833 | 0.6 | ALDOB ALDOA ALDOC | purine ribonucleoside diphosphate metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ALDOC | ALDOA | 0.999 | 0.78 |
mutually_exclusive (P05062)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction treiber_WMM |
| ALDOB | TREML1 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ALDOA | ALDOB | 0.994 | 0.298 |
mutually_exclusive (P09972)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ALDOC | ALDOB | 0.987 | 0.174 |
mutually_exclusive (P04075)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only |
| TREML1 | RDX | 0.978 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ALDOB | RDX | 0.919 | 0.111115789474 | Guru bioplex3_WMM fraction | |
| ALDOC | RDX | 0.027 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only | |
| ALDOC | TREML1 | 0.003 | bioplex3_HCT116 WMM_only | ||
| ALDOA | TREML1 | 0.003 | bioplex3_HCT116 WMM_only | ||
| ALDOA | RDX | 0.002 | 0.346 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| ALDOA | huMAP3_01143.1 huMAP3_04317.1 huMAP3_12505.1 |
| RDX | huMAP3_04321.1 huMAP3_10281.1 huMAP3_12505.1 |
| ALDOB | huMAP3_01143.1 huMAP3_04317.1 huMAP3_06225.1 huMAP3_12505.1 |
| ALDOC | huMAP3_01143.1 huMAP3_04317.1 huMAP3_12505.1 |
| TREML1 | huMAP3_04317.1 huMAP3_06225.1 huMAP3_12505.1 |