hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12513.1

Complex Portal: CPX-10623

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RNF113A	E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183)	5	UniProt NCBI
TAB1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)	5	UniProt NCBI
DCANP1	Dendritic cell nuclear protein 1 (Dendritic cell nuclear protein-1) (Dendritic cell-associated nuclear protein)	5	UniProt NCBI
CARNMT1	Carnosine N-methyltransferase (EC 2.1.1.22)	5	UniProt NCBI
TAB3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)	5	UniProt NCBI
ZBTB25	Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP)	5	UniProt NCBI
ZBTB2	Zinc finger and BTB domain-containing protein 2	5	UniProt NCBI
LENG9	Leukocyte receptor cluster member 9	2	UniProt NCBI
NR3C2	Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)	5	UniProt NCBI
TAB2	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)	5	UniProt NCBI
SFTPD	Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)	5	UniProt NCBI
ANGPTL2	Angiopoietin-related protein 2 (Angiopoietin-like protein 2)	4	UniProt NCBI
MAP3K7	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5268	1.47680123646e-09	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TNF-alpha/NF-kappa B signaling complex 7
REAC:R-HSA-937042	2.15255382745e-08	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	IRAK2 mediated activation of TAK1 complex
CORUM:2758	3.08880131998e-08	0.230769230769	MAP3K7 TAB1 TAB2	TAK1 complex
REAC:R-HSA-9645460	3.38091735304e-08	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Alpha-protein kinase 1 signaling pathway
REAC:R-HSA-9014325	3.38091735304e-08	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TICAM1,TRAF6-dependent induction of TAK1 complex
REAC:R-HSA-975163	7.31810120121e-08	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
REAC:R-HSA-937072	7.31810120121e-08	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TRAF6-mediated induction of TAK1 complex within TLR4 complex
REAC:R-HSA-450321	2.43115552171e-07	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REAC:R-HSA-450302	4.94182139826e-07	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	activated TAK1 mediates p38 MAPK activation
REAC:R-HSA-5357956	3.64621407237e-06	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TNFR1-induced NF-kappa-B signaling pathway
REAC:R-HSA-168638	3.64621407237e-06	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	NOD1/2 Signaling Pathway
REAC:R-HSA-168179	3.91294738344e-06	0.384615384615	SFTPD TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor TLR1:TLR2 Cascade
REAC:R-HSA-181438	3.91294738344e-06	0.384615384615	SFTPD TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor 2 (TLR2) Cascade
WP:WP2637	5.32135966327e-06	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Interleukin 1 IL 1 structural pathway
REAC:R-HSA-445989	5.9609772212e-06	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TAK1-dependent IKK and NF-kappa-B activation
REAC:R-HSA-9705671	8.08954048455e-06	0.384615384615	SFTPD TAB3 TAB1 MAP3K7 TAB2	SARS-CoV-2 activates/modulates innate and adaptive immune responses
WP:WP195	8.36948121767e-06	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	IL 1 signaling pathway
CORUM:6344	1.11799131849e-05	0.230769230769	MAP3K7 TAB1 TAB2	TNF-R1-associated signaling complex
REAC:R-HSA-166016	1.2963637311e-05	0.384615384615	SFTPD TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor 4 (TLR4) Cascade
REAC:R-HSA-168643	1.64324396853e-05	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REAC:R-HSA-168898	2.66495401148e-05	0.384615384615	SFTPD TAB3 TAB1 MAP3K7 TAB2	Toll-like Receptor Cascades
REAC:R-HSA-75893	2.93852273646e-05	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TNF signaling
KEGG:04064	3.27913224548e-05	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	NF-kappa B signaling pathway
REAC:R-HSA-450294	3.68032900595e-05	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	MAP kinase activation
REAC:R-HSA-448424	5.5731938401e-05	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Interleukin-17 signaling
KEGG:04668	6.55176163474e-05	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TNF signaling pathway
WP:WP75	7.76867844289e-05	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Toll like receptor signaling pathway
WP:WP231	8.15308114007e-05	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TNF alpha signaling pathway
REAC:R-HSA-9705683	0.000108013419213	0.384615384615	SFTPD TAB3 TAB1 MAP3K7 TAB2	SARS-CoV-2-host interactions
REAC:R-HSA-2871837	0.000120653069815	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	FCERI mediated NF-kB activation
CORUM:5215	0.00012303818858	0.153846153846	TAB1 TAB2	CS-MAP3K7IP1-MAP3K7IP2 complex
WP:WP3851	0.000146068861042	0.230769230769	MAP3K7 TAB1 TAB2	TLR4 signaling and tolerance
REAC:R-HSA-975871	0.000173022863985	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	MyD88 cascade initiated on plasma membrane
REAC:R-HSA-168142	0.000173022863985	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor 10 (TLR10) Cascade
REAC:R-HSA-168176	0.000173022863985	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor 5 (TLR5) Cascade
KEGG:04936	0.000190316417962	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Alcoholic liver disease
REAC:R-HSA-975138	0.000190684083495	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REAC:R-HSA-975155	0.000200001688642	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	MyD88 dependent cascade initiated on endosome
REAC:R-HSA-168181	0.000200001688642	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor 7/8 (TLR7/8) Cascade
REAC:R-HSA-168138	0.000240699428061	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor 9 (TLR9) Cascade
REAC:R-HSA-5607764	0.000251770237447	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	CLEC7A (Dectin-1) signaling
REAC:R-HSA-168164	0.00026321570263	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor 3 (TLR3) Cascade
WP:WP4329	0.000284590900854	0.230769230769	MAP3K7 TAB1 TAB2	miRNA role in immune response in sepsis
REAC:R-HSA-166166	0.000287263467526	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	MyD88-independent TLR4 cascade
REAC:R-HSA-937061	0.000287263467526	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	TRIF(TICAM1)-mediated TLR4 signaling
REAC:R-HSA-168188	0.000312909271517	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Toll Like Receptor TLR6:TLR2 Cascade
REAC:R-HSA-166058	0.000312909271517	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
KEGG:04621	0.000364495244631	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	NOD-like receptor signaling pathway
REAC:R-HSA-9020702	0.000369267675598	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Interleukin-1 signaling
REAC:R-HSA-2454202	0.00058401607439	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Fc epsilon receptor (FCERI) signaling
KEGG:05130	0.000591852287469	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Pathogenic Escherichia coli infection
REAC:R-HSA-9694516	0.000681978073925	0.384615384615	SFTPD TAB3 TAB1 MAP3K7 TAB2	SARS-CoV-2 Infection
REAC:R-HSA-5621481	0.000797481461609	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	C-type lectin receptors (CLRs)
WP:WP2018	0.000953709572131	0.230769230769	MAP3K7 TAB1 TAB2	RANKL RANK signaling pathway
REAC:R-HSA-73887	0.000999828572264	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Death Receptor Signaling
REAC:R-HSA-446652	0.00106405351904	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Interleukin-1 family signaling
KEGG:05140	0.00115405641457	0.230769230769	MAP3K7 TAB1 TAB2	Leishmaniasis
KEGG:05132	0.00197135143974	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Salmonella infection
KEGG:05131	0.00207674613549	0.307692307692	TAB3 TAB1 MAP3K7 TAB2	Shigellosis
KEGG:04657	0.00221498510963	0.230769230769	TAB3 TAB2 MAP3K7	IL-17 signaling pathway
KEGG:04620	0.00319307127413	0.230769230769	MAP3K7 TAB1 TAB2	Toll-like receptor signaling pathway
REAC:R-HSA-9679506	0.00325522184439	0.384615384615	SFTPD TAB3 TAB1 MAP3K7 TAB2	SARS-CoV Infections
KEGG:05145	0.00365218247642	0.230769230769	MAP3K7 TAB1 TAB2	Toxoplasmosis
KEGG:05135	0.00733158154625	0.230769230769	MAP3K7 TAB1 TAB2	Yersinia infection
KEGG:04380	0.00733158154625	0.230769230769	MAP3K7 TAB1 TAB2	Osteoclast differentiation
KEGG:05161	0.0154550895581	0.230769230769	MAP3K7 TAB1 TAB2	Hepatitis B
WP:WP4666	0.0251339083577	0.230769230769	MAP3K7 TAB1 TAB2	Hepatitis B infection
GO:0038061	0.0258736341179	0.307692307692	TAB3 TAB2 MAP3K7 NR3C2	non-canonical NF-kappaB signal transduction
KEGG:05169	0.0274490471376	0.230769230769	MAP3K7 TAB1 TAB2	Epstein-Barr virus infection
KEGG:05417	0.0274490471376	0.230769230769	MAP3K7 TAB1 TAB2	Lipid and atherosclerosis
KEGG:05170	0.0336484057102	0.230769230769	MAP3K7 TAB1 TAB2	Human immunodeficiency virus 1 infection
WP:WP4496	0.0365989932385	0.153846153846	MAP3K7 TAB1	Signal transduction through IL1R

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TAB1	TAB2	0.999	0.156		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
TAB1	MAP3K7	0.999	0.266		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only
CARNMT1	RNF113A	0.999	0.086		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TAB1	TAB3	0.998	0.172		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CARNMT1	ZBTB25	0.998	0.178	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ZBTB2	ZBTB25	0.998	0.068	mutually_exclusive (Q8N4J0)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
LENG9	CARNMT1	0.998	0.076	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SFTPD	RNF113A	0.997			bioplex3_WMM bioplex3_HCT116 WMM_only
CARNMT1	ZBTB2	0.985	0.072	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TAB2	MAP3K7	0.982	0.428	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
CARNMT1	MAP3K7	0.977	0.074	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ZBTB25	MAP3K7	0.974	0.108	mutually_exclusive (Q8N4J0)	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
CARNMT1	NR3C2	0.973			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ZBTB25	RNF113A	0.938	0.104		bioplex_WMM bioplex3_WMM WMM_only
CARNMT1	TAB2	0.933	0.07	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ZBTB2	ANGPTL2	0.929	0.06		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
LENG9	ZBTB25	0.914	0.064	mutually_exclusive (Q8N4J0)	bioplex_WMM bioplex3_WMM WMM_only
LENG9	RNF113A	0.907	0.136		bioplex_WMM bioplex3_WMM WMM_only
CARNMT1	DCANP1	0.904			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ZBTB2	RNF113A	0.875	0.104		bioplex_WMM bioplex3_WMM WMM_only
TAB3	TAB2	0.865	0.118	mutually_exclusive (O43318)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
LENG9	MAP3K7	0.855	0.106		bioplex_WMM bioplex3_WMM WMM_only
TAB3	MAP3K7	0.848	0.142	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CARNMT1	TAB1	0.846	0.054	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MAP3K7	RNF113A	0.789	0.142		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
LENG9	TAB1	0.655	0.157	mutually_exclusive (Q8N4J0)	bioplex_WMM bioplex3_WMM WMM_only
CARNMT1	SFTPD	0.626			bioplex3_WMM WMM_only
ZBTB25	TAB1	0.532	0.05	mutually_exclusive (Q8N4J0)	bioplex_WMM bioplex3_WMM WMM_only
LENG9	ZBTB2	0.407	0.11	mutually_exclusive (Q8N4J0)	bioplex_WMM bioplex3_WMM WMM_only
LENG9	NR3C2	0.391			bioplex_WMM bioplex3_WMM WMM_only
TAB1	RNF113A	0.389	0.16		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
NR3C2	RNF113A	0.378			bioplex_WMM bioplex3_WMM WMM_only
NR3C2	ZBTB25	0.378			bioplex_WMM bioplex3_WMM WMM_only
NR3C2	MAP3K7	0.242			bioplex_WMM bioplex3_WMM WMM_only
ZBTB25	TAB2	0.242	0.096	mutually_exclusive (Q8N4J0)	bioplex_WMM bioplex3_WMM WMM_only
NR3C2	TAB2	0.215			bioplex_WMM bioplex3_WMM WMM_only
LENG9	TAB2	0.215	0.12		bioplex_WMM bioplex3_WMM WMM_only
NR3C2	ZBTB2	0.215			bioplex_WMM bioplex3_WMM WMM_only
ZBTB2	MAP3K7	0.184	0.098		bioplex_WMM bioplex3_WMM WMM_only
NR3C2	TAB1	0.164			bioplex_WMM bioplex3_WMM WMM_only
TAB2	RNF113A	0.096	0.126		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ZBTB2	TAB1	0.067	0.094	mutually_exclusive (Q8N4J0)	bioplex_WMM bioplex3_WMM WMM_only
ZBTB2	TAB2	0.067	0.072	mutually_exclusive (Q8N4J0)	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
RNF113A	huMAP3_03631.1 huMAP3_07437.1 huMAP3_12513.1 huMAP3_13193.1
TAB1	huMAP3_01078.1 huMAP3_05292.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_12717.1 huMAP3_13193.1
DCANP1	huMAP3_11701.1 huMAP3_11715.1 huMAP3_11831.1 huMAP3_12513.1 huMAP3_13193.1
CARNMT1	huMAP3_00240.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_13193.1
TAB3	huMAP3_01078.1 huMAP3_05292.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_12717.1 huMAP3_13193.1
ZBTB25	huMAP3_00766.1 huMAP3_09540.1 huMAP3_11045.1 huMAP3_11701.1 huMAP3_11965.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_12513.1 huMAP3_13193.1 huMAP3_13361.1 huMAP3_13514.1 huMAP3_14353.1 huMAP3_14650.1
ZBTB2	huMAP3_00766.1 huMAP3_04896.1 huMAP3_06728.1 huMAP3_08906.1 huMAP3_09164.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_11045.1 huMAP3_12513.1 huMAP3_15128.1
LENG9	huMAP3_00240.1 huMAP3_03722.1 huMAP3_04227.1 huMAP3_04570.1 huMAP3_05547.1 huMAP3_08396.1 huMAP3_08414.1 huMAP3_10390.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_13193.1
NR3C2	huMAP3_00240.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_13193.1
TAB2	huMAP3_01078.1 huMAP3_05292.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_12717.1 huMAP3_13193.1
SFTPD	huMAP3_03631.1 huMAP3_07437.1 huMAP3_12513.1 huMAP3_13193.1
ANGPTL2	huMAP3_12513.1
MAP3K7	huMAP3_01078.1 huMAP3_05292.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_12717.1 huMAP3_13193.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12513.1

Complex Portal: CPX-10623