hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12518.1
Complex Portal: CPX-11788
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| REG4 | Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV) | 5 | UniProt NCBI |
| NMB | Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B] | 5 | UniProt NCBI |
| PLA2G2D | Group IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog) | 5 | UniProt NCBI |
| RNF123 | E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) | 5 | UniProt NCBI |
| DEFB125 | Beta-defensin 125 (Beta-defensin 25) (DEFB-25) (Defensin, beta 125) | 3 | UniProt NCBI |
| PNPLA1 | Omega-hydroxyceramide transacylase (EC 2.3.1.296) (Patatin-like phospholipase domain-containing protein 1) | 5 | UniProt NCBI |
| UBAC1 | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:386 | 2.05265451394e-05 | 0.285714285714 | RNF123 UBAC1 | Ubiquitin E3 ligase (UBADC1, RNF123) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF123 | UBAC1 | 0.999 | 0.144 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NMB | UBAC1 | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NMB | RNF123 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBAC1 | PNPLA1 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RNF123 | PNPLA1 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NMB | PLA2G2D | 0.947 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UBAC1 | DEFB125 | 0.909 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| REG4 | UBAC1 | 0.857 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| REG4 | RNF123 | 0.81 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RNF123 | DEFB125 | 0.713 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RNF123 | PLA2G2D | 0.141 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UBAC1 | PLA2G2D | 0.088 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes