hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12523.1

Complex Portal: CPX-10688

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
GTF2B	Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II)	5	UniProt NCBI
HMGB2	High mobility group protein B2 (High mobility group protein 2) (HMG-2)	5	UniProt NCBI
CALD1	Caldesmon (CDM)	5	UniProt NCBI
API5	Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL)	5	UniProt NCBI
CHMP6	Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20)	5	UniProt NCBI
EIF4B	Eukaryotic translation initiation factor 4B (eIF-4B)	5	UniProt NCBI
FAM50A	Protein FAM50A (Protein HXC-26) (Protein XAP-5)	5	UniProt NCBI
CHMP2B	Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2)	5	UniProt NCBI
LRRC47	Leucine-rich repeat-containing protein 47	4	UniProt NCBI
RTF2	Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1)	5	UniProt NCBI
HMGB1	High mobility group protein B1 (High mobility group protein 1) (HMG-1)	5	UniProt NCBI
MAP4	Microtubule-associated protein 4 (MAP-4)	5	UniProt NCBI
FAM50B	Protein FAM50B (Protein XAP-5-like)	5	UniProt NCBI
HMGB3	High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)	5	UniProt NCBI
SNF8	Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22)	5	UniProt NCBI
EDF1	Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:280	0.000153131458895	0.125	HMGB2 HMGB1	HMGB1-HMGB2-HSC70-ERP60-GAPDH complex
REAC:R-HSA-5620971	0.000550080420295	0.1875	CHMP6 HMGB1 CHMP2B	Pyroptosis
REAC:R-HSA-917729	0.00125517419044	0.1875	CHMP6 SNF8 CHMP2B	Endosomal Sorting Complex Required For Transport (ESCRT)
CORUM:1186	0.00228672316852	0.125	CHMP6 CHMP2B	ESCRT-III complex
GO:0043388	0.0024568727441	0.25	HMGB2 EDF1 GTF2B HMGB1	positive regulation of DNA binding
REAC:R-HSA-5218859	0.00713191639651	0.1875	CHMP6 HMGB1 CHMP2B	Regulated Necrosis
GO:0008301	0.00883419058623	0.1875	HMGB2 HMGB1 HMGB3	DNA binding, bending
REAC:R-HSA-5357801	0.0141363635802	0.25	HMGB2 CHMP2B HMGB1 CHMP6	Programmed Cell Death
HPA:0570772	0.017496559506	0.3125	HMGB2 HMGB1 FAM50A GTF2B CALD1	testis; peritubular cells[>=Medium]
REAC:R-HSA-9679504	0.017967304716	0.125	CHMP6 CHMP2B	Translation of Replicase and Assembly of the Replication Transcription Complex
REAC:R-HSA-9694676	0.021546998337	0.125	CHMP6 CHMP2B	Translation of Replicase and Assembly of the Replication Transcription Complex
KEGG:04217	0.024476367271	0.1875	CHMP6 HMGB1 CHMP2B	Necroptosis
REAC:R-HSA-140342	0.0254483747841	0.125	HMGB2 HMGB1	Apoptosis induced DNA fragmentation
GO:0000400	0.0362620408935	0.1875	HMGB2 HMGB1 HMGB3	four-way junction DNA binding
HPA:0460203	0.0419040356452	0.25	HMGB2 MAP4 CALD1 HMGB1	skin 1; endothelial cells[High]
GO:0051101	0.0420434160199	0.25	HMGB2 EDF1 GTF2B HMGB1	regulation of DNA binding
HPA:0470203	0.0429852733709	0.25	HMGB2 MAP4 CALD1 HMGB1	skin 2; endothelial cells[High]
REAC:R-HSA-9610379	0.0463069054035	0.1875	CHMP6 SNF8 CHMP2B	HCMV Late Events
HPA:0471493	0.0489729701894	0.1875	HMGB2 CALD1 HMGB1	skin 2; vascular mural cells[High]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
MAP4	CALD1	0.985
HMGB1	HMGB2	0.972	0.722
CALD1	CHMP2B	0.964
API5	CALD1	0.962
FAM50A	EDF1	0.954	0.14
GTF2B	EIF4B	0.95	0.094
GTF2B	CHMP6	0.948	0.074
FAM50A	CHMP6	0.946	0.036
FAM50A	GTF2B	0.944	0.04
CHMP6	LRRC47	0.94	0.072
CHMP6	CHMP2B	0.929	0.054
GTF2B	LRRC47	0.927	0.154
CALD1	HMGB3	0.927
GTF2B	CHMP2B	0.926	0.062
HMGB3	FAM50A	0.922	0.126
HMGB3	LRRC47	0.921	0.1
FAM50A	FAM50B	0.919
RTF2	FAM50A	0.916	0.076
CALD1	FAM50A	0.913
CALD1	CHMP6	0.903
HMGB1	HMGB3	0.9	0.33
CALD1	HMGB1	0.898
CALD1	LRRC47	0.892
RTF2	HMGB3	0.886	0.074
MAP4	LRRC47	0.881
HMGB2	LRRC47	0.879	0.222
HMGB2	HMGB3	0.866	0.37
API5	FAM50A	0.856	0.268
API5	LRRC47	0.855	0.222
CALD1	RTF2	0.844
CALD1	EIF4B	0.843
CALD1	EDF1	0.834
CALD1	HMGB2	0.83
CHMP2B	LRRC47	0.822	0.078
API5	HMGB3	0.819	0.11
HMGB3	CHMP2B	0.815	0.024
SNF8	CHMP6	0.811	0.058	structurally_consistent (Q9BRG1)
RTF2	LRRC47	0.783	0.028
HMGB3	GTF2B	0.775	0.028
MAP4	EIF4B	0.772
HMGB1	FAM50A	0.752	0.132
RTF2	GTF2B	0.746	0.08
RTF2	CHMP6	0.744	0.034
FAM50A	LRRC47	0.715	0.176
HMGB1	LRRC47	0.708	0.228
MAP4	CHMP2B	0.676
EIF4B	LRRC47	0.666	0.172
FAM50A	EIF4B	0.639	0.268
EDF1	LRRC47	0.637	0.212
FAM50A	CHMP2B	0.616	0.028
MAP4	GTF2B	0.607
HMGB3	EDF1	0.564	0.09
CALD1	GTF2B	0.547
CHMP2B	EIF4B	0.523	0.07
EDF1	GTF2B	0.506	0.112
API5	HMGB2	0.493	0.326
MAP4	HMGB3	0.482
HMGB3	CHMP6	0.479	0.01
API5	EIF4B	0.462	0.334
RTF2	EDF1	0.427	0.06
HMGB1	CHMP2B	0.335	0.054
EDF1	EIF4B	0.314	0.19
MAP4	FAM50A	0.298
HMGB2	EIF4B	0.281	0.242
HMGB1	GTF2B	0.258	0.106
MAP4	HMGB2	0.235
RTF2	EIF4B	0.234	0.278
API5	CHMP6	0.233	0.056
API5	MAP4	0.23
MAP4	EDF1	0.209
RTF2	HMGB1	0.201	0.06
API5	GTF2B	0.192	0.274
HMGB2	FAM50A	0.188	0.094
CHMP6	EIF4B	0.174	0.028
EDF1	CHMP6	0.166	0.046
HMGB2	EDF1	0.157	0.146
API5	EDF1	0.155	0.22
HMGB3	EIF4B	0.145	0.068
MAP4	HMGB1	0.136
MAP4	RTF2	0.128
API5	RTF2	0.124	0.136
RTF2	CHMP2B	0.121	0.046
EDF1	CHMP2B	0.108	0.032
HMGB2	GTF2B	0.097	0.036
RTF2	HMGB2	0.082	0.024
API5	HMGB1	0.081	0.39
API5	CHMP2B	0.072	0.06
HMGB1	SNF8	0.056	0.092
HMGB2	SNF8	0.054	0.07
HMGB1	EIF4B	0.04	0.204
HMGB2	CHMP6	0.038	0.016
FAM50A	SNF8	0.032	0.06
HMGB1	EDF1	0.027	0.07
RTF2	SNF8	0.024	0.022
MAP4	CHMP6	0.02
HMGB1	CHMP6	0.02	0.034
SNF8	CHMP2B	0.015	0.098
EDF1	SNF8	0.015	0.076
MAP4	SNF8	0.014
HMGB2	CHMP2B	0.01	0.062
HMGB3	SNF8	0.009	0.026
LRRC47	FAM50B	0.008
API5	SNF8	0.006	0.092

Related Complexes

Genename	Complexes
GTF2B	huMAP3_03818.1 huMAP3_11429.1 huMAP3_12523.1
HMGB2	huMAP3_00806.1 huMAP3_08690.1 huMAP3_10093.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_14618.1
CALD1	huMAP3_00227.1 huMAP3_02119.1 huMAP3_03762.1 huMAP3_06395.1 huMAP3_10673.1 huMAP3_11074.1 huMAP3_11653.1 huMAP3_12523.1
API5	huMAP3_00227.1 huMAP3_02119.1 huMAP3_03762.1 huMAP3_06395.1 huMAP3_10673.1 huMAP3_11074.1 huMAP3_11293.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_13283.1 huMAP3_14618.1 huMAP3_14750.1 huMAP3_14982.1
CHMP6	huMAP3_03988.1 huMAP3_06564.1 huMAP3_08679.1 huMAP3_10053.1 huMAP3_12523.1 huMAP3_12909.1
EIF4B	huMAP3_11429.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_14832.1
FAM50A	huMAP3_01587.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_13283.1 huMAP3_14750.1
CHMP2B	huMAP3_03988.1 huMAP3_06564.1 huMAP3_08679.1 huMAP3_10053.1 huMAP3_12523.1 huMAP3_13805.1
LRRC47	huMAP3_11653.1 huMAP3_12523.1 huMAP3_13283.1 huMAP3_14618.1 huMAP3_14982.1
RTF2	huMAP3_00559.1 huMAP3_02973.1 huMAP3_08171.1 huMAP3_10737.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_13283.1
HMGB1	huMAP3_00806.1 huMAP3_06127.1 huMAP3_08690.1 huMAP3_10049.1 huMAP3_11653.1 huMAP3_12437.1 huMAP3_12523.1 huMAP3_14618.1
MAP4	huMAP3_00227.1 huMAP3_02119.1 huMAP3_03762.1 huMAP3_06395.1 huMAP3_10673.1 huMAP3_11074.1 huMAP3_11653.1 huMAP3_11859.1 huMAP3_12523.1
FAM50B	huMAP3_11653.1 huMAP3_12523.1 huMAP3_13283.1 huMAP3_14750.1
HMGB3	huMAP3_01252.1 huMAP3_05512.1 huMAP3_08901.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_13283.1 huMAP3_14618.1 huMAP3_14750.1
SNF8	huMAP3_03029.1 huMAP3_12523.1 huMAP3_12909.1
EDF1	huMAP3_01587.1 huMAP3_11653.1 huMAP3_12523.1 huMAP3_13283.1 huMAP3_14750.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12523.1

Complex Portal: CPX-10688