hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12538.1
Complex Portal: CPX-14568
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) | 5 | UniProt NCBI |
| GORAB | RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (hNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) | 5 | UniProt NCBI |
| PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) | 5 | UniProt NCBI |
| TC2N | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | 3 | UniProt NCBI |
| CADPS | Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-429947 | 0.00418294558639 | 0.4 | PAN2 PAN3 | Deadenylation of mRNA |
| GO:0031251 | 0.00468200720083 | 0.4 | PAN2 PAN3 | PAN complex |
| KEGG:03018 | 0.0118302702264 | 0.4 | PAN2 PAN3 | RNA degradation |
| REAC:R-HSA-429914 | 0.0224106525753 | 0.4 | PAN2 PAN3 | Deadenylation-dependent mRNA decay |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PAN2 | PAN3 | 0.996 | 0.19 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| CADPS | PAN2 | 0.969 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | ||
| CADPS | TC2N | 0.939 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CADPS | PAN3 | 0.938 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GORAB | CADPS | 0.897 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GORAB | PAN2 | 0.113 | 0.074 | bioplex3_WMM WMM_only | |
| GORAB | TC2N | 0.113 | bioplex3_WMM WMM_only | ||
| GORAB | PAN3 | 0.078 | 0.148 | bioplex3_WMM WMM_only | |
| PAN3 | TC2N | 0.076 | bioplex3_WMM WMM_only | ||
| PAN2 | TC2N | 0.076 | bioplex3_WMM WMM_only |
Related Complexes