hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12543.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| R3HDML | Peptidase inhibitor R3HDML (Cysteine-rich secretory protein R3HDML) | 3 | UniProt NCBI |
| EIF5A2 | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | 5 | UniProt NCBI |
| TFAP2B | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | 5 | UniProt NCBI |
| EIF5A | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | 5 | UniProt NCBI |
| CPB1 | Carboxypeptidase B (EC 3.4.17.2) (Pancreas-specific protein) (PASP) | 5 | UniProt NCBI |
| MCFD2 | Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein) | 5 | UniProt NCBI |
| DOHH | Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1) | 5 | UniProt NCBI |
| OR10H3 | Olfactory receptor 10H3 (Olfactory receptor OR19-24) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204626 | 5.21474531955e-08 | 0.428571428571 | DOHH EIF5A2 EIF5A | Hypusine synthesis from eIF5A-lysine |
| REAC:R-HSA-163841 | 0.000100611892471 | 0.428571428571 | DOHH EIF5A2 EIF5A | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
| REAC:R-HSA-597592 | 0.0148745508598 | 0.714285714286 | DOHH EIF5A MCFD2 EIF5A2 TFAP2B | Post-translational protein modification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DOHH | EIF5A2 | 0.999 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| CPB1 | EIF5A2 | 0.998 | 0.12 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| DOHH | EIF5A | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| EIF5A2 | EIF5A | 0.994 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| EIF5A2 | TFAP2B | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MCFD2 | EIF5A2 | 0.96 | 0.118 | bioplex3_WMM bioplex3_HCT116 fraction |
| MCFD2 | R3HDML | 0.933 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MCFD2 | CPB1 | 0.89 | bioplex3_WMM WMM_only | |
| DOHH | CPB1 | 0.888 | bioplex3_WMM WMM_only | |
| DOHH | OR10H3 | 0.833 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MCFD2 | DOHH | 0.617 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only |
| MCFD2 | OR10H3 | 0.386 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CPB1 | TFAP2B | 0.214 | bioplex3_WMM WMM_only | |
| DOHH | TFAP2B | 0.175 | bioplex3_WMM WMM_only | |
| MCFD2 | TFAP2B | 0.123 | bioplex3_WMM WMM_only | |
| CPB1 | EIF5A | 0.116 | bioplex3_WMM youn_WMM WMM_only | |
| TFAP2B | EIF5A | 0.076 | bioplex3_WMM WMM_only | |
| MCFD2 | EIF5A | 0.027 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes