hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12584.1
Complex Portal: CPX-11486
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LAT | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | 5 | UniProt NCBI |
| ZDHHC6 | Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Stearoyltransferase ZDHHC6) (EC 2.3.1.-) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376) | 5 | UniProt NCBI |
| C11orf54 | Ester hydrolase C11orf54 (EC 3.1.-.-) | 5 | UniProt NCBI |
| CLDN17 | Claudin-17 | 5 | UniProt NCBI |
| ECSCR | Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2) | 5 | UniProt NCBI |
| BTC | Probetacellulin [Cleaved into: Betacellulin (BTC)] | 5 | UniProt NCBI |
| ZDHHC20 | Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20) | 5 | UniProt NCBI |
| TIGIT | T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2909 | 0.0499436884912 | 0.125 | LAT | PLC-gamma-2-Syk-LAT-FcR-gamma complex |
| CORUM:2913 | 0.0499436884912 | 0.125 | LAT | PLC-gamma-2-LAT complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZDHHC20 | LAT | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LAT | ZDHHC6 | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TIGIT | ZDHHC6 | 0.99 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZDHHC6 | CLDN17 | 0.915 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ZDHHC20 | BTC | 0.908 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZDHHC6 | BTC | 0.894 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZDHHC6 | C11orf54 | 0.85 | 0.042 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ECSCR | ZDHHC6 | 0.815 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZDHHC20 | ZDHHC6 | 0.806 | 0.09 | bioplex3_WMM WMM_only |
Related Complexes