hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12587.1

Complex Portal: CPX-23163

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
NCKAP5L	Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169)	5	UniProt NCBI
EXOC6B	Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2)	5	UniProt NCBI
EXOC1	Exocyst complex component 1 (Exocyst complex component Sec3)	5	UniProt NCBI
EXOC2	Exocyst complex component 2 (Exocyst complex component Sec5)	5	UniProt NCBI
KRT81	Keratin, type II cuticular Hb1 (Hair keratin K2.9) (Keratin, hair, basic, 1) (Keratin-81) (K81) (Metastatic lymph node 137 gene protein) (MLN 137) (Type II hair keratin Hb1) (Type-II keratin Kb21) (ghHKb1) (ghHb1)	5	UniProt NCBI
EXOC8	Exocyst complex component 8 (Exocyst complex 84 kDa subunit)	5	UniProt NCBI
KRT86	Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26)	5	UniProt NCBI
EXOC7	Exocyst complex component 7 (Exocyst complex component Exo70)	5	UniProt NCBI
PRR30	Proline-rich protein 30	2	UniProt NCBI
EXOC4	Exocyst complex component 4 (Exocyst complex component Sec8)	5	UniProt NCBI
EXOC5	Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10)	5	UniProt NCBI
IL1R2	Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]	5	UniProt NCBI
EXOC3	Exocyst complex component 3 (Exocyst complex component Sec6)	5	UniProt NCBI
EXOC6	Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0090522	1.19695467301e-24	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	vesicle tethering involved in exocytosis
CORUM:6167	3.04173919776e-24	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Exocyst complex
CORUM:89	3.04173919776e-24	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Exocyst Sec6/8 complex
GO:0000145	2.39261367713e-21	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	exocyst
REAC:R-HSA-5620916	7.13737548133e-19	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	VxPx cargo-targeting to cilium
REAC:R-HSA-264876	3.31549254493e-18	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Insulin processing
GO:0099022	1.70144877329e-17	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	vesicle tethering
GO:0006904	8.38390420531e-17	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	vesicle docking involved in exocytosis
GO:0090148	4.15226982335e-16	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	membrane fission
REAC:R-HSA-5620920	4.21272429116e-15	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Cargo trafficking to the periciliary membrane
GO:0140029	6.27756078076e-15	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	exocytic process
GO:0048278	6.27756078076e-15	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	vesicle docking
GO:0006903	1.06100396301e-14	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	vesicle targeting
GO:0099023	2.04268606983e-14	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	vesicle tethering complex
GO:0140056	5.79215026432e-14	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	organelle localization by membrane tethering
REAC:R-HSA-2980736	9.20525474484e-14	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Peptide hormone metabolism
REAC:R-HSA-1445148	1.33862248669e-13	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Translocation of SLC2A4 (GLUT4) to the plasma membrane
GO:0022406	1.89083980459e-13	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	membrane docking
GO:0000281	2.71555011884e-13	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	mitotic cytokinesis
WP:WP5366	8.72138702645e-13	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	NF1 copy number variation syndrome
GO:0061640	2.66386587579e-12	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	cytoskeleton-dependent cytokinesis
WP:WP4352	4.61751902384e-12	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	Ciliary landscape
GO:0000910	1.53258371698e-10	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	cytokinesis
GO:0051650	2.69182516083e-10	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	establishment of vesicle localization
GO:0005938	3.71291864808e-10	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	cell cortex
GO:0051648	3.71291864808e-10	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	vesicle localization
REAC:R-HSA-5617833	5.32326865112e-10	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Cilium Assembly
GO:0006893	1.05591548829e-09	0.5	EXOC8 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2	Golgi to plasma membrane transport
GO:0006887	3.8769233812e-09	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	exocytosis
GO:0051301	5.98248728146e-09	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	cell division
REAC:R-HSA-1852241	1.08620442123e-08	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Organelle biogenesis and maintenance
CORUM:6169	3.65216022462e-08	0.214285714286	EXOC5 EXOC7 EXOC6	Exocyst EXOC5-EXOC6-EXOC7 subcomplex
GO:0006892	6.47560191011e-08	0.5	EXOC8 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2	post-Golgi vesicle-mediated transport
GO:0051656	3.22815261067e-07	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	establishment of organelle localization
GO:0098876	5.77386949909e-07	0.5	EXOC8 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2	vesicle-mediated transport to the plasma membrane
GO:0032940	2.58811372001e-06	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	secretion by cell
GO:0051640	2.90350223112e-06	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	organelle localization
REAC:R-HSA-199991	3.6424182251e-06	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Membrane Trafficking
REAC:R-HSA-5653656	5.57287786546e-06	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Vesicle-mediated transport
GO:0046903	5.92049978751e-06	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	secretion
GO:0140352	6.1314447449e-06	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	export from cell
GO:0061024	1.5250578788e-05	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	membrane organization
GO:1903047	2.52425123855e-05	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	mitotic cell cycle process
CORUM:6168	4.44741811353e-05	0.142857142857	EXOC5 EXOC6	Exocyst EXOC5-EXOC6 subcomplex
GO:0048193	0.000104423733982	0.5	EXOC8 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2	Golgi vesicle transport
GO:0000278	0.000135278907507	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	mitotic cell cycle
HPA:0230301	0.0012547589864	0.142857142857	KRT81 KRT86	hair; cells in cortex/medulla[>=Low]
HPA:0230302	0.0012547589864	0.142857142857	KRT81 KRT86	hair; cells in cortex/medulla[>=Medium]
HPA:0230303	0.0012547589864	0.142857142857	KRT81 KRT86	hair; cells in cortex/medulla[High]
GO:0022402	0.0019477802701	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	cell cycle process
KEGG:05132	0.00265095563083	0.285714285714	EXOC5 EXOC4 EXOC2 EXOC7	Salmonella infection
HP:0007468	0.00271806002538	0.142857142857	KRT81 KRT86	Perifollicular hyperkeratosis
GO:0016192	0.00523406773447	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	vesicle-mediated transport
WP:WP2290	0.0065190163061	0.142857142857	EXOC2 EXOC8	RalA downstream regulated genes
HP:0031285	0.00905028290189	0.142857142857	KRT81 KRT86	Abnormal perifollicular morphology
GO:0051668	0.0110446825518	0.5	EXOC8 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2	localization within membrane
HPA:0230000	0.0113621772057	0.142857142857	KRT81 KRT86	hair
REAC:R-HSA-392499	0.0150601315098	0.571428571429	EXOC7 EXOC2 EXOC5 EXOC3 EXOC4 EXOC6 EXOC1 EXOC8	Metabolism of proteins
GO:0007049	0.0167270623364	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	cell cycle
GO:0051649	0.0392088332041	0.642857142857	EXOC7 EXOC3 EXOC1 EXOC5 EXOC6B EXOC4 EXOC6 EXOC2 EXOC8	establishment of localization in cell

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
EXOC6B	EXOC8	1.0	0.46
EXOC7	EXOC8	1.0	0.878	structurally_consistent (dimer)
EXOC8	EXOC6	1.0	0.218	structurally_consistent (Q9UPT5)
EXOC7	EXOC6	1.0	0.102	structurally_consistent (dimer)
EXOC1	EXOC3	1.0	0.82	mutually_exclusive (Q96KP1)
EXOC5	EXOC6	1.0	0.214
EXOC8	EXOC5	1.0	0.736	structurally_consistent (Q96A65) structurally_consistent (dimer)
EXOC2	EXOC3	1.0	0.956	structurally_consistent (dimer)
EXOC4	EXOC3	1.0	0.45
EXOC6B	EXOC5	1.0	0.268	structurally_consistent (dimer)
EXOC1	EXOC2	1.0	0.834	structurally_consistent (dimer)
EXOC7	EXOC3	1.0	0.486
EXOC1	EXOC4	1.0	0.73
EXOC3	EXOC6	1.0	0.154
EXOC5	EXOC3	1.0	0.608
EXOC6B	EXOC7	1.0	0.48
EXOC1	EXOC6	1.0	0.176
EXOC2	EXOC8	1.0	0.512
EXOC1	EXOC8	1.0	0.606
EXOC4	EXOC6	1.0	0.178
EXOC6B	EXOC3	1.0	0.392
EXOC2	EXOC6	1.0	0.09
EXOC8	EXOC4	0.999	0.374	structurally_consistent (dimer)
EXOC1	EXOC7	0.999	0.57
EXOC1	EXOC5	0.999	0.782
EXOC6B	EXOC4	0.999	0.254
EXOC7	EXOC5	0.999	0.802
IL1R2	EXOC6B	0.999		structurally_consistent (O00471)
IL1R2	EXOC8	0.999		structurally_consistent (O00471)
EXOC6B	EXOC2	0.999	0.362
IL1R2	EXOC6	0.999
EXOC8	EXOC3	0.999	0.786
IL1R2	EXOC7	0.998
EXOC6B	EXOC6	0.998	0.016
IL1R2	EXOC1	0.998
IL1R2	EXOC5	0.998		structurally_consistent (dimer)
EXOC6B	EXOC1	0.998	0.374
EXOC2	EXOC5	0.998	0.788
EXOC2	EXOC4	0.998	0.818
IL1R2	EXOC2	0.997
EXOC7	EXOC4	0.997	0.232
IL1R2	EXOC4	0.996
EXOC2	EXOC7	0.996	0.4
IL1R2	EXOC3	0.995
EXOC4	EXOC5	0.991	0.474	structurally_consistent (dimer)
IL1R2	PRR30	0.986
KRT86	EXOC4	0.973	0.056
NCKAP5L	EXOC1	0.951	0.104
EXOC4	KRT81	0.922
EXOC3	KRT81	0.761
KRT86	KRT81	0.697
NCKAP5L	EXOC6	0.237	0.056
NCKAP5L	EXOC2	0.22	0.11
NCKAP5L	EXOC5	0.209	0.106
NCKAP5L	EXOC3	0.185	0.104
NCKAP5L	EXOC6B	0.164	0.062
NCKAP5L	EXOC7	0.155	0.086
NCKAP5L	EXOC8	0.05	0.064
NCKAP5L	EXOC4	0.044	0.11
EXOC1	KRT86	0.027	0.054
NCKAP5L	KRT81	0.022
EXOC2	KRT86	0.009	0.024
KRT86	EXOC5	0.009	0.044
KRT86	EXOC3	0.009	0.012
EXOC8	KRT86	0.009	0.024
EXOC7	KRT86	0.009	0.02
EXOC2	KRT81	0.009
EXOC6B	KRT81	0.009
EXOC7	KRT81	0.009
EXOC1	KRT81	0.009
EXOC6B	KRT86	0.009	0.016
KRT86	EXOC6	0.009	0.05
EXOC6	KRT81	0.009
EXOC5	KRT81	0.009
EXOC8	KRT81	0.008

Related Complexes

Genename	Complexes
NCKAP5L	huMAP3_03150.1 huMAP3_05389.1 huMAP3_06331.1 huMAP3_11306.1 huMAP3_11911.1 huMAP3_12062.1 huMAP3_12337.1 huMAP3_12587.1 huMAP3_13393.1
EXOC6B	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
EXOC1	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
EXOC2	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
KRT81	huMAP3_12587.1 huMAP3_14032.1
EXOC8	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
KRT86	huMAP3_04054.1 huMAP3_06887.1 huMAP3_09839.1 huMAP3_12587.1 huMAP3_14032.1
EXOC7	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
PRR30	huMAP3_01624.1 huMAP3_02199.1 huMAP3_07009.1 huMAP3_07634.1 huMAP3_08254.1 huMAP3_09839.1 huMAP3_12587.1 huMAP3_13679.1
EXOC4	huMAP3_04054.1 huMAP3_06887.1 huMAP3_09839.1 huMAP3_12587.1 huMAP3_14032.1
EXOC5	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1
IL1R2	huMAP3_01624.1 huMAP3_02199.1 huMAP3_07009.1 huMAP3_07634.1 huMAP3_08254.1 huMAP3_09839.1 huMAP3_12587.1 huMAP3_13679.1
EXOC3	huMAP3_04054.1 huMAP3_04817.1 huMAP3_07009.1 huMAP3_09487.1 huMAP3_09839.1 huMAP3_12587.1
EXOC6	huMAP3_04054.1 huMAP3_07009.1 huMAP3_09839.1 huMAP3_12587.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12587.1

Complex Portal: CPX-23163