hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12594.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OBSCN | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | 5 | UniProt NCBI |
| NPPA | Natriuretic peptides A (Atrial natriuretic factor prohormone) (proANF) (Atrial natriuretic peptide prohormone) (preproANP) (proANP) (Atriopeptigen) (Cardiodilatin) (CDD) (preproCDD-ANF) [Cleaved into: Long-acting natriuretic peptide (LANP) (Long-acting natriuretic hormone) (LANH) (Pro atrial natriuretic factor 1-30) (proANF 1-30) (Pro atrial natriuretic peptide 1-30) (proANP 1-30); Vessel dilator (VSDL) (Pro atrial natriuretic factor 31-67) (proANF 31-67) (Pro atrial natriuretic peptide 31-67) (proANP 31-67); Kaliuretic peptide (KP) (Pro atrial natriuretic factor 79-98) (proANF 79-98) (Pro atrial natriuretic peptide 79-98) (proANP 79-98); Urodilatin (URO) (CDD 95-126) (CDD-ANP (95-126)) (Pro atrial natriuretic peptide 95-126) (proANP 95-126); Auriculin-C (Atrial natriuretic factor 1-33) (ANF 1-33); Auriculin-D (Atrial natriuretic factor 3-33) (ANF 3-33); Atrial natriuretic peptide (ANP) (Alpha-atrial natriuretic peptide) (Alpha-hANP) (Atrial natriuretic factor) (ANF) (CDD-ANF) (CDD-ANP (99-126)) (Cardionatrin) (Pro atrial natriuretic factor 99-126) (proANF 99-126); Auriculin-B (Atrial natriuretic factor 8-33) (ANF 8-33); Auriculin-A; Atriopeptin-1 (Atriopeptin I); Atriopeptin-2 (Atriopeptin II); Atriopeptin-3 (Atriopeptin III)] | 5 | UniProt NCBI |
| NME2 | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | 5 | UniProt NCBI |
| NME4 | Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4) | 5 | UniProt NCBI |
| NME1 | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00240 | 0.00247340401034 | 0.5 | NME2 NME4 | Pyrimidine metabolism |
| REAC:R-HSA-499943 | 0.00258893271292 | 0.5 | NME2 NME4 | Interconversion of nucleotide di- and triphosphates |
| KEGG:00983 | 0.00551283411821 | 0.5 | NME2 NME4 | Drug metabolism - other enzymes |
| KEGG:01232 | 0.00601982850302 | 0.5 | NME2 NME4 | Nucleotide metabolism |
| KEGG:00230 | 0.0118173906169 | 0.5 | NME2 NME4 | Purine metabolism |
| KEGG:01240 | 0.0220824431074 | 0.5 | NME2 NME4 | Biosynthesis of cofactors |
| REAC:R-HSA-15869 | 0.0297941212351 | 0.5 | NME2 NME4 | Metabolism of nucleotides |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NME2 | NME1 | 0.996 | 0.94 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only |
| OBSCN | NPPA | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NME1 | NME4 | 0.982 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NPPA | NME1 | 0.955 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NPPA | NME2 | 0.921 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NME2 | NME4 | 0.914 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| OBSCN | NME1 | 0.007 | 0.104 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| OBSCN | NME2 | 0.005 | 0.062 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 boldt_WMM |
Related Complexes