hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12595.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF34 | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | 5 | UniProt NCBI |
| TTC23 | Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) | 5 | UniProt NCBI |
| RFFL | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | 5 | UniProt NCBI |
| TTC23L | Tetratricopeptide repeat protein 23-like | 5 | UniProt NCBI |
| IQCE | IQ domain-containing protein E | 5 | UniProt NCBI |
| SHC1 | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | 5 | UniProt NCBI |
| EFCAB7 | EF-hand calcium-binding domain-containing protein 7 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4536 | 0.000413392056955 | 0.5 | TTC23 EFCAB7 IQCE | Genes related to primary cilium development based on CRISPR |
| REAC:R-HSA-5635838 | 0.00200991204249 | 0.333333333333 | IQCE EFCAB7 | Activation of SMO |
| KEGG:04340 | 0.0071411999113 | 0.333333333333 | IQCE EFCAB7 | Hedgehog signaling pathway |
| REAC:R-HSA-6804757 | 0.0152705482636 | 0.333333333333 | RNF34 RFFL | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 0.0161658624528 | 0.333333333333 | RNF34 RFFL | Regulation of TP53 Expression and Degradation |
| GO:2001271 | 0.0210651876021 | 0.333333333333 | RNF34 RFFL | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF34 | RFFL | 0.999 | 0.158 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| TTC23L | IQCE | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RFFL | IQCE | 0.999 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| EFCAB7 | TTC23L | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RFFL | SHC1 | 0.998 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| TTC23 | IQCE | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EFCAB7 | TTC23 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EFCAB7 | IQCE | 0.972 | bioplex_WMM bioplex3_WMM WMM_only | |
| RNF34 | SHC1 | 0.894 | bioplex_WMM bioplex3_WMM WMM_only | |
| RNF34 | IQCE | 0.878 | bioplex_WMM bioplex3_WMM WMM_only | |
| SHC1 | IQCE | 0.855 | bioplex_WMM bioplex3_WMM WMM_only | |
| EFCAB7 | RFFL | 0.78 | bioplex3_HEK293 bioplex () bioplex3_WMM | |
| RNF34 | EFCAB7 | 0.708 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EFCAB7 | SHC1 | 0.101 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes