hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12615.1
Complex Portal: CPX-25383
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZBTB10 | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | 5 | UniProt NCBI |
| WTIP | Wilms tumor protein 1-interacting protein (WT1-interacting protein) | 5 | UniProt NCBI |
| EFL1 | Elongation factor-like GTPase 1 (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A) | 5 | UniProt NCBI |
| SLFN12 | Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12) | 5 | UniProt NCBI |
| ZNF576 | Zinc finger protein 576 | 4 | UniProt NCBI |
| PDLIM7 | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | 5 | UniProt NCBI |
| PTPN21 | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | 5 | UniProt NCBI |
| ZBTB40 | Zinc finger and BTB domain-containing protein 40 | 4 | UniProt NCBI |
| TRIP6 | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | 5 | UniProt NCBI |
| AJUBA | LIM domain-containing protein ajuba | 5 | UniProt NCBI |
| LIMD1 | LIM domain-containing protein 1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 4.1638833312e-05 | 0.272727272727 | LIMD1 WTIP AJUBA | Hippo signaling pathway - multiple species |
| REAC:R-HSA-1234176 | 0.00318376318131 | 0.272727272727 | LIMD1 WTIP AJUBA | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| GO:0035331 | 0.00347628273893 | 0.272727272727 | LIMD1 WTIP AJUBA | negative regulation of hippo signaling |
| GO:0060148 | 0.00347628273893 | 0.272727272727 | LIMD1 WTIP AJUBA | positive regulation of post-transcriptional gene silencing |
| GO:1900370 | 0.00347628273893 | 0.272727272727 | LIMD1 WTIP AJUBA | positive regulation of post-transcriptional gene silencing by RNA |
| GO:2000637 | 0.00347628273893 | 0.272727272727 | LIMD1 WTIP AJUBA | positive regulation of miRNA-mediated gene silencing |
| REAC:R-HSA-1234174 | 0.00437606749304 | 0.272727272727 | LIMD1 WTIP AJUBA | Cellular response to hypoxia |
| KEGG:04390 | 0.00774471138932 | 0.272727272727 | LIMD1 WTIP AJUBA | Hippo signaling pathway |
| GO:0035278 | 0.0107228250299 | 0.272727272727 | LIMD1 WTIP AJUBA | miRNA-mediated gene silencing by inhibition of translation |
| GO:0060147 | 0.0152674746611 | 0.272727272727 | LIMD1 WTIP AJUBA | regulation of post-transcriptional gene silencing |
| GO:0060964 | 0.0152674746611 | 0.272727272727 | LIMD1 WTIP AJUBA | regulation of miRNA-mediated gene silencing |
| GO:1900368 | 0.0152674746611 | 0.272727272727 | LIMD1 WTIP AJUBA | regulation of post-transcriptional gene silencing by regulatory ncRNA |
| GO:0060966 | 0.0209381437171 | 0.272727272727 | LIMD1 WTIP AJUBA | regulation of gene silencing by regulatory ncRNA |
| GO:0035330 | 0.0318245054916 | 0.272727272727 | LIMD1 WTIP AJUBA | regulation of hippo signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AJUBA | TRIP6 | 0.999 | 0.096 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTIP | TRIP6 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| AJUBA | PTPN21 | 0.997 | 0.116 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EFL1 | TRIP6 | 0.996 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PDLIM7 | TRIP6 | 0.996 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| AJUBA | LIMD1 | 0.994 | 0.068 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PDLIM7 | ZNF576 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| AJUBA | ZNF576 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TRIP6 | LIMD1 | 0.987 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| SLFN12 | PDLIM7 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TRIP6 | ZNF576 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| ZNF576 | ZBTB40 | 0.965 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| EFL1 | WTIP | 0.965 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AJUBA | PDLIM7 | 0.962 | 0.07 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| AJUBA | WTIP | 0.936 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF576 | LIMD1 | 0.934 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| AJUBA | EFL1 | 0.932 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF576 | ZBTB10 | 0.927 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PDLIM7 | ZBTB10 | 0.9 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| PDLIM7 | LIMD1 | 0.665 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| PTPN21 | TRIP6 | 0.664 | 0.182 | bioplex_WMM bioplex3_WMM WMM_only | |
| PTPN21 | LIMD1 | 0.631 | 0.046 | bioplex3_WMM WMM_only | |
| TRIP6 | ZBTB10 | 0.236 | 0.06 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| AJUBA | ZBTB10 | 0.225 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| WTIP | PDLIM7 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZBTB40 | ZBTB10 | 0.194 | 0.096 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| WTIP | LIMD1 | 0.188 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PTPN21 | ZBTB10 | 0.187 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLFN12 | TRIP6 | 0.165 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AJUBA | ZBTB40 | 0.164 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| EFL1 | PDLIM7 | 0.155 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLFN12 | ZBTB10 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SLFN12 | LIMD1 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZBTB10 | LIMD1 | 0.142 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EFL1 | LIMD1 | 0.105 | 0.028 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TRIP6 | ZBTB40 | 0.058 | 0.05 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ZBTB40 | LIMD1 | 0.053 | 0.086 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PDLIM7 | ZBTB40 | 0.051 | 0.11 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PTPN21 | PDLIM7 | 0.026 | 0.09 | bioplex3_WMM WMM_only |
Related Complexes