hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12616.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPGRIP1L | Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) | 5 | UniProt NCBI |
| TRAIP | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) | 5 | UniProt NCBI |
| NPHP1 | Nephrocystin-1 (Juvenile nephronophthisis 1 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5399 | 5.0954861614e-05 | 0.666666666667 | NPHP1 RPGRIP1L | NPHP1 deletion syndrome |
| HP:0000276 | 0.00173315691363 | 1.0 | NPHP1 RPGRIP1L TRAIP | Long face |
| HP:0032599 | 0.00193466002352 | 0.666666666667 | NPHP1 RPGRIP1L | Abnormal renal tubular epithelial morphology |
| HP:0000092 | 0.00193466002352 | 0.666666666667 | NPHP1 RPGRIP1L | Renal tubular atrophy |
| HP:0100729 | 0.00230958793402 | 1.0 | NPHP1 RPGRIP1L TRAIP | Large face |
| WP:WP4656 | 0.00280600716639 | 0.666666666667 | NPHP1 RPGRIP1L | Joubert syndrome |
| HP:0002536 | 0.00572267550502 | 1.0 | NPHP1 RPGRIP1L TRAIP | Abnormal cortical gyration |
| HP:0000090 | 0.00708857159683 | 0.666666666667 | NPHP1 RPGRIP1L | Nephronophthisis |
| HP:0002419 | 0.00708857159683 | 0.666666666667 | NPHP1 RPGRIP1L | Molar tooth sign on MRI |
| HP:0002612 | 0.00936084070842 | 0.666666666667 | NPHP1 RPGRIP1L | Congenital hepatic fibrosis |
| HP:0001883 | 0.0095874285512 | 1.0 | NPHP1 RPGRIP1L TRAIP | Talipes |
| HP:0005656 | 0.00987431656569 | 1.0 | NPHP1 RPGRIP1L TRAIP | Positional foot deformity |
| HP:0002269 | 0.0106164498774 | 1.0 | NPHP1 RPGRIP1L TRAIP | Abnormality of neuronal migration |
| HP:0004207 | 0.0117165861789 | 1.0 | NPHP1 RPGRIP1L TRAIP | Abnormal 5th finger morphology |
| WP:WP4803 | 0.0135986549013 | 0.666666666667 | NPHP1 RPGRIP1L | Ciliopathies |
| HP:0100957 | 0.0180650213362 | 0.666666666667 | NPHP1 RPGRIP1L | Abnormal renal medulla morphology |
| HP:0032581 | 0.0180650213362 | 0.666666666667 | NPHP1 RPGRIP1L | Abnormal renal insterstitial morphology |
| HP:0004422 | 0.0201452261528 | 0.666666666667 | NPHP1 RPGRIP1L | Biparietal narrowing |
| REAC:R-HSA-5620912 | 0.0290482612381 | 0.666666666667 | NPHP1 RPGRIP1L | Anchoring of the basal body to the plasma membrane |
| HP:0002418 | 0.0295957156854 | 0.666666666667 | NPHP1 RPGRIP1L | Abnormal midbrain morphology |
| HP:0010579 | 0.0304647837379 | 0.666666666667 | NPHP1 TRAIP | Cone-shaped epiphysis |
| HP:0011314 | 0.0383682142819 | 1.0 | NPHP1 RPGRIP1L TRAIP | Abnormal long bone morphology |
| HP:0000112 | 0.0418708017344 | 0.666666666667 | NPHP1 RPGRIP1L | Nephropathy |
| HP:0000091 | 0.0429026841472 | 0.666666666667 | NPHP1 RPGRIP1L | Abnormal renal tubule morphology |
| HP:0002538 | 0.0478252330498 | 1.0 | NPHP1 RPGRIP1L TRAIP | Abnormal cerebral cortex morphology |
| CORUM:6750 | 0.0499402709677 | 0.333333333333 | NPHP1 | AHI1-NPHP1 heterotetramer |
| CORUM:6743 | 0.0499402709677 | 0.333333333333 | NPHP1 | AHI1-NPHP1 heterodimer |
| CORUM:6600 | 0.0499402709677 | 0.333333333333 | NPHP1 | NPHP1-PKD1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPGRIP1L | NPHP1 | 0.993 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta () boldt gupta_WMM boldt_WMM | |
| TRAIP | NPHP1 | 0.983 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RPGRIP1L | TRAIP | 0.25 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RPGRIP1L | huMAP3_04884.1 huMAP3_12616.1 huMAP3_14472.1 huMAP3_15176.1 |
| TRAIP | huMAP3_04884.1 huMAP3_12616.1 huMAP3_14073.1 huMAP3_14472.1 huMAP3_15176.1 |
| NPHP1 | huMAP3_04884.1 huMAP3_12616.1 huMAP3_14073.1 huMAP3_14472.1 huMAP3_15176.1 |